Functional Activities of Enriched Fc Receptor Bearing T Lymphocytes in Hodgkin’s Disease

Oncology ◽  
1986 ◽  
Vol 43 (3) ◽  
pp. 159-164 ◽  
Author(s):  
Beena N. Gulwani ◽  
S.H. Advani ◽  
Sudha G. Gangal
Keyword(s):  
T Lymphocytes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Fc Receptor ◽  
Functional Activities

Tissue T-lymphocytes in untreated Hodgkin's disease morphologic and functional correlations in spleens and lymph nodes

Cancer ◽  
1982 ◽  
Vol 50 (2) ◽  
pp. 259-268 ◽  
Author(s):  
Carlo D. Baroni ◽  
Luigi Ruco ◽  
Stefania Uccini ◽  
Antonio Foschi ◽  
Massimo Occhionero ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Lymph Nodes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease

scholarly journals T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28

Blood ◽  
1996 ◽  
Vol 88 (1) ◽  
pp. 236-241 ◽  
Author(s):  
C Renner ◽  
S Ohnesorge ◽  
G Held ◽  
S Bauer ◽  
W Jung ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
T Cell Receptor ◽  
Hodgkin's Disease ◽  
Tumor Antigens ◽  
Hodgkin’S Disease ◽  
Cell Receptor ◽  
Novel Approach ◽  
Zeta Chain

To investigate the mechanisms underlying the deficiency of T lymphocytes from patients with Hodgkin's disease, we investigated the expression of the T-cell receptor (TCR) zeta chain in patients with Hodgkin's disease. By flow cytometry using an anti-zeta chain monoclonal antibody, peripheral blood T lymphocytes from patients with untreated Hodgkin's disease were shown to express decreased levels of the TCR zeta chain. After stimulation by combined CD3 and CD28 cross- linking, T cells from Hodgkin's disease patients upregulated zeta chain protein expression to normal values within 48 hours and achieved a cytolytic potential and levels of interleukin (IL)-2 secretion that were not different from T cells obtained from healthy controls. These results show that downregulation of the TCR zeta chain in Hodgkin's T lymphocytes is a reversible event. Costimulation of CD3 and CD28 is a novel approach for overcoming the T-cell deficiency in Hodgkin's disease and might be exploited clinically. As upregulation of the zeta chain can also be achieved using bispecific monoclonal antibodies (BI- MoAbs) with specificity for tumor antigens and CD3 and CD28, respectively, an immunotherapy with CD3/CD30 and CD28/CD30 Bi-MoAbs may overcome and should therefore, not be jeopardized by the inherent T- cell deficiency in patients with Hodgkin's disease.

scholarly journals L428 cells derived from Hodgkin's disease produce E rosette-inhibiting factor

Blood ◽  
1990 ◽  
Vol 76 (4) ◽  
pp. 791-796 ◽  
Author(s):  
I Katay ◽  
U Wirnitzer ◽  
H Burrichter ◽  
C von Kalle ◽  
E Schell-Frederick ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cell Line ◽  
T Lymphocyte ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Target Cells ◽  
Normal Peripheral Blood ◽  
Inhibiting Factor ◽  
C 30

Abstract Diminished rosetting capacity of T cells is a well-known phenomenon in Hodgkin's disease, and inhibitors of E rosette formation have been reported to be present in the plasma of patients with Hodgkin's disease. The cell line L428, representing an in vitro counterpart of Hodgkin and Sternberg-Reed cells, could be shown to release a factor capable of suppressing the binding of sheep red blood cells (SRBC) to normal peripheral-blood T lymphocytes or to a T-cell line (L735). At maximally effective concentrations, RIF (rosette inhibiting factor) inhibited T lymphocyte rosetting by approximately 40% (mean from 184 healthy controls). The diminished E rosetting of T lymphocytes from Hodgkin's patients was not further suppressed by added RIF. This factor inhibited binding of SRBC to their target cells at 37 degrees C but not at 4 degrees C. The factor could be stored lyophilized at -20 degrees C and was stable at 56 degrees C (30 minutes). RIF was inactive below pH 6 and above pH 9 or after trypsin digestion. Purification by affinity, ion exchange, and molecular sieve chromatography showed activity peaks at 12.5 Kd, 25 Kd, 50 Kd, and 100 Kd.

Increased T lymphocytes and IgMEA-receptor lymphocytes in Hodgkin's disease spleens

1977 ◽  
Vol 31 (2) ◽  
pp. 193-198 ◽  
Author(s):  
C.P. Hunter ◽  
G. Pinkus ◽  
L. Woodward ◽  
W.C. Moloney ◽  
W.H. Churchill
Keyword(s):  
T Lymphocytes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease

Decreased membrane “fluidity” of T lymphocytes from untreated patients with Hodgkin's disease

1986 ◽  
Vol 10 (12) ◽  
pp. 1477-1484 ◽  
Author(s):  
Alexandre Aleksijevic ◽  
Gérard Cremel ◽  
Christine Mutet ◽  
Cathy Giron ◽  
Pierre Hubert ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Membrane Fluidity ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease
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