Agouti-related protein(83-132) aggregates and crosses the blood-brain barrier slowly

Metabolism ◽  
2000 ◽  
Vol 49 (11) ◽  
pp. 1444-1448 ◽  
Author(s):  
Abba J Kastin ◽  
Victoria Akerstrom ◽  
Laszlo Hackler
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Related Protein ◽  
Blood Brain ◽  
Agouti Related Protein

scholarly journals Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor–related protein

2003 ◽  
Vol 112 (10) ◽  
pp. 1533-1540 ◽  
Author(s):  
Manuel Yepes ◽  
Maria Sandkvist ◽  
Elizabeth G. Moore ◽  
Thomas H. Bugge ◽  
Dudley K. Strickland ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Blood Brain Barrier ◽  
Ldl Receptor ◽  
Brain Barrier ◽  
Tissue Type ◽  
Related Protein ◽  
Tissue Type Plasminogen Activator ◽  
Blood Brain ◽  
Type Plasminogen Activator

scholarly journals Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

2000 ◽  
Vol 106 (12) ◽  
pp. 1489-1499 ◽  
Author(s):  
Masayoshi Shibata ◽  
Shinya Yamada ◽  
S. Ram Kumar ◽  
Miguel Calero ◽  
James Bading ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Ldl Receptor ◽  
Brain Barrier ◽  
Related Protein ◽  
Blood Brain

scholarly journals Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Bereketeab Haileselassie ◽  
Amit U. Joshi ◽  
Paras S. Minhas ◽  
Riddhita Mukherjee ◽  
Katrin I. Andreasson ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Related Protein ◽  
Septic Encephalopathy ◽  
Blood Brain

scholarly journals Astragaloside IV Reduces Cerebral Ischemia/Reperfusion-Induced Blood-Brain Barrier Permeability in Rats by Inhibiting ER Stress-Mediated Apoptosis

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Bonan Hou ◽  
Rui Liu ◽  
You Wu ◽  
Shuiqing Huang
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Western Blot ◽  
Blood Brain Barrier ◽  
Ischemia Reperfusion ◽  
Brain Barrier ◽  
Related Protein ◽  
Astragaloside Iv ◽  
Protein Levels ◽  
Blood Brain

Background. Previous studies proved that AS-IV could prevent blood-brain barrier (BBB) against an increase in permeability. However, its underlying molecular mechanism has not been enlightened yet. The aim of the study is to reveal the potential protective mechanism of astragaloside IV (AS-IV) on the blood-brain barrier after ischemia-reperfusion. Methods. In vivo, AS-IV neurological protection was measured by Long’s five-point scale and 2,3,5-triphenyltetrazolium chloride staining. AS-IV protection for BBB was observed by Evans blue extravasation technique. Endoplasmic reticulum stress and apoptosis-related protein levels were measured by western blot with AS-IV intervention. In vitro, cell apoptosis was analyzed by western blot and flow cytometry.Endoplasmic reticulum stress-related protein levels were quantified through western blot. Results. AS-IV treatment could decrease the infarct size in rats’ brain and protect the BBB against Evans blue permeating through brain, after ischemia/reperfusion, significantly. Further, ischemia/reperfusion or oxygen‐glucose deprivation/reperfusion was found to have an increase in endothelial cell apoptosis proteins, such as Bax, Bcl-2, and caspase-3, and endoplasmic reticulum stress-associated proteins, such as phosphorylated PERK and eIF2α, Bip, and CHOP, which were attenuated by AS-IV treatment. Conclusions. AS-IV can effectively protect the blood-brain barrier and reduce the area of cerebral infarction via inhibiting endoplasmic reticulum stress-mediated apoptosis in endothelial cells.

Conformationally Constrained Peptide Drugs Targeted at the Blood-Brain Barrier

1995 ◽  
Author(s):  
Thomas P. Davis ◽  
Thomas J. Abbruscato ◽  
Elizabeth Brownson ◽  
Victor J. Hruby
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Peptide Drugs ◽  
Conformationally Constrained ◽  
Blood Brain
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