scholarly journals Mechanisms of gallstone formation in women. Effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolism.

1991 ◽  
Vol 87 (1) ◽  
pp. 237-246 ◽  
Author(s):  
G T Everson ◽  
C McKinley ◽  
F Kern
Keyword(s):  
Lipid Metabolism ◽  
Dietary Cholesterol ◽  
Gallstone Formation ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Exogenous Estrogen

scholarly journals The G protein-coupled receptor G2A: Involvement in hepatic lipid metabolism and gallstone formation in mice

Hepatology ◽  
2008 ◽  
Vol 48 (4) ◽  
pp. 1138-1148 ◽  
Author(s):  
Laura E. Johnson ◽  
Marc S. Elias ◽  
David T. Bolick ◽  
Marcus D. Skaflen ◽  
Richard M. Green ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
G Protein ◽  
Gallstone Formation ◽  
G Protein Coupled Receptor ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
G Protein Coupled

scholarly journals Circadian Rhythm Disruption Influenced Hepatic Lipid Metabolism, Gut Microbiota and Promoted Cholesterol Gallstone Formation in Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Chuanqi He ◽  
Weiyi Shen ◽  
Chaobo Chen ◽  
Qihan Wang ◽  
Qifan Lu ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Lipid Metabolism ◽  
Bile Acid ◽  
Gut Microbiota ◽  
Cholesterol Metabolism ◽  
Gallstone Formation ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Lithogenic Diet ◽  
Circadian Expression

BackgroundHepatic lipid metabolism regulates biliary composition and influences the formation of cholesterol gallstones. The genes Hmgcr and Cyp7a1, which encode key liver enzymes, are regulated by circadian rhythm-related transcription factors. We aimed to investigate the effect of circadian rhythm disruption on hepatic cholesterol and bile acid metabolism and the incidence of cholesterol stone formation.MethodsAdult male C57BL/6J mice were fed either a lithogenic diet (LD) only during the sleep phase (time-restricted lithogenic diet feeding, TRF) or an LD ad libitum (non-time-restricted lithogenic diet feeding, nTRF) for 4 weeks. Food consumption, body mass gain, and the incidence of gallstones were assessed. Circulating metabolic parameters, lipid accumulation in the liver, the circadian expression of hepatic clock and metabolic genes, and the gut microbiota were analyzed.ResultsTRF caused a dysregulation of the circadian rhythm in the mice, characterized by significant differences in the circadian expression patterns of clock-related genes. In TRF mice, the circadian rhythms in the expression of genes involved in bile acid and cholesterol metabolism were disrupted, as was the circadian rhythm of the gut microbiota. These changes were associated with high biliary cholesterol content, which promoted gallstone formation in the TRF mice.ConclusionDisordered circadian rhythm is associated with abnormal hepatic bile acid and cholesterol metabolism in mice, which promotes gallstone formation.

Altered hepatic lipid metabolism in leptin-deficlent mice

2001 ◽  
Vol 120 (5) ◽  
pp. A546-A546
Author(s):  
D SWARTZBASILE ◽  
M GOLDBLATT ◽  
C SVATEK ◽  
M WALTERS ◽  
S CHOI ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

Prenatal programming of hepatic lipid metabolism: Sex, hormones and lifelong health

2020 ◽  
Author(s):  
Katarzyna Siemienowicz ◽  
Panagiotis Filis ◽  
Chiara Talia ◽  
Jennifer Thomas ◽  
Paul Fowler ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Sex Hormones ◽  
Prenatal Programming ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid
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