scholarly journals Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vitro.

1988 ◽  
Vol 82 (3) ◽  
pp. 839-846 ◽  
Author(s):  
A E Calogero ◽  
W T Gallucci ◽  
G P Chrousos ◽  
P W Gold
Keyword(s):  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Immobilization stress rapidly decreases hypothalamic corticotropin-releasing hormone secretion in vitro in the male 344/N Fischer rat

Life Sciences ◽  
1993 ◽  
Vol 53 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Giovanni Cizza ◽  
Richard Kvetnansky ◽  
Maria E. Tartaglia ◽  
Marc R. Blackman ◽  
George P. Chrousos ◽  
...  
Keyword(s):  
Immobilization Stress ◽  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Interaction between GABAergic neurotransmission and rat hypothalamic corticotropin-releasing hormone secretion in vitro

1988 ◽  
Vol 463 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Aldo E. Calogero ◽  
William T. Gallucci ◽  
George P. Chrousos ◽  
Philip W. Gold
Keyword(s):  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Gabaergic Neurotransmission ◽  
Releasing Hormone

Arachidonic Acid Metabolites Modulate Rat Hypothalamic Corticotropin-Releasing Hormone Secretion in vitro

1989 ◽  
Vol 50 (6) ◽  
pp. 708-715 ◽  
Author(s):  
Renato Bernardini ◽  
Andrea Chiarenza ◽  
Aldo E. Calogero ◽  
Philip W. Gold ◽  
George P. Chrousos
Keyword(s):  
Arachidonic Acid ◽  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Arachidonic Acid Metabolites ◽  
Acid Metabolites

Effect of Cholinergic Agonists and Antagonists on Rat Hypothalamic Corticotropin-Releasing Hormone Secretion in vitro

1988 ◽  
Vol 47 (4) ◽  
pp. 303-308 ◽  
Author(s):  
Aldo E. Calogero ◽  
William T. Gallucci ◽  
Renato Bernardini ◽  
Christina Saoutis ◽  
Philip W. Gold ◽  
...  
Keyword(s):  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Cholinergic Agonists ◽  
Releasing Hormone ◽  
Cholinergic Agonists And Antagonists

Hypocretin/orexin suppresses corticotroph responsiveness in vitro

2001 ◽  
Vol 281 (4) ◽  
pp. R1140-R1145 ◽  
Author(s):  
Willis K. Samson ◽  
Meghan M. Taylor
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Hormone Secretion ◽  
Anterior Pituitary Gland ◽  
Affinity Constant ◽  
Corticotropin Releasing Hormone ◽  
Acth Secretion ◽  
Orexin A ◽  
Releasing Hormone

The hypocretin/orexins (Hcrts/ORXs) are peptides produced in neurons in the lateral hypothalamic area that project to neuroendocrine centers in the hypothalamus. Hcrt/ORX receptors are present in the hypothalamus and anterior pituitary gland. We examined the possibility that the Hcrts/ORXs, which we have demonstrated previously to act in the brain to stimulate sympathetic function, could alter stress hormone secretion by a direct pituitary action. In vitro studies revealed a dose-related inhibitory effect of the Hcrts/ORXs on corticotropin-releasing hormone-stimulated ACTH secretion that appeared to be mediated via the orexin-1 receptor and to be expressed at doses (threshold dose 1 nM orexin A) similar to the affinity constant for the receptor. The effect was not due to abrogation of the cAMP response of the corticotroph to corticotropin-releasing hormone and was not pertussis toxin sensitive, suggesting a non-Gi-mediated mechanism. Instead, a Gq-mediated signaling mechanism was indicated by the ability of protein kinase C blockade with calphostin C to reverse the inhibitory action of orexin A. Orexin A and orexin B did not significantly alter basal ACTH secretion in vitro and did not alter basal or releasing factor-stimulated secretion of luteinizing hormone, prolactin, thyroid-stimulating hormone or growth hormone from cells harvested from male or random-cycle female donors. Our data suggest a direct, pituitary action of the Hcrts/ORXs to modulate the endocrine response to stress and identify the potential cellular mechanism of a unique biological action of the peptides in the anterior pituitary gland.

Cocaine stimulates rat hypothalamic corticotropin-releasing hormone secretion in vitro

1989 ◽  
Vol 505 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Aldo E. Calogero ◽  
William T. Gallucci ◽  
Mitchel A. Kling ◽  
George P. Chrousos ◽  
Philip W. Gold
Keyword(s):  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Involvement of H1 Histamine Receptor in Basal and Estrogen-Stimulated Luteinizing Hormone-Releasing Hormone Secretion in Rats in vitro

1987 ◽  
Vol 45 (3) ◽  
pp. 191-196 ◽  
Author(s):  
Akira Miyake ◽  
Shirou Ohtsuka ◽  
Takamichi Nishizaki ◽  
Keiichi Tasaka ◽  
Toshihiro Aono ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Secretion ◽  
Histamine Receptor ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone

Regulation of CRH-induced secretion of ACTH and corticosterone by SOM230 in rats

2005 ◽  
Vol 153 (3) ◽  
pp. R7-R10 ◽  
Author(s):  
A P Silva ◽  
P Schoeffter ◽  
G Weckbecker ◽  
C Bruns ◽  
H A Schmid
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Plasma Concentrations ◽  
Inhibitory Effect ◽  
Corticotropin Releasing Hormone ◽  
Acth Secretion ◽  
Releasing Hormone ◽  
Corticosterone Secretion ◽  
Corticosterone Release ◽  
Acth Release

Objective: Adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome is biochemically characterized by increased plasma concentrations of ACTH inducing hypersecretion of cortisol. Somatostatin is known to inhibit ACTH secretion, and in vitro data have shown the inhibition of ACTH secretion by agonists activating sst2 and sst5 receptors. The present study aimed to determine the inhibitory effect of the multireceptor ligand SOM230, compared with the sst2-preferring agonist octreotide, on corticotropin-releasing hormone (CRH)-stimulated secretion of ACTH and corticosterone in rats. Methods: Secretion of ACTH and corticosterone was induced by i.v. application of CRH (0.5 μg/kg) in rats pretreated 1 h before by i.v. application of SOM230 (1, 3, or 10 μg/kg), octreotide (10 μg/kg) or NaCl 0.9%. Results: SOM230 (3 and 10 μg/kg) inhibited CRH-induced ACTH release by 45±3% and 51±2%, respectively, and corticosterone release by 43±5% and 27±16%, respectively. 10 μg/kg of octreotide tended to be less potent at inhibiting ACTH release (34±6% inhibition) and did not alter the secretion of corticosterone. Conclusion: SOM230 has a stronger inhibitory effect on ACTH and corticosterone secretion than octreotide in rats. This difference can be explained by its higher affinity to sst1, sst3 and especially sst5 receptors compared with octreotide.

Sign in / Sign up

Export Citation Format

Share Document