scholarly journals Expression of human lecithin-cholesterol acyltransferase in transgenic mice. Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism.

1995 ◽  
Vol 96 (3) ◽  
pp. 1440-1448 ◽  
Author(s):  
O L Francone ◽  
E L Gong ◽  
D S Ng ◽  
C J Fielding ◽  
E M Rubin
Keyword(s):  
Transgenic Mice ◽  
Cholesterol Metabolism ◽  
Cholesterol Acyltransferase ◽  
Plasma Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Apolipoprotein Ai ◽  
Human Apolipoprotein ◽  
Lecithin Cholesterol Acyltransferase

Free cholesterol deposition in the cornea of human apolipoprotein A-II transgenic mice with functional lecithin: Cholesterol acyltransferase deficiency

Metabolism ◽  
1999 ◽  
Vol 48 (4) ◽  
pp. 415-421 ◽  
Author(s):  
Josep Julve-Gil ◽  
Elena Ruiz-Pérez ◽  
Ricardo P. Casaroli-Marano ◽  
Àfrica Marzal-Casacuberta ◽  
Joan Carles Escolà-Gil ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Free Cholesterol ◽  
Cholesterol Acyltransferase ◽  
Human Apolipoprotein ◽  
Lecithin Cholesterol Acyltransferase ◽  
Apolipoprotein A

Effect of Ajuga iva on enzymes involved in the metabolism of cholesterol, in rat fed a cholesterol-enriched diet

2019 ◽  
Vol 50 (2) ◽  
pp. 303-313
Author(s):  
Sherazede Bouderbala ◽  
Malika Bouchenak
Keyword(s):  
Design Methodology ◽  
Cholesterol Metabolism ◽  
Cholesterol Acyltransferase ◽  
Cholesteryl Esters ◽  
Unesterified Cholesterol ◽  
Acyltransferase Activity ◽  
Content Type ◽  
Lecithin Cholesterol Acyltransferase ◽  
Male Wistar Rats ◽  
Adaptation Phase

Purpose This study aims to investigate the effect of Ajuga iva (Ai) on enzymes involved in the metabolism of cholesterol, in rat fed a cholesterol-enriched diet. Design/methodology/approach Male Wistar rats (n = 12), weighing 120 ± 5 g were fed on 1 per cent cholesterol-enriched diet [hypercholesterolemic (HC)] for 15 days (d15). After this adaptation phase, HC rats (total cholesterol = 6.5 ± 0.6 mmol/L) were divided into two groups fed the same diet and treated (Ai-HC) or not with (HC) with Ai for d15. Findings At day 15, in Ai-HC group compared to HC, serum triacylglycerol (TG) values were 1.4-fold lower (p = 0.002), whereas unesterified cholesterol (UC) contents were 1.8-fold higher (p = 0.0001). Serum phospholipids (PL) and cholesteryl esters (CE) contents and liver TG, UC, PL and CE values were not sensitive to Ai. TC/HDL-C and LDL-HDL1-C/HDL-C ratios were, respectively, 1.8- and 4-fold lower (p = 0.006 and p = 0.04). HDL2-C and HDL3-C amounts were enhanced by 40 and 74 per cent, respectively (p = 0.003 and p = 0.0001). HDL3-UC was 1.6-fold higher (p = 0.006); whereas PL contents were 1.4-fold lower (p = 0.003). HDL3-apo and HDL2-CE contents were similar between groups. A decreased of hydroxy-methyl-glutaryl-coenzyme A reductase and cholesterol 7α-hydroxylase activities (−44 and −25 per cent; p = 0.003 and p = 0.02, respectively) were noted. Lecithin: cholesterol acyltransferase activity was 1.5-fold higher (p = 0.001). Originality/value In HC rat, Ai is able to induce hypotriglyceridemia. However, it turns out that Ai may reduce cardiovascular risk by decreasing the reports of atherogenicity and modifying the activities of enzymes involved in the cholesterol metabolism.

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