scholarly journals Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats.

1996 ◽  
Vol 97 (1) ◽  
pp. 238-243 ◽  
Author(s):  
J L Wautier ◽  
C Zoukourian ◽  
O Chappey ◽  
M P Wautier ◽  
P J Guillausseau ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Advanced Glycation End Products ◽  
Diabetic Rats ◽  
Endothelial Cell Dysfunction ◽  
Soluble Receptor ◽  
Advanced Glycation ◽  
Cell Dysfunction ◽  
Diabetic Vasculopathy ◽  
Glycation End Products ◽  
End Products

Advanced glycation end products of human β2 glycoprotein I modulate the maturation and function of DCs

Blood ◽  
2011 ◽  
Vol 117 (23) ◽  
pp. 6152-6161 ◽  
Author(s):  
Brigitta Buttari ◽  
Elisabetta Profumo ◽  
Antonella Capozzi ◽  
Francesco Facchiano ◽  
Luciano Saso ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Advanced Glycation End Products ◽  
Target Antigen ◽  
Endothelial Cell Dysfunction ◽  
Advanced Glycation ◽  
Cell Dysfunction ◽  
Glycoprotein I ◽  
Glycation End Products ◽  
End Products ◽  
Chronic Disorders

Abstract In chronic disorders related to endothelial cell dysfunction, plasma β2 glycoprotein I (β2GPI) plays a role as a target antigen of pathogenetic autoimmune responses. However, information is still lacking to clarify why β2GPI triggers autoimmunity. It is possible that posttranslational modification of the protein, such as nonenzymatic glycosylation, leads to the formation of advanced glycation end products (AGEs). The aim of our study was to explore whether glucose-modified β2GPI is able to interact and activate monocyte-derived immature dendritic cells (iDCs) from healthy human donors. SDS-PAGE and spectrofluorometric analyses indicated that β2GPI incubated with glucose was sugar modified, and that this modification likely consisted of AGE formation, resulting in AGE-β2GPI. AGE-β2GPI caused phenotypical and functional maturation of iDCs involving the activation of p38 MAPK, ERK, and NF-κB. It also induced on DCs a significant up-regulation of RAGE, the receptor for AGEs. Evidence for RAGE involvement comes from blocking experiments with an anti-RAGE mAb, confocal analysis, and coimmunoprecipitation experiments. AGE-β2GPI–stimulated DCs had increased allostimulatory ability and primed naive T lymphocytes toward a Th2 polarization. These findings might explain in part the interactive role of β2GPI, AGEs, and DCs in chronic disorders related to endothelial cell dysfunction.

Association of Soluble Receptor for Advanced Glycation End Products Levels with Hypertensive Albuminuria

2015 ◽  
Vol 13 (2) ◽  
pp. 259-264
Author(s):  
Huan Zheng ◽  
Lingyan Yuan ◽  
Nanzi Xie ◽  
Huifeng Xu ◽  
Xiaoyun Xie ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Soluble Receptor ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products
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