scholarly journals Variable region expression in the antibody responses of infants vaccinated with Haemophilus influenzae type b polysaccharide-protein conjugates. Description of a new lambda light chain-associated idiotype and the relation between idiotype expression, avidity, and vaccine formulation. The Collaborative Vaccine Study Group.

1993 ◽  
Vol 91 (3) ◽  
pp. 788-796 ◽  
Author(s):  
D M Granoff ◽  
P G Shackelford ◽  
S J Holmes ◽  
A H Lucas
Keyword(s):  
Light Chain ◽  
Variable Region ◽  
Antibody Responses ◽  
Haemophilus Influenzae Type ◽  
Study Group ◽  
Haemophilus Influenzae Type B ◽  
Vaccine Formulation ◽  
Type B ◽  
Lambda Light Chain ◽  
Protein Conjugates

Haemophilus influenzae Type b Polysaccharide-Diphtheria Toxoid Conjugate Vaccine in Vaccinated Children Who Developed Haemophilus Disease

PEDIATRICS ◽  
1990 ◽  
Vol 86 (4) ◽  
pp. 617-620
Author(s):  
GEOFFREY A. WEINBERG ◽  
TRUDY V. MURPHY ◽  
DAN M. GRANOFF
Keyword(s):  
Haemophilus Influenzae ◽  
Normal Serum ◽  
Antibody Responses ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Healthy Children ◽  
Type B ◽  
Vaccine Failure ◽  
Polyribosylribitol Phosphate ◽  
Conventional Type

Children in whom invasive Haemophilus influenzae type b disease develops despite previous immunization with conventional type b polysaccharide vaccine (polyribosylribitol phosphate [PRP]) have been reported to have impaired serum anticapsular antibody responses following recovery from H influenzae type b disease.1,2 Recently, these "vaccine failure" patients also have been found to have impaired antibody responses to reimmunization with PRP vaccine.3 The reasons are not understood because most of the children have normal serum concentrations of immunoglobulins, including IgG2.1-4 They also are more than 3 years of age at the time of reimmunization, an age group in which most healthy children respond to PRP vaccine.

Effect of immunity to the carrier protein on antibody responses to Haemophilus influenzae type b conjugate vaccines

Vaccine ◽  
1993 ◽  
Vol 11 ◽  
pp. S46-S51 ◽  
Author(s):  
Dan M. Granoff ◽  
Mobeen H. Rathore ◽  
Sandra J. Holmes ◽  
Paul D. Granoff ◽  
Alexander H. Lucas
Keyword(s):  
Haemophilus Influenzae ◽  
Antibody Responses ◽  
Haemophilus Influenzae Type ◽  
Carrier Protein ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Conjugate Vaccines
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