scholarly journals Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity.

1991 ◽  
Vol 87 (6) ◽  
pp. 2258-2265 ◽  
Author(s):  
P E Desrochers ◽  
J J Jeffrey ◽  
S J Weiss
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 1 ◽  
Interstitial Collagenase

scholarly journals An Autocrine/Paracrine Role of Human Decidual Relaxin. I. Interstitial Collagenase (Matrix Metalloproteinase-1) and Tissue Plasminogen Activator1

1997 ◽  
Vol 56 (4) ◽  
pp. 800-811 ◽  
Author(s):  
Xuejin Qin ◽  
Jermelina Garibay-Tupas ◽  
Pong Kian Chua ◽  
Leinani Cachola ◽  
Gillian D. Bryant-Greenwood
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 1 ◽  
Tissue Plasminogen ◽  
Interstitial Collagenase

scholarly journals Expression of Interstitial Collagenase (Matrix Metalloproteinase-1) in Gastric Cancers

1997 ◽  
Vol 88 (4) ◽  
pp. 401-406 ◽  
Author(s):  
Yoshihiko Sakurai ◽  
Yoshihide Otani ◽  
Kaori Kameyama ◽  
Yasuhiro Hosoda ◽  
Isao Okazaki ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Gastric Cancers ◽  
Matrix Metalloproteinase 1 ◽  
Interstitial Collagenase

Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions

1997 ◽  
Vol 68 (2) ◽  
pp. 246-251 ◽  
Author(s):  
Isabelle Kokorine ◽  
Michelle Nisolle ◽  
Jacques Donnez ◽  
Yves Eeckhout ◽  
Pierre J. Courtoy ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 1 ◽  
Interstitial Collagenase

scholarly journals Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1)

1998 ◽  
Vol 331 (1) ◽  
pp. 341-346 ◽  
Author(s):  
Matthew P. VINCENTI ◽  
Charles I. COON ◽  
J. Andrew MENGSHOL ◽  
Sue YOCUM ◽  
Peter MITCHELL ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Time Course ◽  
Interleukin 1 ◽  
Connective Tissue Diseases ◽  
Synovial Fibroblasts ◽  
Matrix Metalloproteinase 1 ◽  
Rabbit Gene ◽  
Factor Α ◽  
Interstitial Collagenase

Cartilage, bone and the interstitial stroma, composed largely of the interstitial collagens, types I, II and III, are remodelled by three members of the metalloproteinase (MMP) family, collagenase-1 (MMP-1), collagenase-2 (MMP-8) and collagenase-3 (MMP-13). MMP-1 and MMP-13 may contribute directly to disease progression, since they are induced in patients with rheumatoid arthritis and osteoarthritis. The study of MMP-1 and MMP-13 gene regulation in models of arthritic disease has been problematic because mice and rats, which are typically used, only possess a homologue of MMP-13. Here we show that in contrast with mice and rats, rabbits possess distinct genes homologous to human MMP-1 and MMP-13. Furthermore, rabbit MMP-13 is expressed simultaneously with MMP-1 in chondrocytes and synovial fibroblasts in response to the cytokines interleukin-1 and tumour necrosis factor-α, or the phorbol ester PMA. The time course of MMP-13 induction is more rapid and transient than that of MMP-1, suggesting that distinct mechanisms regulate the expression of these two collagenases. We have cloned the rabbit MMP-13 gene from synovial fibroblasts and demonstrated that the rabbit gene shares greater homology with human MMP-13 than does the mouse interstitial collagenase. Together with the fact that mice and rats do not possess a homologue to human MMP-1, our data suggest that the rabbit provides an appropriate model for studying the roles of interstitial collagenases in connective-tissue diseases, such as rheumatoid arthritis and osteoarthritis.

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