scholarly journals Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes.

1975 ◽  
Vol 56 (6) ◽  
pp. 1499-1508 ◽  
Author(s):  
J M Olefsky
1982 ◽  
Vol 4 (4) ◽  
pp. 261-271 ◽  
Author(s):  
Tj. Wieringa ◽  
G. Bruin ◽  
W. P. M. Meerwijk ◽  
H. M. J. Krans

1992 ◽  
Vol 70 (8) ◽  
pp. 1190-1194 ◽  
Author(s):  
Nirmal S. Basi ◽  
K. G. Thomaskutty ◽  
Richard H. Pointer

When isolated rat adipocytes were incubated with increasing concentrations of levamisole (0.5–5 mM), basal glucose oxidation decreased by almost 50% and insulin-stimulated glucose oxidation decreased by 90%. The decrease in glucose oxidation correlated with an inhibition of glucose transport, since levamisole at 5.0 mM decreased basal 3-O-methylglucose transport by 60% and insulin-stimulated transport by 80%. Diamide-stimulated glucose transport was also inhibited approximately 80% by 5.0 mM levamisole. Levamisole at concentrations up to 5.0 mM had no effect on phosphofructokinase activity. The present results suggest that levamisole inhibits glucose utilization by inhibiting glucose transport in a concentration-dependent manner.Key words: insulin, levamisole, glucose transport, adipocytes.


1982 ◽  
Vol 14 (4) ◽  
pp. 261-271
Author(s):  
Tj. Wieringa ◽  
G. de Bruin ◽  
W. P. M. van Meerwijk ◽  
H. M. J. Krans

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