scholarly journals Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

2000 ◽  
Vol 106 (12) ◽  
pp. 1489-1499 ◽  
Author(s):  
Masayoshi Shibata ◽  
Shinya Yamada ◽  
S. Ram Kumar ◽  
Miguel Calero ◽  
James Bading ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Ldl Receptor ◽  
Brain Barrier ◽  
Related Protein ◽  
Blood Brain

scholarly journals Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor–related protein

2003 ◽  
Vol 112 (10) ◽  
pp. 1533-1540 ◽  
Author(s):  
Manuel Yepes ◽  
Maria Sandkvist ◽  
Elizabeth G. Moore ◽  
Thomas H. Bugge ◽  
Dudley K. Strickland ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Blood Brain Barrier ◽  
Ldl Receptor ◽  
Brain Barrier ◽  
Tissue Type ◽  
Related Protein ◽  
Tissue Type Plasminogen Activator ◽  
Blood Brain ◽  
Type Plasminogen Activator

A New Function for the LDL Receptor: Transcytosis of LDL Through the Blood-Brain Barrier

1996 ◽  
pp. 254-254 ◽  
Author(s):  
Bénédicte Dehouck ◽  
Marie-Pierre Dehouck ◽  
Jean-Charles Fruchart ◽  
Roméo Cecchelli
Keyword(s):  
Blood Brain Barrier ◽  
Ldl Receptor ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Billel Benmimoun ◽  
Florentia Papastefanaki ◽  
Bruno Périchon ◽  
Katerina Segklia ◽  
Nicolas Roby ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Ldl Receptor ◽  
Systemic Infection ◽  
Brain Barrier ◽  
Infection Model ◽  
Brain Infection ◽  
Blood Brain ◽  
Group B

AbstractPathogens able to cross the blood-brain barrier (BBB) induce long-term neurological sequelae and death. Understanding how neurotropic pathogens bypass this strong physiological barrier is a prerequisite to devise therapeutic strategies. Here we propose an innovative model of infection in the developing Drosophila brain, combining whole brain explants with in vivo systemic infection. We find that several mammalian pathogens are able to cross the Drosophila BBB, including Group B Streptococcus (GBS). Amongst GBS surface components, lipoproteins, and in particular the B leucine-rich Blr, are important for BBB crossing and virulence in Drosophila. Further, we identify (V)LDL receptor LpR2, expressed in the BBB, as a host receptor for Blr, allowing GBS translocation through endocytosis. Finally, we show that Blr is required for BBB crossing and pathogenicity in a murine model of infection. Our results demonstrate the potential of Drosophila for studying BBB crossing by pathogens and identify a new mechanism by which pathogens exploit the machinery of host barriers to generate brain infection.

scholarly journals Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Marko Brankatschk ◽  
Sebastian Dunst ◽  
Linda Nemetschke ◽  
Suzanne Eaton
Keyword(s):  
Blood Brain Barrier ◽  
Insulin Signaling ◽  
Ldl Receptor ◽  
Dietary Lipid ◽  
Brain Barrier ◽  
Free Calcium ◽  
Blood Brain ◽  
Nutritional Conditions ◽  
Drosophila Brain ◽  
Related Proteins

The Insulin signaling pathway couples growth, development and lifespan to nutritional conditions. Here, we demonstrate a function for the Drosophila lipoprotein LTP in conveying information about dietary lipid composition to the brain to regulate Insulin signaling. When yeast lipids are present in the diet, free calcium levels rise in Blood Brain Barrier glial cells. This induces transport of LTP across the Blood Brain Barrier by two LDL receptor-related proteins: LRP1 and Megalin. LTP accumulates on specific neurons that connect to cells that produce Insulin-like peptides, and induces their release into the circulation. This increases systemic Insulin signaling and the rate of larval development on yeast-containing food compared with a plant-based food of similar nutritional content.

scholarly journals The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increasesin vitrodrug delivery across blood-brain barrier cells

2012 ◽  
Vol 167 (7) ◽  
pp. 1431-1447 ◽  
Author(s):  
ML Pinzón-Daza ◽  
R Garzón ◽  
PO Couraud ◽  
IA Romero ◽  
B Weksler ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Ldl Receptor ◽  
Brain Barrier ◽  
Blood Brain

Agouti-related protein(83-132) aggregates and crosses the blood-brain barrier slowly

Metabolism ◽  
2000 ◽  
Vol 49 (11) ◽  
pp. 1444-1448 ◽  
Author(s):  
Abba J Kastin ◽  
Victoria Akerstrom ◽  
Laszlo Hackler
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Related Protein ◽  
Blood Brain ◽  
Agouti Related Protein

scholarly journals A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier

1997 ◽  
Vol 138 (4) ◽  
pp. 877-889 ◽  
Author(s):  
Bénédicte Dehouck ◽  
Laurence Fenart ◽  
Marie-Pierre Dehouck ◽  
Annick Pierce ◽  
Gérard Torpier ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Cytoplasmic Domain ◽  
Brain Barrier ◽  
Classical Pathway ◽  
Brain Capillary ◽  
Blood Brain ◽  
The Brain

Lipoprotein transport across the blood–brain barrier (BBB) is of critical importance for the delivery of essential lipids to the brain cells. The occurrence of a low density lipoprotein (LDL) receptor on the BBB has recently been demonstrated. To examine further the function of this receptor, we have shown using an in vitro model of the BBB, that in contrast to acetylated LDL, which does not cross the BBB, LDL is specifically transcytosed across the monolayer. The C7 monoclonal antibody, known to interact with the LDL receptor-binding domain, totally blocked the transcytosis of LDL, suggesting that the transcytosis is mediated by the receptor. Furthermore, we have shown that cholesterol-depleted astrocytes upregulate the expression of the LDL receptor at the BBB. Under these conditions, we observed that the LDL transcytosis parallels the increase in the LDL receptor, indicating once more that the LDL is transcytosed by a receptor-mediated mechanism. The nondegradation of the LDL during the transcytosis indicates that the transcytotic pathway in brain capillary endothelial cells is different from the LDL receptor classical pathway. The switch between a recycling receptor to a transcytotic receptor cannot be explained by a modification of the internalization signals of the cytoplasmic domain of the receptor, since we have shown that LDL receptor messengers in growing brain capillary ECs (recycling LDL receptor) or differentiated cells (transcytotic receptor) are 100% identical, but we cannot exclude posttranslational modifications of the cytoplasmic domain, as demonstrated for the polymeric immunoglobulin receptor. Preliminary studies suggest that caveolae are likely to be involved in the potential transport of LDL from the blood to the brain.

scholarly journals An original model of brain infection identifies the hijacking of host lipoprotein import as a bacterial strategy for blood-brain barrier crossing

2020 ◽  
Author(s):  
Billel Benmimoun ◽  
Florentia Papastefanaki ◽  
Bruno Périchon ◽  
Katerina Segklia ◽  
Nicolas Roby ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Group B Streptococcus ◽  
Ldl Receptor ◽  
Systemic Infection ◽  
Brain Barrier ◽  
Brain Infection ◽  
Blood Brain ◽  
Drosophila Brain ◽  
Group B

AbstractPathogens able to cross the blood-brain barrier (BBB) induce long-term neurological sequelae and death. Understanding how neurotropic pathogens bypass this strong physiological barrier is a prerequisite to devise therapeutic strategies. Here we propose an innovative model of infection in the developing Drosophila brain, combining whole brain explants with in vivo systemic infection. We identified several mammalian pathogens able to cross the Drosophila BBB, including Group B Streptococcus (GBS). Amongst GBS surface components, lipoproteins, and in particular the B leucin-rich Blr, were important for BBB crossing and virulence in Drosophila. Further, we identified (V)LDL receptor LpR2, expressed in the BBB, as a host receptor for Blr, allowing GBS translocation through endocytosis. Finally, we demonstrated that Blr is required for BBB crossing and pathogenicity in a murine model of infection. Our results support the relevance of Drosophila for studying host-pathogen interactions and identify a new mechanism by which pathogens exploit host barriers to generate brain infection.

scholarly journals Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Bereketeab Haileselassie ◽  
Amit U. Joshi ◽  
Paras S. Minhas ◽  
Riddhita Mukherjee ◽  
Katrin I. Andreasson ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Related Protein ◽  
Septic Encephalopathy ◽  
Blood Brain
Sign in / Sign up

Export Citation Format

Share Document