scholarly journals Role of Plasma Vasopressin in Impaired Water Excretion of Glucocorticoid Deficiency

1978 ◽  
Vol 62 (4) ◽  
pp. 738-744 ◽  
Author(s):  
John Boykin ◽  
Antoine Detorrenté ◽  
Abby Erickson ◽  
Gary Robertson ◽  
Robert W. Schrier
1998 ◽  
Vol 24 (5) ◽  
pp. 341-347
Author(s):  
Katsuhiko Yonemura ◽  
Ryuichi Furuya ◽  
Yutaka Oki ◽  
Hideki Matsushima ◽  
Kazuhisa Ohishi ◽  
...  

1980 ◽  
Vol 18 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Stuart L. Linas ◽  
Tomas Berl ◽  
Gary L. Robertson ◽  
Gary A. Aisenbrey ◽  
Robert W. Schrier ◽  
...  

2000 ◽  
Vol 279 (3) ◽  
pp. F502-F508 ◽  
Author(s):  
Takako Saito ◽  
San-E Ishikawa ◽  
Fumiko Ando ◽  
Minori Higashiyama ◽  
Shoichiro Nagasaka ◽  
...  

We determined alterations in renal aquaporin-2 (AQP2) gene expression in association with impaired water excretion in glucocorticoid-deficient rats. After adrenalectomy, Sprague-Dawley rats were administered aldosterone alone by osmotic pumps (glucocorticoid-deficient rats). As a control, both aldosterone and dexamethasone were administered. These animals were subjected to the studies on days 7–14. The expressions of AQP2 mRNA and protein in kidney of the glucocorticoid-deficient rats were increased by 1.6- and 1.4-fold compared with the control rats, respectively. An acute oral water load test verified the marked impairment in water excretion in the glucocorticoid-deficient rats. One hour after the water load, the expressions of AQP2 mRNA and protein were significantly reduced in the control rats, but they remained unchanged in the glucocorticoid-deficient rats. However, there was no alteration in [3H]arginine vasopressin (AVP) receptor binding and AVP V2 receptor mRNA expression in the glucocorticoid-deficient rats. A V2-receptor antagonist abolished the increased expressions of AQP2 mRNA and protein in the glucocorticoid-deficient rats. These results indicate that augmented expression of AQP2 participates in impaired water excretion, dependent on AVP, in glucocorticoid deficiency.


1978 ◽  
Vol 64 (4) ◽  
pp. 613-621 ◽  
Author(s):  
W.Ronald Skowsky ◽  
Thomas A. Kikuchi

2004 ◽  
Vol 16 (4) ◽  
pp. 293-296 ◽  
Author(s):  
S. Ishikawa ◽  
T. Saito ◽  
K. Kasono

1984 ◽  
Vol 25 (2) ◽  
pp. 422-429 ◽  
Author(s):  
Mario Usberti ◽  
Stefano Federico ◽  
Sergio Meccariello ◽  
Bruno Cianciaruso ◽  
Mario Balletta ◽  
...  

Cephalalgia ◽  
1991 ◽  
Vol 11 (6) ◽  
pp. 249-250 ◽  
Author(s):  
KK Hampton ◽  
A Esack ◽  
RC Peatfield ◽  
PJ Grant

Vasopressin is a vasoactive hormone secreted from the posterior pituitary. At low concentration its role is in regulating renal water excretion, but at higher concentrations it has a number of extrarenal actions, including effects on blood flow. To investigate the role of vasopressin in spontaneous migraine, paired samples were collected from 14 subjects (a) during an acute attack of spontaneous migraine, and (b) when symptom-free for at least seven days. During an attack, vasopressin was consistently raised (median (range) 3.5 (1.2–9.6) pg/ml v 0.5 (0.5–1.1) pg/ml, p < 0.001). The highest vasopressin concentration occurred in the only patient who vomited. The results suggest vasopressin rises during an attack of spontaneous migraine, and this may, in part, be related to emesis. In the majority, vasopressin levels only rose sufficiently to have some renal antidiuretic effect, although in some these levels could have been sufficient to cause alteration in peripheral blood flow. Release of vasopressin may be responsible for the facial pallor and antidiuresis observed in migraine.


1981 ◽  
Vol 20 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Stuart L. Linas ◽  
Robert J. Anderson ◽  
Stephen J. Guggenheim ◽  
Gary L. Robertson ◽  
Tomas Berl ◽  
...  

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