scholarly journals Macula Ganglion Cell Thickness Changes Display Location-Specific Variation Patterns in Intermediate Age-Related Macular Degeneration

2020 ◽  
Vol 61 (3) ◽  
pp. 2 ◽  
Author(s):  
Matt Trinh ◽  
Janelle Tong ◽  
Nayuta Yoshioka ◽  
Barbara Zangerl ◽  
Michael Kalloniatis ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Variation Patterns ◽  
Specific Variation ◽  
Display Location ◽  
Cell Thickness

scholarly journals Silent Information Regulator T1 in Aqueous Humor of Patients with Age-Related Macular Degeneration

2021 ◽  
Vol 15 (1) ◽  
pp. 187-195
Author(s):  
Tatsuya Mimura ◽  
Hideharu Funatsu ◽  
Hidetaka Noma ◽  
Aki Kondo ◽  
Atsushi Mizota
Keyword(s):  
Ganglion Cell ◽  
Macular Degeneration ◽  
Aqueous Humor ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Inner Nuclear Layer ◽  
Age Related Macular Degeneration ◽  
Enzyme Linked Immunosorbent Assay ◽  
Retinal Layer ◽  
Age Related

Purpose: The purpose of this study is to compare the aqueous humor level of Silent Information Regulator T1 (SIRT1) between patients with Age-related Macular Degeneration (AMD) and cataract patients. Materials and Methods: Aqueous humor level of SIRT1 was measured by enzyme-linked immunosorbent assay in 13 patients with wet-type AMD (n=13, AMD group) and 13 patients with cataracts (cataract group). In addition, the thickness of each retinal layer was determined by optical coherence tomography. Results: The aqueous humor level of SIRT1 was significantly lower in the AMD group than in the cataract group (p=0.007). In the AMD group, the SIRT1 level was positively correlated with the thickness of the retinal ganglion cell layer (r=0.31) and the inner nuclear layer (r=0.76). Conclusion: The aqueous level of SIRT1 decreased as the ganglion cell layer and inner nuclear layer became thinner, suggesting that reduction of SIRT1 activity might be involved in the pathogenesis of this disease.

Ganglion Cell Layer Thickness Change in Neovascular Age-Related Macular Degeneration Treated With Anti-VEGF Injections

2021 ◽  
pp. 247412642110403
Author(s):  
Dimosthenis Mantopoulos ◽  
Hetal Ray ◽  
George Sanchez ◽  
Russell Pokroy ◽  
Daniel B. Roth
Keyword(s):  
Ganglion Cell ◽  
Macular Degeneration ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Treated Group ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Fellow Eye ◽  
Anti Vegf ◽  
Age Related

Purpose: This work assesses bilateral ganglion cell layer–inner plexiform layer (GCL-IPL) thickness changes in patients with unilateral neovascular age-related macular degeneration (nAMD) treated with antivascular endothelial growth factor (anti-VEGF). Methods: In this single-center, retrospective, cohort study, the medical records of patients with unilateral nAMD treated with anti-VEGF were reviewed. The treated group included eyes with newly diagnosed nAMD that subsequently underwent treatment with intravitreal anti-VEGF injections. The control group was the fellow eye with dry AMD. Eyes receiving at least 10 intravitreal injections were included. Measurement of GCL-IPL thickness was performed at different time points using spectral domain–optical coherence tomography. Results: A total of 216 eyes of 108 patients met the inclusion criteria. The mean age ± SD was 80.1 ± 10.7 years. Eyes in the treated group underwent a mean ± SD of 20.2 ± 7.2 injections in 21.3 ± 6.8 months. At baseline, average mean ± SD of GCL-IPL thickness was 73.71 ± 8.81 µm and 73.84 ± 8.26 µm in the treated and fellow eye, respectively ( P = .795). After 10 injections the average thickness was 65.41 ± 14.08 µm and 68.77 ± 13.24 µm in the treated and fellow eye, respectively ( P = .007). The absolute decrease in thickness was significantly greater in the treated eye than the fellow eye (mean ± SD, 8.31 ± 11.19 µm vs 5.07 ± 10.83 µm, respectively; P = .002). Conclusions: GCL-IPL thickness decreased significantly in the treated group more than in the control group after 10 anti-VEGF injections. The mechanism and clinical significance of this observation warrants further study.

Macular Ganglion Cell Complex and Retinal Nerve Fiber Layer Comparison in Different Stages of Age-Related Macular Degeneration

2015 ◽  
Vol 160 (3) ◽  
pp. 602-607.e1 ◽  
Author(s):  
Ilaria Zucchiatti ◽  
Maurizio Battaglia Parodi ◽  
Luisa Pierro ◽  
Maria Vittoria Cicinelli ◽  
Marco Gagliardi ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Macular Degeneration ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Cell Complex ◽  
Age Related Macular Degeneration ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Age Related
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