scholarly journals Adenosine Potentiates Human Lung Mast Cell Tissue Plasminogen Activator Activity

2010 ◽  
Vol 186 (2) ◽  
pp. 1209-1217 ◽  
Author(s):  
Michal J. Sereda ◽  
Peter Bradding ◽  
Catherine Vial
Keyword(s):  
Mast Cell ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Human Lung ◽  
Plasminogen Activator Activity ◽  
Cell Tissue ◽  
Tissue Plasminogen ◽  
Lung Mast Cell

Ontogenesis of Tissue Plasminogen Activator in the Human

1971 ◽  
Vol 25 (03) ◽  
pp. 469-480 ◽  
Author(s):  
B Åstedt ◽  
M Pandolfi
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Vena Cava ◽  
Vasa Vasorum ◽  
Moderate Activity ◽  
Foetal Development ◽  
Plasminogen Activator Activity ◽  
Stage Of Development ◽  
Tissue Plasminogen ◽  
Enzyme Pattern

SummaryThe ontogenesis of tissue plasminogen activator in various tissues was studied in 10 embryos and 58 foetuses with a histochemical method.The first appearance of activator activity was seen in a 4-weeks old embryo. At 8-9 weeks it was seen in the eye, meninges, heart, lungs, kidney and vena cava. In the foetal heart high activity was found in the coronary vessels, which can be regarded as the vasa vasorum of the heart. In the lungs a moderate activity increased at 24 weeks of age, when vascularisation increases more rapidly. Intense activity was seen in the highly vascularized corneoscleral junction of the eye later involved in the drainage of aqueous humor.In the kidney the activity could be related to the vessels, while no activity was seen in the glomeruli, the collecting system or the pelvis. In the vessels the activator activity was fairly high. No activity was seen in any stage of development of the liver.The plasminogen activator activity may be of importance for maintaining the foetomaternal circulation and micro-circulation in rapidly growing foetal organs. In the embryo the enzyme pattern is dominated by protein synthetizing enzymes. During foetal development the enzyme pattern changes owing to supervention of enzymes necessary for the function of the various organs. Plasminogen activator belongs to this latter group. The appearance of plasminogen activator activity may therefore be regarded mainly as a sign of functional maturity of the foetal organs.

The Antiangiogenic Agent Neovastat (Æ-941) Stimulates Tissue Plasminogen Activator Activity

2004 ◽  
Vol 22 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Denis Gingras ◽  
Dominique Labelle ◽  
Carine Nyalendo ◽  
Dominique Boivin ◽  
Michel Demeule ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Antiangiogenic Agent ◽  
Plasminogen Activator Activity ◽  
Tissue Plasminogen

Inhibitors Interfering with the Quantitative Estimation of Tissue Plasminogen Activator

1975 ◽  
Author(s):  
G. Wijngaards ◽  
A. T. Potjer
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Human Tissue ◽  
Inhibitory Action ◽  
Human Lung ◽  
Quantitative Estimation ◽  
Plasminogen Activators ◽  
Tissue Extracts ◽  
Tissue Plasminogen ◽  
Inhibitory Components

The commonly used quantitative assay for plasminogen activator in tissues by Astrup and Albrechtsen (1957) was re-evaluated with special reference to the presence of inhibitors in tissue extracts at different stages of the procedure.Human lung, liver, and placenta tissues were chosen for their different activator and inhibitor content. Samples of the extracts were tested for inhibitory capacity against purified human tissue plasminogen activator, urokinase, and plasmin on different kinds of fibrin plates.The procedure for preparing the samples according to Astrup and Albrechtsen did not completely eliminate the inhibitory action against the plasminogen activators added. The presence of inhibitors was partly obscured by 2M KCNS in the sample. In order to quantitate the plasminogen activator content in tissues, the method should be revised with respect to the elimination of inhibiting material.Some interesting aspects of the inhibitory components extracted from liver and placenta were revealed by comparing urokinase inhibition to tissue activator inhibition as to the degree of denaturation during the procedure. It was suggested that, although they have much in common, urokinase and tissue activator inhibitors are separate entities.

The effect of noise and starvation on the tissue plasminogen activator activity

1986 ◽  
Vol 42 (5) ◽  
pp. 717-718 ◽  
Author(s):  
E. Alexaki ◽  
N. Kokolis ◽  
Th. Ploumis ◽  
A. Smokovitis
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Plasminogen Activator Activity ◽  
Tissue Plasminogen

scholarly journals Tissue plasminogen activator and the development of spontaneous lung metastasis in nude mice hosts of transplanted human lung cancer cells.

Haigan ◽  
1988 ◽  
Vol 28 (7) ◽  
pp. 843-847
Author(s):  
Noriyuki Sagara ◽  
Keiji Nakano ◽  
Haruhiko Inufusa ◽  
Satoshi Hara ◽  
Masuo Aizawa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Lung Metastasis ◽  
Nude Mice ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells ◽  
Tissue Plasminogen
Sign in / Sign up

Export Citation Format

Share Document