scholarly journals Evidence for suppression of parathyroid gland activity by hypermagnesemia

1970 ◽  
Vol 49 (9) ◽  
pp. 1619-1629 ◽  
Author(s):  
Shaul G. Massry ◽  
Jack W. Coburn ◽  
Charles R. Kleeman
2004 ◽  
Vol 44 (3) ◽  
pp. 476-480 ◽  
Author(s):  
Jose-Vicente Torregrosa ◽  
David Fuster ◽  
Juan Ybarra ◽  
Jaime Ortín ◽  
Agustín Moreno ◽  
...  

1972 ◽  
Vol 355 (4) ◽  
pp. 297-308 ◽  
Author(s):  
E. Alten�hr ◽  
F. Leonhardt

1981 ◽  
Vol 111 (3) ◽  
pp. 514-524 ◽  
Author(s):  
Joellen Welsh ◽  
Ruth Schwartz ◽  
Lennart Krook

Author(s):  
S.K. Aggarwal ◽  
J.M. Fadool

Cisplatin (CDDP) a potent antitumor agent suffers from severe toxic side effects with nephrotoxicity being the major dose-limiting factor, The primary mechanism of its action has been proposed to be through its cross-linking DNA strands. It has also been shown to inactivate various transport enzymes and induce hypocalcemia and hypomagnesemia that may be the underlying cause for some of its toxicities. The present is an effort to study its influence on the parathyroid gland for any hormonal changes that control calcium levels in the body.Male Swiss Wistar rats (Crl: (WI) BR) weighing 200-300 g and of 60 days in age were injected (ip) with cisplatin (7mg/kg in normal saline). The controls received saline injections only. The animals were injected (iv) with calcium (0.5 ml of 10% calcium gluconate/day) and were killed by decapitation on day 1 through 5. Trunk blood was collected in heparinized tubes.


Sign in / Sign up

Export Citation Format

Share Document