scholarly journals In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies.

1991 ◽  
Vol 87 (6) ◽  
pp. 2222-2229 ◽  
Author(s):  
G R Freidenberg ◽  
S L Suter ◽  
R R Henry ◽  
D Reichart ◽  
J M Olefsky
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Human Skeletal Muscle ◽  
Glucose Disposal ◽  
Receptor Kinase ◽  
Euglycemic Clamp ◽  
Insulin Receptor Kinase ◽  
Stimulation Of

Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle

Diabetes ◽  
1994 ◽  
Vol 43 (1) ◽  
pp. 118-126 ◽  
Author(s):  
G. R. Freidenberg ◽  
S. Suter ◽  
R. R. Henry ◽  
J. Nolan ◽  
D. Reichart ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Human Skeletal Muscle ◽  
Receptor Kinase ◽  
Delayed Onset ◽  
Insulin Receptor Kinase

Delayed Onset of Insulin Activation of the Insulin Receptor Kinase In Vivo in Human Skeletal Muscle

Diabetes ◽  
1994 ◽  
Vol 43 (1) ◽  
pp. 118-126 ◽  
Author(s):  
G. R. Freidenberg ◽  
S. Suter ◽  
R. R. Henry ◽  
J. Nolan ◽  
D. Reichart ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Human Skeletal Muscle ◽  
Receptor Kinase ◽  
Delayed Onset ◽  
Insulin Receptor Kinase

In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency

1995 ◽  
Vol 268 (1) ◽  
pp. E60-E66 ◽  
Author(s):  
A. P. Bevan ◽  
J. W. Burgess ◽  
J. F. Yale ◽  
P. G. Drake ◽  
D. Lachance ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Glycogen Synthesis ◽  
Insulin Receptors ◽  
Receptor Kinase ◽  
Rat Diaphragm ◽  
Insulin Mimetic ◽  
Integrated Response ◽  
Insulin Receptor Kinase

Peroxovanadium (pV) compounds activate the insulin receptor kinase in hepatocytes and inhibit the dephosphorylation of insulin receptors in hepatic endosomes with highly correlated potencies (Posner, B. I., R. Faure, J. W. Burgess, A. P. Bevan, D. Lachance, G. Zhang-Sun, J. B. Ng, D. A. Hall, B. S. Lum, and A. Shaver J. Biol. Chem. 269: 4596–4604, 1994). After intravenous administration, K2[VO(O2)2(picolinato)].2H2O [bpV(pic)], VO(O2) (picolinato) (H2O)2 [mpV(pic)], K[VO(O2)2(picolinato)].3H2O [bpV(phen)], and K[VO(O2)2(4,7-dimethyl-1,10-phenanthroline)].1/2H2O [bpV(Me2phen)] produced 50% of their maximal hypoglycemic effect at doses of 0.04, 0.04, 0.32, and 0.65 mumol/100 g body wt, respectively. In contrast, their potencies as inhibitors of dephosphorylation were bpV(pic) = bpV(phen) > mpV(pic) = bpV(Me2phen). bpV(pic) stimulated [14C]glucose incorporation into rat diaphragm glycogen in vivo, and its effect was dose dependent, synergistic with insulin, and evident in other skeletal muscles. In contrast, bpV(phen) displayed no effect on glycogen synthesis in skeletal muscle. mpV(pic) stimulated and bpV(Me2phen) had no effect on glycogen synthesis in the diaphragm. bpV(pic) augmented rat diaphragm insulin receptor kinase 2.2-fold with a time-integrated response 70% that of insulin. In contrast, the effect of bpV(phen) was delayed and much reduced. Thus, the in vivo potencies of pV compounds reflect differing capacities to act on skeletal muscle. The ancillary ligand within the pV complex may target one tissue in preference to another.

scholarly journals Insulin receptor kinase in human skeletal muscle

FEBS Letters ◽  
1985 ◽  
Vol 186 (1) ◽  
pp. 85-88 ◽  
Author(s):  
B. Obermaier ◽  
B. Ermel ◽  
E. Biemer ◽  
D. Kirsch ◽  
F. Machicao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Human Skeletal Muscle ◽  
Receptor Kinase ◽  
Insulin Receptor Kinase

scholarly journals Internalization and Activation of the Rat Liver Insulin Receptor Kinase in vivo

1989 ◽  
Vol 264 (22) ◽  
pp. 12931-12940 ◽  
Author(s):  
M N Khan ◽  
G Baquiran ◽  
C Brule ◽  
J Burgess ◽  
B Foster ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Rat Liver ◽  
Receptor Kinase ◽  
Insulin Receptor Kinase
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