scholarly journals Bile acid synthesis in man. In vivo activity of the 25-hydroxylation pathway.

1988 ◽  
Vol 82 (1) ◽  
pp. 82-85 ◽  
Author(s):  
W C Duane ◽  
P A Pooler ◽  
J N Hamilton
Keyword(s):  
Bile Acid ◽  
Acid Synthesis ◽  
Bile Acid Synthesis

scholarly journals Biogeography of microbial bile acid transformations along the murine gut

2020 ◽  
Vol 61 (11) ◽  
pp. 1450-1463 ◽  
Author(s):  
Solenne Marion ◽  
Lyne Desharnais ◽  
Nicolas Studer ◽  
Yuan Dong ◽  
Matheus D. Notter ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Bile Acid Pool Size ◽  
Host Signaling ◽  
Gut Microorganisms ◽  
Gut Microbial Community

Bile acids, which are synthesized from cholesterol by the liver, are chemically transformed along the intestinal tract by the gut microbiota, and the products of these transformations signal through host receptors, affecting overall host health. These transformations include bile acid deconjugation, oxidation, and 7α-dehydroxylation. An understanding of the biogeography of bile acid transformations in the gut is critical because deconjugation is a prerequisite for 7α-dehydroxylation and because most gut microorganisms harbor bile acid transformation capacity. Here, we used a coupled metabolomic and metaproteomic approach to probe in vivo activity of the gut microbial community in a gnotobiotic mouse model. Results revealed the involvement of Clostridium scindens in 7α-dehydroxylation, of the genera Muribaculum and Bacteroides in deconjugation, and of six additional organisms in oxidation (the genera Clostridium, Muribaculum, Bacteroides, Bifidobacterium, Acutalibacter, and Akkermansia). Furthermore, the bile acid profile in mice with a more complex microbiota, a dysbiosed microbiota, or no microbiota was considered. For instance, conventional mice harbor a large diversity of bile acids, but treatment with an antibiotic such as clindamycin results in the complete inhibition of 7α-dehydroxylation, underscoring the strong inhibition of organisms that are capable of carrying out this process by this compound. Finally, a comparison of the hepatic bile acid pool size as a function of microbiota revealed that a reduced microbiota affects host signaling but not necessarily bile acid synthesis. In this study, bile acid transformations were mapped to the associated active microorganisms, offering a systematic characterization of the relationship between microbiota and bile acid composition.

In vivo evaluation of bile acid synthesis in patients with cerebrotendinous xhantomatosis

2007 ◽  
Vol 149 ◽  
pp. S75-S76 ◽  
Author(s):  
Marina Del Puppo ◽  
Federica Corna ◽  
Maria Teresa Dotti ◽  
Emma De Fabiani ◽  
Marzia Galli Kienle
Keyword(s):  
Bile Acid ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
In Vivo Evaluation

Suppression of in vivo bile acid synthesis, but not of in vitro cholesterol 7α-hydroxylase expression, by biliary obstruction in humans

2000 ◽  
Vol 32 ◽  
pp. 121
Author(s):  
M. Bertolotti ◽  
L. Carulli ◽  
M. Concari ◽  
P. Martella ◽  
P. Loria ◽  
...  
Keyword(s):  
Bile Acid ◽  
Biliary Obstruction ◽  
Acid Synthesis ◽  
Bile Acid Synthesis

Effect of chronic ethanol administration on cholesterol and bile acid synthesis in vivo

Lipids ◽  
1978 ◽  
Vol 13 (2) ◽  
pp. 134-136 ◽  
Author(s):  
M. R. Lakshman ◽  
Atam D. Gupta ◽  
Richard L. Veech
Keyword(s):  
Bile Acid ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Chronic Ethanol Administration

scholarly journals Hypolipidemic Roles of Casein-Derived Peptides by Regulation of Trans-Intestinal Cholesterol Excretion and Bile Acid Synthesis

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3058
Author(s):  
Sungmin Lee ◽  
BuHyun Youn
Keyword(s):  
Bile Acid ◽  
Bioactive Peptides ◽  
Oral Treatment ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
In Vivo Models ◽  
Intestinal Excretion ◽  
Cholesterol Excretion

Hyperlipidemia, a syndrome characterized by an abnormal elevation of blood lipids, causes chronic lethal metabolic disorders. Although statins are regularly prescribed to patients, an alternative to treat the burden of excessive lipids is required for cholesterol control. In this study, it was found that the treatment of casein hydrolyzed by pepsin and trypsin induced trans-intestinal cholesterol excretion (TICE) through ATP-binding cassette subfamily G members 5 (ABCG5) expression. Next, we analyzed sequences of the peptides responsible for TICE induction, synthesized artificial peptides based on the sequences, and the hypolipidemic effects of the peptide treatments were assessed in both in vitro and in vivo models. We determined that two bioactive peptides contained in casein hydrolysates (SQSKVLPVPQK and HPHPHLSF) induced TICE through the expression of ABCG5 in enterocytes and suppressed hepatic mRNA expression of cytochrome P450 family 7 subfamily A member 1 (CYP7A1) and CYP8B1by ileal FGF19 expression both in an liver X receptor α (LXRα)-mediated manner. In the hyperlipidemic mouse models, the oral administration of peptides reduced serum cholesterol levels through elevation of the ABCG5 expression in proximal intestine and fecal cholesterol secretion. Besides this, peptides induced ileal expression of fibroblast growth factor 15/19 (FGF15/19) and inhibited hepatic bile acid synthesis. We found that the oral treatment of casein-derived bioactive peptides could improve hyperlipidemia by regulating intestinal excretion and hepatic synthesis of cholesterols.

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