scholarly journals Impaired Lymphocyte Transformation in Hodgkin's Disease. EVIDENCE FOR DEPLETION OF CIRCULATING T-LYMPHOCYTES

1973 ◽  
Vol 52 (8) ◽  
pp. 1908-1917 ◽  
Author(s):  
Kenneth M. Matchett ◽  
Andrew T. Huang ◽  
William B. Kremer
Keyword(s):  
T Lymphocytes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Lymphocyte Transformation

Tissue T-lymphocytes in untreated Hodgkin's disease morphologic and functional correlations in spleens and lymph nodes

Cancer ◽  
1982 ◽  
Vol 50 (2) ◽  
pp. 259-268 ◽  
Author(s):  
Carlo D. Baroni ◽  
Luigi Ruco ◽  
Stefania Uccini ◽  
Antonio Foschi ◽  
Massimo Occhionero ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Lymph Nodes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease

scholarly journals T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28

Blood ◽  
1996 ◽  
Vol 88 (1) ◽  
pp. 236-241 ◽  
Author(s):  
C Renner ◽  
S Ohnesorge ◽  
G Held ◽  
S Bauer ◽  
W Jung ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
T Cell Receptor ◽  
Hodgkin's Disease ◽  
Tumor Antigens ◽  
Hodgkin’S Disease ◽  
Cell Receptor ◽  
Novel Approach ◽  
Zeta Chain

To investigate the mechanisms underlying the deficiency of T lymphocytes from patients with Hodgkin's disease, we investigated the expression of the T-cell receptor (TCR) zeta chain in patients with Hodgkin's disease. By flow cytometry using an anti-zeta chain monoclonal antibody, peripheral blood T lymphocytes from patients with untreated Hodgkin's disease were shown to express decreased levels of the TCR zeta chain. After stimulation by combined CD3 and CD28 cross- linking, T cells from Hodgkin's disease patients upregulated zeta chain protein expression to normal values within 48 hours and achieved a cytolytic potential and levels of interleukin (IL)-2 secretion that were not different from T cells obtained from healthy controls. These results show that downregulation of the TCR zeta chain in Hodgkin's T lymphocytes is a reversible event. Costimulation of CD3 and CD28 is a novel approach for overcoming the T-cell deficiency in Hodgkin's disease and might be exploited clinically. As upregulation of the zeta chain can also be achieved using bispecific monoclonal antibodies (BI- MoAbs) with specificity for tumor antigens and CD3 and CD28, respectively, an immunotherapy with CD3/CD30 and CD28/CD30 Bi-MoAbs may overcome and should therefore, not be jeopardized by the inherent T- cell deficiency in patients with Hodgkin's disease.

scholarly journals L428 cells derived from Hodgkin's disease produce E rosette-inhibiting factor

Blood ◽  
1990 ◽  
Vol 76 (4) ◽  
pp. 791-796 ◽  
Author(s):  
I Katay ◽  
U Wirnitzer ◽  
H Burrichter ◽  
C von Kalle ◽  
E Schell-Frederick ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cell Line ◽  
T Lymphocyte ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Target Cells ◽  
Normal Peripheral Blood ◽  
Inhibiting Factor ◽  
C 30

Abstract Diminished rosetting capacity of T cells is a well-known phenomenon in Hodgkin's disease, and inhibitors of E rosette formation have been reported to be present in the plasma of patients with Hodgkin's disease. The cell line L428, representing an in vitro counterpart of Hodgkin and Sternberg-Reed cells, could be shown to release a factor capable of suppressing the binding of sheep red blood cells (SRBC) to normal peripheral-blood T lymphocytes or to a T-cell line (L735). At maximally effective concentrations, RIF (rosette inhibiting factor) inhibited T lymphocyte rosetting by approximately 40% (mean from 184 healthy controls). The diminished E rosetting of T lymphocytes from Hodgkin's patients was not further suppressed by added RIF. This factor inhibited binding of SRBC to their target cells at 37 degrees C but not at 4 degrees C. The factor could be stored lyophilized at -20 degrees C and was stable at 56 degrees C (30 minutes). RIF was inactive below pH 6 and above pH 9 or after trypsin digestion. Purification by affinity, ion exchange, and molecular sieve chromatography showed activity peaks at 12.5 Kd, 25 Kd, 50 Kd, and 100 Kd.

Functional Activities of Enriched Fc Receptor Bearing T Lymphocytes in Hodgkin’s Disease

Oncology ◽  
1986 ◽  
Vol 43 (3) ◽  
pp. 159-164 ◽  
Author(s):  
Beena N. Gulwani ◽  
S.H. Advani ◽  
Sudha G. Gangal
Keyword(s):  
T Lymphocytes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Fc Receptor ◽  
Functional Activities

Increased T lymphocytes and IgMEA-receptor lymphocytes in Hodgkin's disease spleens

1977 ◽  
Vol 31 (2) ◽  
pp. 193-198 ◽  
Author(s):  
C.P. Hunter ◽  
G. Pinkus ◽  
L. Woodward ◽  
W.C. Moloney ◽  
W.H. Churchill
Keyword(s):  
T Lymphocytes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease
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