Cholesterol Efflux, Lecithin−Cholesterol Acyltransferase Activity, and Pre-β Particle Formation by Serum from Human Apolipoprotein A-I and Apolipoprotein A-I/Apolipoprotein A-II Transgenic Mice Consistent with the Latter Being Less Effective for Reverse Cholesterol Transport†

Biochemistry ◽  
1997 ◽  
Vol 36 (8) ◽  
pp. 2243-2249 ◽  
Author(s):  
Graciela Castro ◽  
Laurence Parmentier Nihoul ◽  
Catherine Dengremont ◽  
Catherine de Geitère ◽  
Bernard Delfly ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Efflux ◽  
Cholesterol Acyltransferase ◽  
Particle Formation ◽  
Cholesterol Transport ◽  
Acyltransferase Activity ◽  
Human Apolipoprotein ◽  
Lecithin Cholesterol Acyltransferase ◽  
Apolipoprotein A

Free cholesterol deposition in the cornea of human apolipoprotein A-II transgenic mice with functional lecithin: Cholesterol acyltransferase deficiency

Metabolism ◽  
1999 ◽  
Vol 48 (4) ◽  
pp. 415-421 ◽  
Author(s):  
Josep Julve-Gil ◽  
Elena Ruiz-Pérez ◽  
Ricardo P. Casaroli-Marano ◽  
Àfrica Marzal-Casacuberta ◽  
Joan Carles Escolà-Gil ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Free Cholesterol ◽  
Cholesterol Acyltransferase ◽  
Human Apolipoprotein ◽  
Lecithin Cholesterol Acyltransferase ◽  
Apolipoprotein A

scholarly journals Overexpression of Human Apolipoprotein A-II in Transgenic Mice Does Not Impair Macrophage-Specific Reverse Cholesterol Transport In Vivo

2005 ◽  
Vol 25 (9) ◽  
pp. 1896-1896 ◽  
Author(s):  
Noemí Rotllan ◽  
Vicent Ribas ◽  
Laura Calpe-Berdiel ◽  
Jesús M. Martín-Campos ◽  
Francisco Blanco-Vaca ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport ◽  
Human Apolipoprotein ◽  
Apolipoprotein A

Changes in LPLa and reverse cholesterol transport variables during 24-h postexercise period

2002 ◽  
Vol 283 (2) ◽  
pp. E267-E274 ◽  
Author(s):  
John Q. Zhang ◽  
Bryan Smith ◽  
Melissa M. Langdon ◽  
Heidi L. Messimer ◽  
Grace Y. Sun ◽  
...  
Keyword(s):  
Reverse Cholesterol Transport ◽  
Time Course ◽  
Cholesterol Acyltransferase ◽  
Density Lipoprotein ◽  
Cholesterol Transport ◽  
Protein Activity ◽  
Acyltransferase Activity ◽  
Lecithin Cholesterol Acyltransferase ◽  
Sedentary Population ◽  
Exercise Induced

We investigated the time course of exercise-induced lipoprotein lipase activity (LPLa) and reverse cholesterol transport (RCT) during the 24-h postexercise period. Subjects were 10 sedentary normolipidemic males [NTG; fasting triglyceride (TG) = 89.1 ± 8.6 mg/dl] and 6 hyperlipidemic males (HTG; fasting TG = 296.8 ± 64.0 mg/dl). Each subject performed a control trial (no exercise) and 4 exercise trials. In the exercise trials, a subject jogged on a treadmill at 60% of his maximal O2 consumption for 1 h. Pre- and postheparin blood samples were taken before exercise (baseline) and at 4, 8, 12, and 24 h after exercise. There was no group difference in LPLa ( P > 0.05) over the time points. When the LPLa data from the two groups were combined, LPLa at 24 h after exercise was higher than baseline or at 4, 8, 12 h after exercise ( P < 0.05). Plasma TG and lecithin-cholesterol acyltransferase activity (LCATa) were higher in HTG than in NTG, and the total high-density lipoprotein-cholesterol (HDLtot-Chol) was lower in HTG than in NTG ( P < 0.05). HDL2-Chol, LCATa, and cholesterol ester transfer protein activity did not differ during the 24-h postexercise period ( P > 0.05). These results suggest that LPLa is still increasing 24 h after an acute aerobic exercise and that the magnitude of the increase in exercise-induced LPLa in HTG was similar to that in NTG. Furthermore, in the sedentary population with or without HTG, the variables related to RCT do not change during the 24-h period after exercise.

scholarly journals Opposite Effects of Plasma From Human Apolipoprotein A-II Transgenic Mice on Cholesterol Efflux From J774 Macrophages and Fu5AH Hepatoma Cells

2002 ◽  
Vol 22 (4) ◽  
pp. 638-643 ◽  
Author(s):  
Natalie Fournier ◽  
Anne Cogny ◽  
Véronique Atger ◽  
Danièle Pastier ◽  
Dominique Goudouneche ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cholesterol Efflux ◽  
Hepatoma Cells ◽  
Human Apolipoprotein ◽  
Apolipoprotein A
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