In vivo imaging of a diabetogenic CD8+ T cell response during type 1 diabetes progression

2008 ◽  
Vol 59 (4) ◽  
pp. 712-720 ◽  
Author(s):  
Zdravka Medarova ◽  
Sue Tsai ◽  
Natalia Evgenov ◽  
Pere Santamaria ◽  
Anna Moore
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Cell Response ◽  
In Vivo Imaging ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Diabetes Progression

scholarly journals A Switch in Costimulation from CD28 to 4-1BB during Primary versus Secondary CD8 T Cell Response to Influenza In Vivo

2004 ◽  
Vol 172 (2) ◽  
pp. 981-988 ◽  
Author(s):  
Edward M. Bertram ◽  
Wojciech Dawicki ◽  
Bradley Sedgmen ◽  
Jonathan L. Bramson ◽  
David H. Lynch ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response

scholarly journals A non-functional neoepitope specific CD8+ T-cell response induced by tumor derived antigen exposure in vivo

2018 ◽  
Vol 8 (3) ◽  
pp. 1553478 ◽  
Author(s):  
Mathias Vormehr ◽  
Katharina Reinhard ◽  
Renata Blatnik ◽  
Kathrin Josef ◽  
Jan David Beck ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Exposure In Vivo

scholarly journals Type 1 diabetes progression is associated with loss of CD3+CD56+ regulatory T cells that control CD8+ T-cell effector functions

2020 ◽  
Vol 2 (2) ◽  
pp. 142-152 ◽  
Author(s):  
Giuseppe Terrazzano ◽  
Sara Bruzzaniti ◽  
Valentina Rubino ◽  
Marianna Santopaolo ◽  
Anna Teresa Palatucci ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cells ◽  
Cd8 T Cell ◽  
Effector Functions ◽  
Diabetes Progression ◽  
Cell Effector

scholarly journals Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection

2004 ◽  
Vol 78 (13) ◽  
pp. 7069-7078 ◽  
Author(s):  
Todd M. Allen ◽  
Marcus Altfeld ◽  
Xu G. Yu ◽  
Kristin M. O'Sullivan ◽  
Mathias Lichterfeld ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Antigen Processing ◽  
Cytotoxic T Lymphocyte ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T-lymphocyte epitopes. Here we combine sequence data and functional studies of CD8 T-cell responses to demonstrate that allele-specific immune pressures also select for mutations flanking CD8 epitopes that impair antigen processing. In persons expressing HLA-A3, we demonstrate consistent selection for a mutation in a C-terminal flanking residue of the normally immunodominant Gag KK9 epitope that prevents its processing and presentation, resulting in a rapid decline in the CD8 T-cell response. This single amino acid substitution also lies within a second HLA-A3-restricted epitope, with the mutation directly impairing recognition by CD8 T cells. Transmission of the mutation to subjects expressing HLA-A3 was shown to prevent the induction of normally immunodominant acute-phase responses to both epitopes. However, subsequent in vivo reversion of the mutation was coincident with delayed induction of new CD8 T-cell responses to both epitopes. These data demonstrate that mutations within the flanking region of an HIV-1 epitope can impair recognition by an established CD8 T-cell response and that transmission of these mutations alters the acute-phase CD8+ T-cell response. Moreover, reversion of these mutations in the absence of the original immune pressure reveals the potential plasticity of immunologically selected evolutionary changes.

scholarly journals Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

2019 ◽  
Vol 130 (1) ◽  
pp. 480-490 ◽  
Author(s):  
Alice E. Wiedeman ◽  
Virginia S. Muir ◽  
Mario G. Rosasco ◽  
Hannah A. DeBerg ◽  
Scott Presnell ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Slow Type ◽  
Diabetes Progression

Modulation of the Autoimmune T Cell Response in Type 1 Diabetes by Self β-cell microRNA

2010 ◽  
Vol 135 ◽  
pp. S124
Author(s):  
Apolline Salama ◽  
Nolwenn Fichou ◽  
Marie Allard ◽  
Steffi Bosch, Jean-Marie Bach
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Β Cell

scholarly journals Induction of CD4+CD25+Foxp3+ regulatory T cell response by glatiramer acetate in type 1 diabetes

Cell Research ◽  
2009 ◽  
Vol 19 (5) ◽  
pp. 574-583 ◽  
Author(s):  
Guoliang Cui ◽  
Yuebo Zhang ◽  
Zhenwei Gong ◽  
Jingwu Z Zhang ◽  
Ying Qin Zang
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Glatiramer Acetate ◽  
Regulatory T Cell ◽  
Cell Response ◽  
T Cell Response

Letter to the Editor: CD8 T Cell Response to Nef Peptides and HIV Type 1 Control in Early-Treated Patients after Antiretroviral Treatment Interruption

2006 ◽  
Vol 22 (4) ◽  
pp. 330-332 ◽  
Author(s):  
Fabrizio Poccia ◽  
Cristiana Gioia ◽  
Angela Corpolongo ◽  
Gianpiero D'Offizi ◽  
Pasquale Narcisco ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Antiretroviral Treatment ◽  
Treatment Interruption ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Letter To The Editor ◽  
Hiv Type 1

scholarly journals Conditioning of Langerhans Cells Induced by a Primary CD8 T Cell Response to Self-Antigen In Vivo

2006 ◽  
Vol 176 (8) ◽  
pp. 4658-4665 ◽  
Author(s):  
Dita Mayerova ◽  
Liangchun Wang ◽  
Laura S. Bursch ◽  
Kristin A. Hogquist
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Langerhans Cells ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Self Antigen
Sign in / Sign up

Export Citation Format

Share Document