scholarly journals T Cell-Derived Act1 Is Necessary for IL-25–Mediated Th2 Responses and Allergic Airway Inflammation

2011 ◽  
Vol 187 (6) ◽  
pp. 3155-3164 ◽  
Author(s):  
Shadi Swaidani ◽  
Katarzyna Bulek ◽  
Zizhen Kang ◽  
Muhammet Fatih Gulen ◽  
Caini Liu ◽  
...  
Keyword(s):  
T Cell ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Responses

scholarly journals Androgen Receptor Signaling Augments Regulatory T Cell Functions to Attenuate Allergic Airway Inflammation

2021 ◽  
Vol 147 (2) ◽  
pp. AB3
Author(s):  
Vivek Gandhi ◽  
Jacqueline Cephus ◽  
Nowrin Chowdhury ◽  
Allison Norlander ◽  
Stokes Peebles ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
T Cell ◽  
Airway Inflammation ◽  
Regulatory T Cell ◽  
Allergic Airway Inflammation ◽  
Receptor Signaling ◽  
Androgen Receptor Signaling ◽  
Cell Functions

USP4 is pathogenic in allergic airway inflammation by inhibiting regulatory T cell response

Life Sciences ◽  
2021 ◽  
pp. 119720
Author(s):  
Xiaoxia Hou ◽  
Fangming Zhu ◽  
Yingmeng Ni ◽  
Tiantian Chen ◽  
Juan Du ◽  
...  
Keyword(s):  
T Cell ◽  
Airway Inflammation ◽  
Regulatory T Cell ◽  
Cell Response ◽  
Allergic Airway Inflammation ◽  
T Cell Response

scholarly journals Protective effects of combined Mycobacterium bovis BCG and interleukin-12 vaccination on airway inflammation in a murine model of allergic asthma

2010 ◽  
Vol 33 (3) ◽  
pp. 196 ◽  
Author(s):  
Xia Ke ◽  
Jiangju Huang ◽  
Quan Chen ◽  
Suling Hong ◽  
Daoyin Zhu
Keyword(s):  
Airway Inflammation ◽  
Allergic Asthma ◽  
Mycobacterium Bovis ◽  
Immunoglobulin E ◽  
Allergic Airway Inflammation ◽  
Interleukin 12 ◽  
Protective Effects ◽  
Th2 Response ◽  
Bcg Vaccination ◽  
Th2 Responses

Purpose. Allergic asthma is characterized by chronic airway inflammation and airway hyperresponsiveness driven by allergen-specific T helper (Th)2 cells. Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccination has been documented to suppress Th2 responses and allergic airway inflammation in animal models. Since interleukin (IL)-12 is capable of inhibiting Th2 responses, we sought to investigate whether IL-12 could function as an adjuvant to increase the efficacy of BCG vaccination against allergic asthma. Methods. BALB/c neonatal mice (24 mice, 48-72 h old) were randomly divided into 3 subgroups (n = 8 for each group) to be immunized with PBS (control) or BCG with or without DNA plasmid-expressing IL-12. All of the mice were then sensitized and provoked with ovalbumin (OVA) to establish a model of allergic asthma. Results. Mice vaccinated with BCG alone showed a significant reduction in airway inflammation, percentage of eosinophils in bronchoalveolar lavage (BAL) fluid, and serum OVA-specific immunoglobulin E (IgE) levels in comparison with control animals. The suppressive effects of BCG were substantially augmented by the combination with IL-12. Furthermore, a decreased IL-4 and increased interferon-gamma (IFN-γ) production in BAL fluid were observed in animals inoculated with BCG alone or with IL-12 relative to control animals. Conclusion. Our data indicate that the combined vaccination with BCG and IL-12 yields a favorable outcome in prevention of experimental allergic airway inflammation, which is likely mediated through triggering a shift from a Th2 response to a Th1 response.

Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats

2009 ◽  
Vol 22 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Muhammad Shahzad ◽  
Xudong Yang ◽  
M.B. Raza Asim ◽  
Qingzhu Sun ◽  
Yan Han ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Airway Inflammation ◽  
Seed Oil ◽  
Allergic Airway Inflammation ◽  
T Cell Proliferation ◽  
Black Seed ◽  
Black Seed Oil

NKT cells and CD8+ T cells are dispensable for T cell dependent allergic airway inflammation

2007 ◽  
Author(s):  
Jyoti Das ◽  
Paul Eynott ◽  
Luc Van Kaer ◽  
Yufang Shi ◽  
Gobardhan Das
Keyword(s):  
T Cells ◽  
T Cell ◽  
Airway Inflammation ◽  
Cd8 T Cells ◽  
Allergic Airway Inflammation ◽  
Nkt Cells

scholarly journals Overlapping and Distinct Roles of STAT4 and T-bet in the Regulation of T Cell Differentiation and Allergic Airway Inflammation

2008 ◽  
Vol 180 (10) ◽  
pp. 6656-6662 ◽  
Author(s):  
Shunsuke Furuta ◽  
Shin-ichiro Kagami ◽  
Tomohiro Tamachi ◽  
Kei Ikeda ◽  
Michio Fujiwara ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
T Cell Differentiation
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