scholarly journals Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

1987 ◽  
Vol 79 (5) ◽  
pp. 1330-1337 ◽  
Author(s):  
J F Caro ◽  
M K Sinha ◽  
S M Raju ◽  
O Ittoop ◽  
W J Pories ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Human Skeletal Muscle ◽  
Receptor Kinase ◽  
Obese Subjects ◽  
Insulin Receptor Kinase

Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle

Diabetes ◽  
1994 ◽  
Vol 43 (1) ◽  
pp. 118-126 ◽  
Author(s):  
G. R. Freidenberg ◽  
S. Suter ◽  
R. R. Henry ◽  
J. Nolan ◽  
D. Reichart ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Human Skeletal Muscle ◽  
Receptor Kinase ◽  
Delayed Onset ◽  
Insulin Receptor Kinase

scholarly journals Insulin receptor kinase in human skeletal muscle

FEBS Letters ◽  
1985 ◽  
Vol 186 (1) ◽  
pp. 85-88 ◽  
Author(s):  
B. Obermaier ◽  
B. Ermel ◽  
E. Biemer ◽  
D. Kirsch ◽  
F. Machicao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Human Skeletal Muscle ◽  
Receptor Kinase ◽  
Insulin Receptor Kinase

Delayed Onset of Insulin Activation of the Insulin Receptor Kinase In Vivo in Human Skeletal Muscle

Diabetes ◽  
1994 ◽  
Vol 43 (1) ◽  
pp. 118-126 ◽  
Author(s):  
G. R. Freidenberg ◽  
S. Suter ◽  
R. R. Henry ◽  
J. Nolan ◽  
D. Reichart ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Human Skeletal Muscle ◽  
Receptor Kinase ◽  
Delayed Onset ◽  
Insulin Receptor Kinase

Insulin receptor kinase is hyperresponsive in adipocytes of young obese Zucker rats

1987 ◽  
Vol 252 (2) ◽  
pp. E273-E278 ◽  
Author(s):  
A. Debant ◽  
M. Guerre-Millo ◽  
Y. Le Marchand-Brustel ◽  
P. Freychet ◽  
M. Lavau ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Receptor ◽  
Insulin Action ◽  
Kinase Activity ◽  
Insulin Receptors ◽  
Zucker Rats ◽  
Receptor Kinase ◽  
Insulin Receptor Tyrosine Kinase ◽  
Obese Zucker Rats ◽  
Insulin Receptor Kinase

Thirty-day-old obese Zucker rats have hyperresponsive adipose tissue, whereas their skeletal muscle normally responds to insulin in vitro. To further substantiate the role of insulin receptor tyrosine kinase in insulin action, we have studied the kinase activity of receptors obtained from adipocytes and skeletal muscle of these young obese Zucker rats. Insulin receptors, partially purified by wheat germ agglutinin agarose chromatography from plasma membranes of isolated adipocytes or from skeletal muscles, were studied in a cell-free system for auto-phosphorylation and for their ability to phosphorylate a synthetic glutamate-tyrosine copolymer. For an identical amount of receptors, the insulin stimulatory action on its beta-subunit receptor phosphorylation was markedly augmented in preparations from hyperresponsive adipocytes of obese animals compared with lean rats. Basal phosphorylation of adipocyte insulin receptors was nearly identical in lean and obese animals. Similarly the capacity of adipocyte insulin receptors to catalyze the phosphorylation of the synthetic substrate in response to insulin was increased. By contrast, the kinase activity of insulin receptors prepared from normally insulin-responsive skeletal muscle was similar in preparations of lean and obese rats. These results show that a state of hyperresponsiveness to insulin is correlated with a parallel increase of insulin receptor kinase activity suggesting an important role for this activity in insulin action.

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