scholarly journals The G protein-coupled receptor G2A: Involvement in hepatic lipid metabolism and gallstone formation in mice

Hepatology ◽  
2008 ◽  
Vol 48 (4) ◽  
pp. 1138-1148 ◽  
Author(s):  
Laura E. Johnson ◽  
Marc S. Elias ◽  
David T. Bolick ◽  
Marcus D. Skaflen ◽  
Richard M. Green ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
G Protein ◽  
Gallstone Formation ◽  
G Protein Coupled Receptor ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
G Protein Coupled

scholarly journals Neuronal control of lipid metabolism by STR‐2 G protein‐coupled receptor promotes longevity in Caenorhabditis elegans

Aging Cell ◽  
2020 ◽  
Vol 19 (6) ◽  
Author(s):  
Anubhuti Dixit ◽  
Anjali Sandhu ◽  
Souvik Modi ◽  
Meghana Shashikanth ◽  
Sandhya P. Koushika ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Neuronal Control ◽  
G Protein Coupled

scholarly journals A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: Loss of boss causes abnormal energy metabolism

2008 ◽  
Vol 105 (40) ◽  
pp. 15328-15333 ◽  
Author(s):  
Ayako Kohyama-Koganeya ◽  
Yeon-Jeong Kim ◽  
Masayuki Miura ◽  
Yoshio Hirabayashi
Keyword(s):  
Lipid Metabolism ◽  
G Protein ◽  
Insulin Signaling ◽  
Metabolic Regulation ◽  
Transmembrane Domain ◽  
Fat Body ◽  
Nutrient Sensing ◽  
G Protein Coupled Receptor ◽  
Extracellular Glucose ◽  
G Protein Coupled

Glucose, one of the most important nutrients for animals, acts as a regulatory signal that controls the secretion of hormones, such as insulin, by endocrine tissues. However, how organisms respond to extracellular glucose and how glucose controls nutrient homeostasis remain unknown. Here, we show that a putative Drosophila melanogaster G protein-coupled receptor, previously identified as Bride of sevenless (BOSS), responds to extracellular glucose and regulates sugar and lipid metabolism. We found that BOSS was expressed in the fat body, a nutrient-sensing tissue equivalent to mammalian liver and adipose tissues, and in photoreceptor cells. Boss null mutants had small bodies, exhibited abnormal sugar and lipid metabolism (elevated circulating sugar and lipid levels, impaired lipid mobilization to oenocytes), and were sensitive to nutrient deprivation stress. These phenotypes are reminiscent of flies defective in insulin signaling. Consistent with these findings are the observations that boss mutants had reduced PI3K activity and phospho-AKT levels, which indicates that BOSS is required for proper insulin signaling. Because human G protein-coupled receptor 5B and the seven-transmembrane domain of BOSS share the same sequence, our results also have important implications for glucose metabolism in humans. Thus, our study provides insight not only into the basic mechanisms of metabolic regulation but also into the pathobiological basis for diabetes and obesity.

scholarly journals Circadian Rhythm Disruption Influenced Hepatic Lipid Metabolism, Gut Microbiota and Promoted Cholesterol Gallstone Formation in Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Chuanqi He ◽  
Weiyi Shen ◽  
Chaobo Chen ◽  
Qihan Wang ◽  
Qifan Lu ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Lipid Metabolism ◽  
Bile Acid ◽  
Gut Microbiota ◽  
Cholesterol Metabolism ◽  
Gallstone Formation ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Lithogenic Diet ◽  
Circadian Expression

BackgroundHepatic lipid metabolism regulates biliary composition and influences the formation of cholesterol gallstones. The genes Hmgcr and Cyp7a1, which encode key liver enzymes, are regulated by circadian rhythm-related transcription factors. We aimed to investigate the effect of circadian rhythm disruption on hepatic cholesterol and bile acid metabolism and the incidence of cholesterol stone formation.MethodsAdult male C57BL/6J mice were fed either a lithogenic diet (LD) only during the sleep phase (time-restricted lithogenic diet feeding, TRF) or an LD ad libitum (non-time-restricted lithogenic diet feeding, nTRF) for 4 weeks. Food consumption, body mass gain, and the incidence of gallstones were assessed. Circulating metabolic parameters, lipid accumulation in the liver, the circadian expression of hepatic clock and metabolic genes, and the gut microbiota were analyzed.ResultsTRF caused a dysregulation of the circadian rhythm in the mice, characterized by significant differences in the circadian expression patterns of clock-related genes. In TRF mice, the circadian rhythms in the expression of genes involved in bile acid and cholesterol metabolism were disrupted, as was the circadian rhythm of the gut microbiota. These changes were associated with high biliary cholesterol content, which promoted gallstone formation in the TRF mice.ConclusionDisordered circadian rhythm is associated with abnormal hepatic bile acid and cholesterol metabolism in mice, which promotes gallstone formation.

Altered hepatic lipid metabolism in leptin-deficlent mice

2001 ◽  
Vol 120 (5) ◽  
pp. A546-A546
Author(s):  
D SWARTZBASILE ◽  
M GOLDBLATT ◽  
C SVATEK ◽  
M WALTERS ◽  
S CHOI ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid
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