Preclinical Assessment of Therapeutic Antibodies against Human CD40 and Human Interleukin-12/23p40 in a Nonhuman Primate Model of Multiple Sclerosis

2007 ◽  
Vol 5 (1) ◽  
pp. 38-52 ◽  
Author(s):  
Bert A. ’t Hart ◽  
Rogier Q. Hintzen ◽  
Jon D. Laman
Keyword(s):  
Multiple Sclerosis ◽  
Nonhuman Primate ◽  
Interleukin 12 ◽  
Therapeutic Antibodies ◽  
Nonhuman Primate Model ◽  
Primate Model

scholarly journals Herpesvirus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis

2018 ◽  
Vol 115 (44) ◽  
pp. 11292-11297 ◽  
Author(s):  
Emily C. Leibovitch ◽  
Breanna Caruso ◽  
Seung Kwon Ha ◽  
Matthew K. Schindler ◽  
Nathanael J. Lee ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nonhuman Primate ◽  
Viral Antigen ◽  
Disease Onset ◽  
Brain Lesions ◽  
Autoimmune Encephalomyelitis ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Neuroinflammatory Disease ◽  
Human Herpesviruses

Pathogens, particularly human herpesviruses (HHVs), are implicated as triggers of disease onset/progression in multiple sclerosis (MS) and other neuroinflammatory disorders. However, the time between viral acquisition in childhood and disease onset in adulthood complicates the study of this association. Using nonhuman primates, we demonstrate that intranasal inoculations with HHV-6A and HHV-6B accelerate an MS-like neuroinflammatory disease, experimental autoimmune encephalomyelitis (EAE). Although animals inoculated intranasally with HHV-6 (virus/EAE marmosets) were asymptomatic, they exhibited significantly accelerated clinical EAE compared with control animals. Expansion of a proinflammatory CD8 subset correlated with post-EAE survival in virus/EAE marmosets, suggesting that a peripheral (viral?) antigen-driven expansion may have occurred post-EAE induction. HHV-6 viral antigen in virus/EAE marmosets was markedly elevated and concentrated in brain lesions, similar to previously reported localizations of HHV-6 in MS brain lesions. Collectively, we demonstrate that asymptomatic intranasal viral acquisition accelerates subsequent neuroinflammation in a nonhuman primate model of MS.

scholarly journals Suppression of Ongoing Disease in a Nonhuman Primate Model of Multiple Sclerosis by a Human-Anti-Human IL-12p40 Antibody

2005 ◽  
Vol 175 (7) ◽  
pp. 4761-4768 ◽  
Author(s):  
Bert A. ’t Hart ◽  
Herbert P. M. Brok ◽  
Ed Remarque ◽  
Jacqueline Benson ◽  
George Treacy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model

Maternal High-Fat Diet Persistently Alters Bone Marrow Immune Cell Proportions and Function in a Nonhuman Primate Model

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 222-OR
Author(s):  
MICHAEL J. NASH ◽  
TAYLOR K. SODERBORG ◽  
RACHEL C. JANSSEN ◽  
ERIC M. PIETRAS ◽  
JACOB E. FRIEDMAN
Keyword(s):  
Bone Marrow ◽  
Nonhuman Primate ◽  
High Fat Diet ◽  
Immune Cell ◽  
High Fat ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
And Function

scholarly journals Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke

2020 ◽  
Author(s):  
Di Wu ◽  
Yongjuan Fu ◽  
Longfei Wu ◽  
Mitchell Huber ◽  
Jian Chen ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model

Robotic Assessment of Upper Limb Function in a Nonhuman Primate Model of Chronic Stroke

2021 ◽  
Author(s):  
Yining Chen ◽  
Meredith C. Poole ◽  
Shelby V. Olesovsky ◽  
Allen A. Champagne ◽  
Kathleen A. Harrison ◽  
...  
Keyword(s):  
Upper Limb ◽  
Nonhuman Primate ◽  
Chronic Stroke ◽  
Nonhuman Primate Model ◽  
Limb Function ◽  
Primate Model ◽  
Upper Limb Function

scholarly journals Transcriptomic phases of periodontitis lesions using the nonhuman primate model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeffrey L. Ebersole ◽  
Radhakrishnan Nagarajan ◽  
Sreenatha Kirakodu ◽  
Octavio A. Gonzalez
Keyword(s):  
Gene Expression ◽  
Nonhuman Primate ◽  
Gingival Crevicular Fluid ◽  
Inflammatory Responses ◽  
Expression Profiles ◽  
Lesion Detection ◽  
Gingival Tissue ◽  
Specific Gene ◽  
Nonhuman Primate Model ◽  
Primate Model

AbstractWe used a nonhuman primate model of ligature-induced periodontitis to identify patterns of gingival transcriptomic after changes demarcating phases of periodontitis lesions (initiation, progression, resolution). A total of 18 adult Macaca mulatta (12–22 years) had ligatures placed (premolar, 1st molar teeth) in all 4 quadrants. Gingival tissue samples were obtained (baseline, 2 weeks, 1 and 3 months during periodontitis and at 5 months resolution). Gene expression was analyzed by microarray [Rhesus Gene 1.0 ST Array (Affymetrix)]. Compared to baseline, a large array of genes were significantly altered at initiation (n = 6049), early progression (n = 4893), and late progression (n = 5078) of disease, with the preponderance being up-regulated. Additionally, 1918 genes were altered in expression with disease resolution, skewed towards down-regulation. Assessment of the genes demonstrated specific profiles of epithelial, bone/connective tissue, apoptosis/autophagy, metabolism, regulatory, immune, and inflammatory responses that were related to health, stages of disease, and tissues with resolved lesions. Unique transcriptomic profiles occured during the kinetics of the periodontitis lesion exacerbation and remission. We delineated phase specific gene expression profiles of the disease lesion. Detection of these gene products in gingival crevicular fluid samples from human disease may contribute to a better understanding of the biological dynamics of the disease to improve patient management.

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