scholarly journals Rodent Hyperglycemia-Induced Inner Retinal Deficits are Mirrored in Human Diabetes

2014 ◽  
Vol 3 (3) ◽  
pp. 6 ◽  
Author(s):  
Machelle T. Pardue ◽  
Claire S. Barnes ◽  
Moon K. Kim ◽  
Moe H. Aung ◽  
Raj Amarnath ◽  
...  
Keyword(s):  
Human Diabetes

Leptin in serum and vitreous humor, and retinal ob mRNA, in human diabetes

2013 ◽  
pp. 1-1
Author(s):  
A Syed Imran ◽  
A Diane Wilkinson ◽  
Y Alex Tan ◽  
D John Dickinson ◽  
M Dan O'Brien ◽  
...  
Keyword(s):  
Vitreous Humor ◽  
Human Diabetes

scholarly journals An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jinyoung Kim ◽  
Kihyoun Park ◽  
Min Jung Kim ◽  
Hyejin Lim ◽  
Kook Hwan Kim ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Function ◽  
Therapeutic Potential ◽  
Therapeutic Modality ◽  
Protective Effects ◽  
Β Cells ◽  
Β Cell ◽  
Islet Amyloid ◽  
Amyloid Accumulation ◽  
Human Diabetes

AbstractWe have reported that autophagy is crucial for clearance of amyloidogenic human IAPP (hIAPP) oligomer, suggesting that an autophagy enhancer could be a therapeutic modality against human diabetes with amyloid accumulation. Here, we show that a recently identified autophagy enhancer (MSL-7) reduces hIAPP oligomer accumulation in human induced pluripotent stem cell-derived β-cells (hiPSC-β-cells) and diminishes oligomer-mediated apoptosis of β-cells. Protective effects of MSL-7 against hIAPP oligomer accumulation and hIAPP oligomer-mediated β-cell death are significantly reduced in cells with knockout of MiTF/TFE family members such as Tfeb or Tfe3. MSL-7 improves glucose tolerance and β-cell function of hIAPP+ mice on high-fat diet, accompanied by reduced hIAPP oligomer/amyloid accumulation and β-cell apoptosis. Protective effects of MSL-7 against hIAPP oligomer-mediated β-cell death and the development of diabetes are also significantly reduced by β-cell-specific knockout of Tfeb. These results suggest that an autophagy enhancer could have therapeutic potential against human diabetes characterized by islet amyloid accumulation.

scholarly journals Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

Circulation ◽  
2002 ◽  
Vol 105 (14) ◽  
pp. 1656-1662 ◽  
Author(s):  
Tomasz J. Guzik ◽  
Shafi Mussa ◽  
Daniela Gastaldi ◽  
Jerzy Sadowski ◽  
Chandi Ratnatunga ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Superoxide Production ◽  
Human Diabetes

Lipid-Derived Modifications of Plasma Proteins in Experimental and Human Diabetes

2005 ◽  
Vol 1043 (1) ◽  
pp. 404-412 ◽  
Author(s):  
ANDRZEJ S. JANUSZEWSKI ◽  
ALICIA J. JENKINS ◽  
JOHN W. BAYNES ◽  
SUZANNE R. THORPE
Keyword(s):  
Plasma Proteins ◽  
Human Diabetes

Epidemiology of Urolithiasis and Calcium Metabolism in Human Diabetes Mellitus

1985 ◽  
pp. 47-50 ◽  
Author(s):  
W. Tschöpe ◽  
E. Ritz ◽  
M. Haslbeck ◽  
H. Mehnert ◽  
D. Deppermann
Keyword(s):  
Diabetes Mellitus ◽  
Calcium Metabolism ◽  
Human Diabetes

Haversian bone formation rates determined by a new method in a mastodon, and in human diabetes mellitus and osteoporosis

1970 ◽  
Vol 6 (1) ◽  
pp. 204-219 ◽  
Author(s):  
K. Wu ◽  
K. E. Schubeck ◽  
H. M. Frost ◽  
A. Villanueva
Keyword(s):  
Diabetes Mellitus ◽  
Bone Formation ◽  
New Method ◽  
Human Diabetes
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