scholarly journals Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

2019 ◽  
Vol 130 (1) ◽  
pp. 480-490 ◽  
Author(s):  
Alice E. Wiedeman ◽  
Virginia S. Muir ◽  
Mario G. Rosasco ◽  
Hannah A. DeBerg ◽  
Scott Presnell ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Slow Type ◽  
Diabetes Progression

scholarly journals Harnessing CD8 + T‐cell exhaustion to treat type 1 diabetes

2021 ◽  
Author(s):  
Chun‐Ting J Kwong ◽  
Claudia Selck ◽  
Krisna Tahija ◽  
Lachlan J McAnaney ◽  
Dan V Le ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion

scholarly journals Type 1 diabetes progression is associated with loss of CD3+CD56+ regulatory T cells that control CD8+ T-cell effector functions

2020 ◽  
Vol 2 (2) ◽  
pp. 142-152 ◽  
Author(s):  
Giuseppe Terrazzano ◽  
Sara Bruzzaniti ◽  
Valentina Rubino ◽  
Marianna Santopaolo ◽  
Anna Teresa Palatucci ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cells ◽  
Cd8 T Cell ◽  
Effector Functions ◽  
Diabetes Progression ◽  
Cell Effector

In vivo imaging of a diabetogenic CD8+ T cell response during type 1 diabetes progression

2008 ◽  
Vol 59 (4) ◽  
pp. 712-720 ◽  
Author(s):  
Zdravka Medarova ◽  
Sue Tsai ◽  
Natalia Evgenov ◽  
Pere Santamaria ◽  
Anna Moore
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Cell Response ◽  
In Vivo Imaging ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Diabetes Progression

scholarly journals The Potential of T Cell Factor 1 in Sustaining CD8+ T Lymphocyte-Directed Anti-Tumor Immunity

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 515
Author(s):  
Sungmin Jung ◽  
Jea-Hyun Baek
Keyword(s):  
T Cell ◽  
Tumor Immunity ◽  
T Lymphocyte ◽  
Critical Role ◽  
Cd8 T Cell ◽  
Immune Checkpoint Blockade ◽  
Viral Escape ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
T Cell Factor

T cell factor 1 (TCF1) is a transcription factor that has been highlighted to play a critical role in the promotion of T cell proliferation and maintenance of cell stemness in the embryonic and CD8+ T cell populations. The regulatory nature of TCF1 in CD8+ T cells is of great significance, especially within the context of T cell exhaustion, which is linked to the tumor and viral escape in pathological contexts. Indeed, inhibitory signals, such as programmed cell death 1 (PD-1) and cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4), expressed on exhausted T lymphocytes (TEX), have become major therapeutic targets in immune checkpoint blockade (ICB) therapy. The significance of TCF1 in the sustenance of CTL-mediated immunity against pathogens and tumors, as well as its recently observed necessity for an effective anti-tumor immune response in ICB therapy, presents TCF1 as a potentially significant biomarker and/or therapeutic target for overcoming CD8+ T cell exhaustion and resistance to ICB therapy. In this review, we aim to outline the recent findings on the role of TCF1 in T cell development and discuss its implications in anti-tumor immunity.

scholarly journals Peripheral autoreactive CD8 T‐cell frequencies are too variable to be a reliable predictor of disease progression of human type 1 diabetes

2021 ◽  
Vol 10 (7) ◽  
Author(s):  
Johnna D Wesley ◽  
Susanne Pfeiffer ◽  
Darius Schneider ◽  
David Friedrich ◽  
Nikole Perdue ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Disease Progression ◽  
Cd8 T Cell ◽  
Human Type ◽  
Reliable Predictor ◽  
Human Type 1 Diabetes

scholarly journals CD5 expressing CD8 + T cell subsets differ between children with Type 1 diabetes and controls

2021 ◽  
Author(s):  
Josefine Wadenpohl ◽  
Julia Seyfarth ◽  
Paul Hehenkamp ◽  
Maximilian Hoffmann ◽  
Sebastian Kummer ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Subsets
Sign in / Sign up

Export Citation Format

Share Document