scholarly journals Exophilin-5 regulates allergic airway inflammation by controlling IL-33–mediated Th2 responses

2020 ◽  
Vol 130 (7) ◽  
pp. 3919-3935 ◽  
Author(s):  
Katsuhide Okunishi ◽  
Hao Wang ◽  
Maho Suzukawa ◽  
Ray Ishizaki ◽  
Eri Kobayashi ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Responses

scholarly journals Protective effects of combined Mycobacterium bovis BCG and interleukin-12 vaccination on airway inflammation in a murine model of allergic asthma

2010 ◽  
Vol 33 (3) ◽  
pp. 196 ◽  
Author(s):  
Xia Ke ◽  
Jiangju Huang ◽  
Quan Chen ◽  
Suling Hong ◽  
Daoyin Zhu
Keyword(s):  
Airway Inflammation ◽  
Allergic Asthma ◽  
Mycobacterium Bovis ◽  
Immunoglobulin E ◽  
Allergic Airway Inflammation ◽  
Interleukin 12 ◽  
Protective Effects ◽  
Th2 Response ◽  
Bcg Vaccination ◽  
Th2 Responses

Purpose. Allergic asthma is characterized by chronic airway inflammation and airway hyperresponsiveness driven by allergen-specific T helper (Th)2 cells. Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccination has been documented to suppress Th2 responses and allergic airway inflammation in animal models. Since interleukin (IL)-12 is capable of inhibiting Th2 responses, we sought to investigate whether IL-12 could function as an adjuvant to increase the efficacy of BCG vaccination against allergic asthma. Methods. BALB/c neonatal mice (24 mice, 48-72 h old) were randomly divided into 3 subgroups (n = 8 for each group) to be immunized with PBS (control) or BCG with or without DNA plasmid-expressing IL-12. All of the mice were then sensitized and provoked with ovalbumin (OVA) to establish a model of allergic asthma. Results. Mice vaccinated with BCG alone showed a significant reduction in airway inflammation, percentage of eosinophils in bronchoalveolar lavage (BAL) fluid, and serum OVA-specific immunoglobulin E (IgE) levels in comparison with control animals. The suppressive effects of BCG were substantially augmented by the combination with IL-12. Furthermore, a decreased IL-4 and increased interferon-gamma (IFN-γ) production in BAL fluid were observed in animals inoculated with BCG alone or with IL-12 relative to control animals. Conclusion. Our data indicate that the combined vaccination with BCG and IL-12 yields a favorable outcome in prevention of experimental allergic airway inflammation, which is likely mediated through triggering a shift from a Th2 response to a Th1 response.

scholarly journals T Cell-Derived Act1 Is Necessary for IL-25–Mediated Th2 Responses and Allergic Airway Inflammation

2011 ◽  
Vol 187 (6) ◽  
pp. 3155-3164 ◽  
Author(s):  
Shadi Swaidani ◽  
Katarzyna Bulek ◽  
Zizhen Kang ◽  
Muhammet Fatih Gulen ◽  
Caini Liu ◽  
...  
Keyword(s):  
T Cell ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Responses

scholarly journals Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization

2016 ◽  
Vol 113 (18) ◽  
pp. 5059-5064 ◽  
Author(s):  
Charles B. Smarr ◽  
Woon Teck Yap ◽  
Tobias P. Neef ◽  
Ryan M. Pearson ◽  
Zoe N. Hunter ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Significant Risk ◽  
Allergic Airway Inflammation ◽  
Allergic Diseases ◽  
Soluble Antigen ◽  
Ag Nps ◽  
Th2 Responses ◽  
Allergy Treatment ◽  
Biodegradable Poly ◽  
Induction Of Tolerance

Specific immunotherapy (SIT) is the most widely used treatment for allergic diseases that directly targets the T helper 2 (Th2) bias underlying allergy. However, the most widespread clinical applications of SIT require a long period of dose escalation with soluble antigen (Ag) and carry a significant risk of adverse reactions, particularly in highly sensitized patients who stand to benefit most from a curative treatment. Thus, the development of safer, more efficient methods to induce Ag-specific immune tolerance is critical to advancing allergy treatment. We hypothesized that antigen-associated nanoparticles (Ag-NPs), which we have used to prevent and treat Th1/Th17-mediated autoimmune disease, would also be effective for the induction of tolerance in a murine model of Th2-mediated ovalbumin/alum-induced allergic airway inflammation. We demonstrate here that antigen-conjugated polystyrene (Ag-PS) NPs, although effective for the prophylactic induction of tolerance, induce anaphylaxis in presensitized mice. Antigen-conjugated NPs made of biodegradable poly(lactide-co-glycolide) (Ag-PLG) are similarly effective prophylactically, are well tolerated by sensitized animals, but only partially inhibit Th2 responses when administered therapeutically. PLG NPs containing encapsulated antigen [PLG(Ag)], however, were well tolerated and effectively inhibited Th2 responses and airway inflammation both prophylactically and therapeutically. Thus, we illustrate progression toward PLG(Ag) as a biodegradable Ag carrier platform for the safe and effective inhibition of allergic airway inflammation without the need for nonspecific immunosuppression in animals with established Th2 sensitization.

Lipopolysaccharide inhalation exacerbates allergic airway inflammation by activating mast cells and promoting Th2 responses

2007 ◽  
Vol 37 (3) ◽  
pp. 339-347 ◽  
Author(s):  
D. Murakami ◽  
H. Yamada ◽  
T. Yajima ◽  
A. Masuda ◽  
S. Komune ◽  
...  
Keyword(s):  
Mast Cells ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Responses

scholarly journals B7RP-1 Is Not Required for the Generation of Th2 Responses in a Model of Allergic Airway Inflammation but Is Essential for the Induction of Inhalation Tolerance

2005 ◽  
Vol 174 (5) ◽  
pp. 3000-3005 ◽  
Author(s):  
Beata U. Gajewska ◽  
Anna Tafuri ◽  
Filip K. Świrski ◽  
Tina Walker ◽  
Jill R. Johnson ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Responses

Attenuated allergic airway inflammation in Cd39-/- mice

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
M Idzko ◽  
K Ayata ◽  
T Müller ◽  
T Dürk ◽  
M Grimm ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation
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