scholarly journals Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate.

1995 ◽  
Vol 96 (6) ◽  
pp. 2966-2974 ◽  
Author(s):  
C P Genain ◽  
M H Nguyen ◽  
N L Letvin ◽  
R Pearl ◽  
R L Davis ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nonhuman Primate

scholarly journals The spectrum of spinal cord lesions in a primate model of multiple sclerosis

2019 ◽  
Vol 26 (3) ◽  
pp. 284-293 ◽  
Author(s):  
Jennifer A Lefeuvre ◽  
Joseph R Guy ◽  
Nicholas J Luciano ◽  
Seung-Kwon Ha ◽  
Emily Leibovitch ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Nonhuman Primate ◽  
Ex Vivo ◽  
Inflammatory Cells ◽  
Common Marmoset ◽  
Autoimmune Encephalomyelitis ◽  
Primate Model ◽  
Magnetic Resonance Imaging Mri ◽  
Experimental Autoimmune

Background: Experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a nonhuman primate model of multiple sclerosis (MS) that shares numerous clinical, radiological, and pathological features with MS. Among the clinical features are motor and sensory deficits that are highly suggestive of spinal cord (SC) damage. Objective: To characterize the extent and nature of SC damage in symptomatic marmosets with EAE using a combined magnetic resonance imaging (MRI) and histopathology approach. Materials and Methods: SC tissues from five animals were scanned using 7 T MRI to collect high-resolution ex vivo images. Lesions were segmented and classified based on shape, size, and distribution along the SC. Tissues were processed for histopathological characterization (myelin and microglia/macrophages). Statistical analysis, using linear mixed-effects models, evaluated the association between MRI and histopathology. Results: Marmosets with EAE displayed two types of SC lesions: focal and subpial lesions. Both lesion types were heterogeneous in size and configuration and corresponded to areas of marked demyelination with high density of inflammatory cells. Inside the lesions, the MRI signal was significantly correlated with myelin content ( p < 0.001). Conclusions: Our findings underscore the relevance of this nonhuman primate EAE model for better understanding mechanisms of MS lesion formation in the SC.

scholarly journals Herpesvirus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis

2018 ◽  
Vol 115 (44) ◽  
pp. 11292-11297 ◽  
Author(s):  
Emily C. Leibovitch ◽  
Breanna Caruso ◽  
Seung Kwon Ha ◽  
Matthew K. Schindler ◽  
Nathanael J. Lee ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nonhuman Primate ◽  
Viral Antigen ◽  
Disease Onset ◽  
Brain Lesions ◽  
Autoimmune Encephalomyelitis ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Neuroinflammatory Disease ◽  
Human Herpesviruses

Pathogens, particularly human herpesviruses (HHVs), are implicated as triggers of disease onset/progression in multiple sclerosis (MS) and other neuroinflammatory disorders. However, the time between viral acquisition in childhood and disease onset in adulthood complicates the study of this association. Using nonhuman primates, we demonstrate that intranasal inoculations with HHV-6A and HHV-6B accelerate an MS-like neuroinflammatory disease, experimental autoimmune encephalomyelitis (EAE). Although animals inoculated intranasally with HHV-6 (virus/EAE marmosets) were asymptomatic, they exhibited significantly accelerated clinical EAE compared with control animals. Expansion of a proinflammatory CD8 subset correlated with post-EAE survival in virus/EAE marmosets, suggesting that a peripheral (viral?) antigen-driven expansion may have occurred post-EAE induction. HHV-6 viral antigen in virus/EAE marmosets was markedly elevated and concentrated in brain lesions, similar to previously reported localizations of HHV-6 in MS brain lesions. Collectively, we demonstrate that asymptomatic intranasal viral acquisition accelerates subsequent neuroinflammation in a nonhuman primate model of MS.

scholarly journals Japanese macaque encephalomyelitis: A spontaneous multiple sclerosis-like disease in a nonhuman primate

2011 ◽  
Vol 70 (3) ◽  
pp. 362-373 ◽  
Author(s):  
Michael K. Axthelm ◽  
Dennis N. Bourdette ◽  
Gail H. Marracci ◽  
Weiping Su ◽  
Elizabeth T. Mullaney ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nonhuman Primate ◽  
Japanese Macaque

scholarly journals Suppression of Ongoing Disease in a Nonhuman Primate Model of Multiple Sclerosis by a Human-Anti-Human IL-12p40 Antibody

2005 ◽  
Vol 175 (7) ◽  
pp. 4761-4768 ◽  
Author(s):  
Bert A. ’t Hart ◽  
Herbert P. M. Brok ◽  
Ed Remarque ◽  
Jacqueline Benson ◽  
George Treacy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model

Electron Microscopic Detection and Characterization of Nonhuman Primate Enteric Viruses

1982 ◽  
Vol 40 ◽  
pp. 306-307
Author(s):  
G. C. Smith ◽  
R. L. Heberling ◽  
S. S. Kalter
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Nonhuman Primate ◽  
Clinical Condition ◽  
Intestinal Tract ◽  
Enteric Viruses ◽  
Electron Microscopic ◽  
Microscopic Detection

A number of viral agents are recognized as and suspected of causing the clinical condition “gastroenteritis.” In our attempts to establish an animal model for studies of this entity, we have been examining the nonhuman primate to ascertain what viruses may be found in the intestinal tract of “normal” animals as well as animals with diarrhea. Several virus types including coronavirus, adenovirus, herpesvirus, and picornavirus (Table I) were detected in our colony; however, rotavirus, astrovirus, and calicivirus have not yet been observed. Fecal specimens were prepared for electron microscopy by procedures reported previously.

Microglia-derived macrophages in early multiple sclerosis plaques

1996 ◽  
Vol 22 (3) ◽  
pp. 207-215 ◽  
Author(s):  
H. Li ◽  
M. L. Cuzner ◽  
J. Newcombe
Keyword(s):  
Multiple Sclerosis
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