scholarly journals Histocompatibility alloantigens in psoriasis and psoriatic arthritis. Evidence for the influence of multiple genes in the major histocompatibility complex.

1980 ◽  
Vol 66 (4) ◽  
pp. 670-675 ◽  
Author(s):  
C Murray ◽  
D L Mann ◽  
L N Gerber ◽  
W Barth ◽  
S Perlmann ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Psoriatic Arthritis ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Multiple Genes

High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis

2011 ◽  
Vol 70 (4) ◽  
pp. 690-694 ◽  
Author(s):  
Proton Rahman ◽  
Nicole M Roslin ◽  
Fawnda J Pellett ◽  
Mathieu Lemire ◽  
Celia M T Greenwood ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Psoriatic Arthritis ◽  
Genetic Locus ◽  
Ring Finger ◽  
Primary Objective ◽  
Nucleotide Polymorphisms ◽  
Major Histocompatibility ◽  
Hla Alleles ◽  
Familial Predisposition ◽  
Histocompatibility Complex

ObjectivePsoriatic arthritis (PsA) has a clear familial predisposition, the major histocompatibility complex (MHC) region being the strongest genetic locus. The study primary objective was to identify single nucleotide polymorphisms (SNPs) independent of known human leucocyte antigen (HLA) alleles within the MHC region that are associated with PsA using a high-density SNP map.MethodIn all, 914 samples were assessed, including 427 PsA cases from 2 well established PsA cohorts and 487 controls from Canada. The genotype data consisted of 2521 SNPs from 2 Illumina Goldengate MHC panels, spanning 4.9 Mb of chromosome 6 with an average spacing of 2 kb. Classical HLA alleles were genotyped in all subjects using sequence-specific oligonucleotide probes or sequence-specific primers. A conditioning approach was used to distinguish between new associations and those in linkage disequilibrium (LD) with known HLA alleles.ResultsUnconditional association analysis revealed 43 markers with p<7.26×10−5 (calculated experiment-wide significance threshold). In the conditional analysis, 10 SNPs showed statistically significant association at a threshold of p<7.26×10−5. Seven SNPs were in strong LD in the study data (pairwise r2 >0.77 in the controls) reflecting one association signal. These SNPs spanned a 1.6 Mb region. SNP rs1150735 is 1.5 kb upstream from ring finger protein 39 (RNF39). RNF39 SNPs have been associated with HIV1 disease progression and set point CD4 T cell count.ConclusionFour new loci for either psoriasis or PsA in the MHC region that are independent of known HLA alleles have been identified. The effect size of these variants is modest. Replication of these variants in multiple larger populations is necessary.

scholarly journals Clinical Differences between Men and Women with Psoriatic Arthritis: Relevance of the Analysis of Genes and Polymorphisms in the Major Histocompatibility Complex Region and of the Age at Onset of Psoriasis

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Rubén Queiro ◽  
Patricia Tejón ◽  
Pablo Coto ◽  
Sara Alonso ◽  
Mercedes Alperi ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Psoriatic Arthritis ◽  
Age At Onset ◽  
Joint Damage ◽  
Joint Involvement ◽  
Hormonal Changes ◽  
Major Histocompatibility ◽  
Genetic Associations ◽  
Men And Women ◽  
Histocompatibility Complex

It has been shown that males with spondyloarthritis tend to suffer from more severe spinal disease while females are more likely to have peripheral joint involvement. Nevertheless, gender-related differences have not been thoroughly explored in psoriatic arthritis (PsA). In PsA, males accumulate more peripheral and axial joint damage compared to women. However, it is not clear whether these findings are secondary to differences in occupational physical activity, hormonal changes, or other factors. The present study analyzed the differences in clinical expression of PsA between men and women. We have also evaluated the possible existence of gender-linked differences in the distribution of genes and polymorphisms within the major histocompatibility complex and whether patients’ age at the onset of psoriasis established any differences in these aspects. Women suffered more polyarthritis, greater functional impairment, and a larger number of swollen joints during followup. We appreciated a differential expression of certain MHC genes according to gender and age at onset of psoriasis. Our results point to the need to include patient’s age at the onset of psoriasis and gender as key stratification elements in future studies of genetic associations in PsA.

Sign in / Sign up

Export Citation Format

Share Document