scholarly journals Neuroprotection of the Inner Retina Also Prevents Secondary Outer Retinal Pathology in a Mouse Model of Glaucoma

2021 ◽  
Vol 62 (9) ◽  
pp. 35
Author(s):  
Sandeep Kumar ◽  
Hariharasubramanian Ramakrishnan ◽  
Suresh Viswanathan ◽  
Abram Akopian ◽  
Stewart A. Bloomfield
Keyword(s):  
Mouse Model ◽  
Inner Retina ◽  
Retinal Pathology

scholarly journals A Role for Vascular Deficiency in Retinal Pathology in a Mouse Model of Ataxia-Telangiectasia

2011 ◽  
Vol 179 (3) ◽  
pp. 1533-1541 ◽  
Author(s):  
Dorit Raz-Prag ◽  
Ronit Galron ◽  
Niva Segev-Amzaleg ◽  
Arieh S. Solomon ◽  
Yosef Shiloh ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ataxia Telangiectasia ◽  
Retinal Pathology

scholarly journals A lasered mouse model of retinal degeneration displays progressive outer retinal pathology providing insights into early geographic atrophy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Paul Ibbett ◽  
Srinivas V. Goverdhan ◽  
Elena Pipi ◽  
Joe K. Chouhan ◽  
Eloise Keeling ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinal Degeneration ◽  
Geographic Atrophy ◽  
Retinal Pathology

scholarly journals Gene Therapy Targeting the Inner Retina Rescues the Retinal Phenotype in a Mouse Model of CLN3 Batten Disease

2020 ◽  
Vol 31 (13-14) ◽  
pp. 709-718 ◽  
Author(s):  
Sophia-Martha kleine Holthaus ◽  
Mikel Aristorena ◽  
Ryea Maswood ◽  
Olha Semenyuk ◽  
Justin Hoke ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Batten Disease ◽  
Inner Retina

Viability of the inner retina in a novel mouse model of retinitis pigmentosa

2010 ◽  
Author(s):  
Emily E O'Brien ◽  
Erica L Fletcher ◽  
Hamish Meffin ◽  
Anthony N Burkitt ◽  
David B Grayden ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinitis Pigmentosa ◽  
Inner Retina

scholarly journals Inner Retina Remodeling in a Mouse Model of Stargardt-like Macular Dystrophy (STGD3)

2010 ◽  
Vol 51 (4) ◽  
pp. 2248 ◽  
Author(s):  
Sharee Kuny ◽  
Frédéric Gaillard ◽  
Silvina C. Mema ◽  
Paul R. Freund ◽  
Kang Zhang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Macular Dystrophy ◽  
Inner Retina

scholarly journals Characterizing the Retinal Phenotype of the Thy1-h[A30P]α-syn Mouse Model of Parkinson’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Lien Veys ◽  
Joyce Devroye ◽  
Evy Lefevere ◽  
Lien Cools ◽  
Marjan Vandenabeele ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Biomarker Discovery ◽  
Ganglion Cells ◽  
Retinal Disease ◽  
Amacrine Cells ◽  
Alpha Synuclein ◽  
Molecular Alterations ◽  
Retinal Pathology

Despite decades of research, disease-modifying treatments of Parkinson’s disease (PD), the second most common neurodegenerative disease worldwide, remain out of reach. One of the reasons for this treatment gap is the incomplete understanding of how misfolded alpha-synuclein (α-syn) contributes to PD pathology. The retina, as an integral part of the central nervous system, recapitulates the PD disease processes that are typically seen in the brain, and retinal manifestations have emerged as prodromal symptoms of the disease. The timeline of PD manifestations in the visual system, however, is not fully elucidated and the underlying mechanisms are obscure. This highlights the need for new studies investigating retinal pathology, in order to propel its use as PD biomarker, and to develop validated research models to investigate PD pathogenesis. The present study pioneers in characterizing the retina of the Thy1-h[A30P]α-syn PD transgenic mouse model. We demonstrate widespread α-syn accumulation in the inner retina of these mice, of which a proportion is phosphorylated yet not aggregated. This α-syn expression coincides with inner retinal atrophy due to postsynaptic degeneration. We also reveal abnormal retinal electrophysiological responses. Absence of selective loss of melanopsin retinal ganglion cells or dopaminergic amacrine cells and inflammation indicates that the retinal manifestations in these transgenic mice diverge from their brain phenotype, and questions the specific cellular or molecular alterations that underlie retinal pathology in this PD mouse model. Nevertheless, the observed α-syn accumulation, synapse loss and functional deficits suggest that the Thy1-h[A30P]α-syn retina mimics some of the features of prodromal PD, and thus may provide a window to monitor and study the preclinical/prodromal stages of PD, PD-associated retinal disease processes, as well as aid in retinal biomarker discovery and validation.

Assessment of inner retina dysfunction and progressive ganglion cell loss in a mouse model of glaucoma

2014 ◽  
Vol 122 ◽  
pp. 40-49 ◽  
Author(s):  
María J. Pérez de Lara ◽  
Concepción Santano ◽  
Ana Guzmán-Aránguez ◽  
F. Javier Valiente-Soriano ◽  
Marcelino Avilés-Trigueros ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ganglion Cell ◽  
Cell Loss ◽  
Inner Retina

scholarly journals Investigations into Retinal Pathology in the Early Stages of a Mouse Model of Alzheimer’s Disease

2017 ◽  
Vol 56 (2) ◽  
pp. 655-675 ◽  
Author(s):  
Glyn Chidlow ◽  
John P.M. Wood ◽  
Jim Manavis ◽  
John Finnie ◽  
Robert J. Casson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Early Stages ◽  
Model Of Alzheimer’S Disease ◽  
Retinal Pathology

scholarly journals Use of Optical Coherence Tomography and Electroretinography to Evaluate Retinal Pathology in a Mouse Model of Autoimmune Uveitis

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63904 ◽  
Author(s):  
Jun Chen ◽  
Haohua Qian ◽  
Reiko Horai ◽  
Chi-Chao Chan ◽  
Rachel R. Caspi
Keyword(s):  
Optical Coherence Tomography ◽  
Mouse Model ◽  
Optical Coherence ◽  
Autoimmune Uveitis ◽  
Retinal Pathology
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