Genetic and Clinical Description of Hemochromatosis Probands and Heterozygotes: Evidence That Multiple Genes Linked to the Major Histocompatibility Complex Are Responsible for Hemochromatosis

1997 ◽  
Vol 23 (1) ◽  
pp. 135-145 ◽  
Author(s):  
James C. Barton ◽  
Wendy W.H. Shih ◽  
Ritsuko Sawada-Hirai ◽  
Ronald T. Acton ◽  
Leigh Harmon ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Multiple Genes ◽  
Clinical Description

Relationship of Major Histocompatibility Complex Class II Genes to Inhibitor Antibody Formation in Hemophilia A

1990 ◽  
Vol 64 (04) ◽  
pp. 564-568 ◽  
Author(s):  
Lloyd E Lippert ◽  
Lyman Mc A Fisher ◽  
Lawrence B Schook
Keyword(s):  
Major Histocompatibility Complex ◽  
Factor Viii ◽  
Antibody Formation ◽  
Rflp Analysis ◽  
Class Ii ◽  
Major Histocompatibility ◽  
Odds Ratios ◽  
Inhibitory Antibody ◽  
Histocompatibility Complex ◽  
Hla Dr

SummaryApproximately 14% of transfused hemophiliacs develop an anti-factor VIII inhibitory antibody which specifically neutralizes factor VIII procoagulant activity. In this study an association of the major histocompatibility complex (MHC) with inhibitor antibody formation was evaluated by restriction fragment length polymorphism (RFLP) analysis using BamHI, EcoRI, HindII, PstI, PvuII and TaqI digested genomic DNA probed with DP beta, DQ alpha, DQ beta and DR beta class II MHC gene probes. The RFLP patterns for 16 non-inhibitor and 11 inhibitor hemophiliac patients were analyzed. These 24 enzyme:probe combinations generated 231 fragments. Fifteen (15) fragments associated with the inhibitor phenotype; odds ratios ranged from 5.1 to 45 and lower bounds of 95% confidence intervals were > 1.000 for all 15 fragments. Five (5) fragments associated with non-inhibitors, with odds ratios ranging from 6.4 to 51.7. This report establishes a MHC related genetic basis for the inhibitor phenotype. No statistically significant differences in the distribution of serologically defined HLA-DR phenotypes were observed between the inhibitor and non-inhibitor groups.

Association of susceptibility to spontaneous diabetes in rat with genes of major histocompatibility complex

Diabetes ◽  
1988 ◽  
Vol 37 (10) ◽  
pp. 1438-1443 ◽  
Author(s):  
E. Colle ◽  
S. J. Ono ◽  
A. Fuks ◽  
R. D. Guttmann ◽  
T. A. Seemayer
Keyword(s):  
Major Histocompatibility Complex ◽  
Spontaneous Diabetes ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

Restriction fragment polymorphisms in the major histocompatibility complex of diabetic BB rats

Diabetes ◽  
1984 ◽  
Vol 33 (8) ◽  
pp. 807-809 ◽  
Author(s):  
W. Kastern ◽  
T. Dyrberg ◽  
J. Scholler ◽  
I. Kryspin-Sorensen
Keyword(s):  
Major Histocompatibility Complex ◽  
Restriction Fragment ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Bb Rats
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