scholarly journals Intravenous infusion of L-isomers of phenylalanine and tryptophan stimulate gastric acid secretion at physiologic plasma concentrations in normal subjects and after parietal cell vagotomy.

1983 ◽  
Vol 71 (5) ◽  
pp. 1254-1262 ◽  
Author(s):  
K E McArthur ◽  
J I Isenberg ◽  
D L Hogan ◽  
S J Dreier
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Parietal Cell ◽  
Intravenous Infusion ◽  
Plasma Concentrations ◽  
Normal Subjects ◽  
Parietal Cell Vagotomy

scholarly journals Relationship Between Gastric Acid Secretion and the Rate of Recurrent Ulcer After Parietal Cell Vagotomy

1993 ◽  
Vol 217 (3) ◽  
pp. 253-259 ◽  
Author(s):  
Frédéric Cohen ◽  
Patrice Valleur ◽  
Javier Serra ◽  
Denis Brisset ◽  
Laurence Chiche ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Parietal Cell ◽  
Recurrent Ulcer ◽  
Parietal Cell Vagotomy

scholarly journals Neurotensin induced inhibition of gastric acid secretion in duodenal ulcer patients before and after parietal cell vagotomy.

Gut ◽  
1984 ◽  
Vol 25 (5) ◽  
pp. 481-484 ◽  
Author(s):  
P S Olsen ◽  
J H Pedersen ◽  
P Kirkegaard ◽  
H Been ◽  
F Stadil ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Parietal Cell ◽  
Before And After ◽  
Parietal Cell Vagotomy

scholarly journals Gene expression profiling of gastrin target genes in parietal cells

2006 ◽  
Vol 24 (2) ◽  
pp. 124-132 ◽  
Author(s):  
Renu N. Jain ◽  
Cynthia S. Brunkan ◽  
Catherine S. Chew ◽  
Linda C. Samuelson
Keyword(s):  
Gene Expression ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Parietal Cell ◽  
Target Genes ◽  
Adaptor Protein ◽  
Parietal Cells ◽  
Cell Gene Expression ◽  
Cell Gene

Previous studies demonstrated that mice with a null mutation in the gene encoding the hormone gastrin have impaired gastric acid secretion. Hence, the aim of this study was to evaluate changes in the acid-secreting parietal cell in gastrin-deficient (GAS-KO) mice. Analysis of several transcripts encoding parietal cell proteins involved in gastric acid secretion showed reduced abundance in the GAS-KO stomach, including H+,K+-ATPase α- and β-subunits, KCNQ1 potassium channel, aquaporin-4 water channel, and creatine kinase B, which were reversed by gastrin infusion for 1 wk. Although mRNA and protein levels of LIM and SH3 domain-containing protein-1 (LASP-1) were not greatly changed in the mutant, there was a marked reduction in phosphorylation, consistent with its proposed role as a cAMP signal adaptor protein associated with acid secretion. A more comprehensive analysis of parietal cell gene expression in GAS-KO mice was performed using the Affymetrix U74AV2 chip with RNA from parietal cells purified by flow cytometry to >90%. Comparison of gene expression in GAS-KO and wild-type mice identified 47 transcripts that differed by greater than or equal to twofold, suggesting that gastrin affects parietal cell gene expression in a specific manner. The differentially expressed genes included several genes in signaling pathways, with a substantial number (20%) known to be target genes for Wnt and Myc.

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