Effect of Cholinergic Agonists and Antagonists on Rat Hypothalamic Corticotropin-Releasing Hormone Secretion in vitro

1988 ◽  
Vol 47 (4) ◽  
pp. 303-308 ◽  
Author(s):  
Aldo E. Calogero ◽  
William T. Gallucci ◽  
Renato Bernardini ◽  
Christina Saoutis ◽  
Philip W. Gold ◽  
...  
Keyword(s):  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Cholinergic Agonists ◽  
Releasing Hormone ◽  
Cholinergic Agonists And Antagonists

Immobilization stress rapidly decreases hypothalamic corticotropin-releasing hormone secretion in vitro in the male 344/N Fischer rat

Life Sciences ◽  
1993 ◽  
Vol 53 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Giovanni Cizza ◽  
Richard Kvetnansky ◽  
Maria E. Tartaglia ◽  
Marc R. Blackman ◽  
George P. Chrousos ◽  
...  
Keyword(s):  
Immobilization Stress ◽  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Interaction between GABAergic neurotransmission and rat hypothalamic corticotropin-releasing hormone secretion in vitro

1988 ◽  
Vol 463 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Aldo E. Calogero ◽  
William T. Gallucci ◽  
George P. Chrousos ◽  
Philip W. Gold
Keyword(s):  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Gabaergic Neurotransmission ◽  
Releasing Hormone

Arachidonic Acid Metabolites Modulate Rat Hypothalamic Corticotropin-Releasing Hormone Secretion in vitro

1989 ◽  
Vol 50 (6) ◽  
pp. 708-715 ◽  
Author(s):  
Renato Bernardini ◽  
Andrea Chiarenza ◽  
Aldo E. Calogero ◽  
Philip W. Gold ◽  
George P. Chrousos
Keyword(s):  
Arachidonic Acid ◽  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Arachidonic Acid Metabolites ◽  
Acid Metabolites

scholarly journals Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vitro.

1988 ◽  
Vol 82 (3) ◽  
pp. 839-846 ◽  
Author(s):  
A E Calogero ◽  
W T Gallucci ◽  
G P Chrousos ◽  
P W Gold
Keyword(s):  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Cholinergic modulation of CRH and non-CRH neurons in Barrington’s nucleus of the mouse

2020 ◽  
Vol 124 (2) ◽  
pp. 443-457
Author(s):  
Masahiro Kawatani ◽  
Keiichi Itoi ◽  
Ashraf Hossain Talukder ◽  
Katsuya Uchida ◽  
Kenji Sakimura ◽  
...  
Keyword(s):  
Muscarinic Receptors ◽  
Nicotinic Receptors ◽  
Corticotropin Releasing Hormone ◽  
Cholinergic Modulation ◽  
Cholinergic Agonists ◽  
Releasing Hormone

This study investigates the effects of bath-applied cholinergic agonists on Barrington’s nucleus (BarN) neurons in vitro. They were either excitatory, through nicotinic receptors, or inhibitory, through muscarinic receptors. Putative corticotropin-releasing hormone (CRH)-expressing neurons in BarN, as well as putative non-CRH-expressing neurons, responded to cholinergic agonists.

Hypocretin/orexin suppresses corticotroph responsiveness in vitro

2001 ◽  
Vol 281 (4) ◽  
pp. R1140-R1145 ◽  
Author(s):  
Willis K. Samson ◽  
Meghan M. Taylor
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Hormone Secretion ◽  
Anterior Pituitary Gland ◽  
Affinity Constant ◽  
Corticotropin Releasing Hormone ◽  
Acth Secretion ◽  
Orexin A ◽  
Releasing Hormone

The hypocretin/orexins (Hcrts/ORXs) are peptides produced in neurons in the lateral hypothalamic area that project to neuroendocrine centers in the hypothalamus. Hcrt/ORX receptors are present in the hypothalamus and anterior pituitary gland. We examined the possibility that the Hcrts/ORXs, which we have demonstrated previously to act in the brain to stimulate sympathetic function, could alter stress hormone secretion by a direct pituitary action. In vitro studies revealed a dose-related inhibitory effect of the Hcrts/ORXs on corticotropin-releasing hormone-stimulated ACTH secretion that appeared to be mediated via the orexin-1 receptor and to be expressed at doses (threshold dose 1 nM orexin A) similar to the affinity constant for the receptor. The effect was not due to abrogation of the cAMP response of the corticotroph to corticotropin-releasing hormone and was not pertussis toxin sensitive, suggesting a non-Gi-mediated mechanism. Instead, a Gq-mediated signaling mechanism was indicated by the ability of protein kinase C blockade with calphostin C to reverse the inhibitory action of orexin A. Orexin A and orexin B did not significantly alter basal ACTH secretion in vitro and did not alter basal or releasing factor-stimulated secretion of luteinizing hormone, prolactin, thyroid-stimulating hormone or growth hormone from cells harvested from male or random-cycle female donors. Our data suggest a direct, pituitary action of the Hcrts/ORXs to modulate the endocrine response to stress and identify the potential cellular mechanism of a unique biological action of the peptides in the anterior pituitary gland.

Cocaine stimulates rat hypothalamic corticotropin-releasing hormone secretion in vitro

1989 ◽  
Vol 505 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Aldo E. Calogero ◽  
William T. Gallucci ◽  
Mitchel A. Kling ◽  
George P. Chrousos ◽  
Philip W. Gold
Keyword(s):  
Hormone Secretion ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone
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