scholarly journals A human lung mast cell chymotrypsin-like enzyme. Identification and partial characterization.

1986 ◽  
Vol 77 (1) ◽  
pp. 196-201 ◽  
Author(s):  
B U Wintroub ◽  
C E Kaempfer ◽  
N M Schechter ◽  
D Proud
Keyword(s):  
Mast Cell ◽  
Human Lung ◽  
Partial Characterization ◽  
Lung Mast Cell

scholarly journals The human lung mast cell.

1984 ◽  
Vol 55 ◽  
pp. 259-269 ◽  
Author(s):  
S I Wasserman
Keyword(s):  
Mast Cell ◽  
Human Lung ◽  
Lung Mast Cell

Attenuation of human lung mast cell degranulation by bronchial epithelium

Allergy ◽  
2006 ◽  
Vol 61 (5) ◽  
pp. 569-575 ◽  
Author(s):  
W. Yang ◽  
A. J. Wardlaw ◽  
P. Bradding
Keyword(s):  
Mast Cell ◽  
Human Lung ◽  
Bronchial Epithelium ◽  
Mast Cell Degranulation ◽  
Lung Mast Cell

Mast cells express IL-13Rα1: IL-13 promotes human lung mast cell proliferation and FcɛRI expression

Allergy ◽  
2006 ◽  
Vol 61 (9) ◽  
pp. 1047-1053 ◽  
Author(s):  
D. Kaur ◽  
F. Hollins ◽  
L. Woodman ◽  
W. Yang ◽  
P. Monk ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mast Cell ◽  
Mast Cells ◽  
Human Lung ◽  
Lung Mast Cell

scholarly journals Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation

2006 ◽  
Vol 147 (7) ◽  
pp. 707-713 ◽  
Author(s):  
Linda J Kay ◽  
Wilfred W Yeo ◽  
Peter T Peachell
Keyword(s):  
Mast Cell ◽  
Prostaglandin E2 ◽  
Human Lung ◽  
Mast Cell Degranulation ◽  
Lung Mast Cell

scholarly journals Human Lung Mast Cell Products Regulate Airway Smooth Muscle CXCL10 Levels

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
H. Alkhouri ◽  
V. Cha ◽  
K. Tong ◽  
L. M. Moir ◽  
C. L. Armour ◽  
...  
Keyword(s):  
Mast Cell ◽  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Human Lung ◽  
Serine Protease Inhibitor ◽  
Receptor Activation ◽  
Mrna Levels ◽  
Free System ◽  
A Cell ◽  
Lung Mast Cell

In asthma, the airway smooth muscle (ASM) produces CXCL10 which may attract CXCR3+ mast/T cells to it. Our aim was to investigate the effects of mast cell products on ASM cell CXCL10 production. ASM cells from people with and without asthma were stimulated with IL-1β, TNF-α, and/or IFNγ and treated with histamine (1–100 μM) ± chlorpheniramine (H1R antagonist; 1 μM) or ranitidine (H2R antagonist; 50 μM) or tryptase (1 nM) ± leupeptin (serine protease inhibitor; 50 μM), heat-inactivated tryptase, or vehicle for 4 h or 24 h. Human lung mast cells (MC) were isolated and activated with IgE/anti-IgE and supernatants were collected after 2 h or 24 h. The supernatants were added to ASM cells for 48 h and ASM cell CXCL10 production detected using ELISA (protein) and real-time PCR (mRNA). Histamine reduced IL-1β/TNF-α-induced CXCL10 protein, but not mRNA, levels independent of H1 and H2 receptor activation, whereas tryptase and MC 2 h supernatants reduced all cytokine-induced CXCL10. Tryptase also reduced CXCL10 levels in a cell-free system. Leupeptin inhibited the effects of tryptase and MC 2 h supernatants. MC 24 h supernatants contained TNF-α and amplified IFNγ-induced ASM cell CXCL10 production. This is the first evidence that MC can regulate ASM cell CXCL10 production and its degradation. Thus MC may regulate airway myositis in asthma.

scholarly journals IgE alone promotes human lung mast cell survival through the autocrine production of IL-6

2008 ◽  
Vol 9 (1) ◽  
pp. 2 ◽  
Author(s):  
Glenn Cruse ◽  
Sarah Cockerill ◽  
Peter Bradding
Keyword(s):  
Mast Cell ◽  
Cell Survival ◽  
Human Lung ◽  
Lung Mast Cell
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