Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation

2017 ◽  
Vol 238 (1-2) ◽  
pp. 31-43 ◽  
Author(s):  
Pedro Camacho ◽  
Marco Dutra-Medeiros ◽  
Liliana Páris
Keyword(s):  
Ganglion Cell ◽  
Macular Degeneration ◽  
Cell Complex ◽  
Age Related Macular Degeneration ◽  
Ganglion Cell Complex ◽  
Manual Segmentation ◽  
Age Related ◽  
Sd Oct

Macular Ganglion Cell Complex and Retinal Nerve Fiber Layer Comparison in Different Stages of Age-Related Macular Degeneration

2015 ◽  
Vol 160 (3) ◽  
pp. 602-607.e1 ◽  
Author(s):  
Ilaria Zucchiatti ◽  
Maurizio Battaglia Parodi ◽  
Luisa Pierro ◽  
Maria Vittoria Cicinelli ◽  
Marco Gagliardi ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Macular Degeneration ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Cell Complex ◽  
Age Related Macular Degeneration ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Age Related

scholarly journals Ganglion cell complex thickness in nonexudative age-related macular degeneration

Eye ◽  
2015 ◽  
Vol 29 (8) ◽  
pp. 1076-1080 ◽  
Author(s):  
E Yenice ◽  
A Şengün ◽  
G Soyugelen Demirok ◽  
E Turaçlı
Keyword(s):  
Ganglion Cell ◽  
Macular Degeneration ◽  
Cell Complex ◽  
Age Related Macular Degeneration ◽  
Ganglion Cell Complex ◽  
Age Related

scholarly journals Ganglion Cell Complex Evaluation in Exudative Age-Related Macular Degeneration after Repeated Intravitreal Injections of Ranibizumab

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Andrea Perdicchi ◽  
Giacomo Peluso ◽  
Daniela Iacovello ◽  
Marco Balestrieri ◽  
Martina Delle Fave ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Statistical Significance ◽  
Clinical Results ◽  
Cell Complex ◽  
Age Related Macular Degeneration ◽  
Intravitreal Injections ◽  
Ganglion Cell Complex ◽  
Intravitreal Ranibizumab ◽  
Age Related ◽  
Wet Amd

Purpose. To detect the effects of intravitreal ranibizumab injections on GCC in patients with wet AMD.Methods. 32 wet AMD eyes were selected and submitted at three ranibizumab injections. RTVue-OCT GCC and MM5 protocol were performed before treatment and twenty days after each injection.Results. At baseline mean GCC thickness was 93.9 ± 18.5 μm. Twenty days after each intravitreal injection it was, respectively, 85.8 ± 10.1, 86.5 ± 9.3, and 91.1 ± 11.5 μm, without statistical significance. A significant improvement in visual acuity (P= 0.031) and a reduction of mean foveal (P= 0.001) and macular thickness (P= 0.001) were observed.Conclusion. The clinical results confirm therapeutic efficacy of intravitreal injections of ranibizumab in wet AMD. A contemporary not statistically significant reduction of GCC thickness suggests that the loading phase of ranibizumab does not have any toxic effects on ganglion cell complex.

scholarly journals Ganglion Cell Complex Evaluation in Exudative Age-Related Macular Degeneration after Repeated Intravitreal Injections of Ranibizumab

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Andrea Perdicchi ◽  
Giacomo Peluso ◽  
Daniela Iacovello ◽  
Marco Balestrieri ◽  
Martina Delle Fave ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Statistical Significance ◽  
Clinical Results ◽  
Cell Complex ◽  
Age Related Macular Degeneration ◽  
Intravitreal Injections ◽  
Ganglion Cell Complex ◽  
Intravitreal Ranibizumab ◽  
Age Related ◽  
Wet Amd

Purpose. To detect the effects of intravitreal ranibizumab injections on GCC in patients with wet AMD.Methods. 32 wet AMD eyes were selected and submitted at three ranibizumab injections. RTVue-OCT GCC and MM5 protocol were performed before treatment and twenty days after each injection.Results. At baseline mean GCC thickness was 93.9 ± 18.5 μm. Twenty days after each intravitreal injection it was, respectively, 85.8 ± 10.1, 86.5 ± 9.3, and 91.1 ± 11.5 μm, without statistical significance. A significant improvement in visual acuity (P= 0.031) and a reduction of mean foveal (P= 0.001) and macular thickness (P= 0.001) were observed.Conclusion. The clinical results confirm therapeutic efficacy of intravitreal injections of ranibizumab in wet AMD. A contemporary not statistically significant reduction of GCC thickness suggests that the loading phase of ranibizumab does not have any toxic effects on ganglion cell complex.

scholarly journals Repeatability of Bruch’s Membrane Opening-minimum Rim Width in Age-related Macular Degeneration and Diabetic Macular Edema

2021 ◽  
Vol 62 (11) ◽  
pp. 1490-1501
Author(s):  
Bum Jun Kim ◽  
Woo Hyuk Lee ◽  
Ki Yup Nam ◽  
Ji Hye Kim ◽  
Tae Seen Kang ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Macular Edema ◽  
Optic Disc ◽  
Diabetic Macular Edema ◽  
Age Related Macular Degeneration ◽  
Disc Membrane ◽  
Rnfl Thickness ◽  
Age Related ◽  
Bruch’S Membrane Opening ◽  
Sd Oct

Purpose: To evaluate the repeatability of retinal nerve fiber layer (RNFL) thickness and Bruch’s membrane opening-minimum rim width (BMO-MRW) measurements by spectral-domain optical coherence tomography (SD-OCT) in wet age-related macular degeneration (wAMD) and diabetic macular edema (DME).Methods: This was a prospective study. The RNFL thickness and BMO-MRW parameters for each sector and global average were measured twice by SD-OCT. Repeatability was evaluated using the intraclass correlation coefficient (ICC) and coefficient of variation (CV). If the optic disc membrane was confirmed, it was analyzed by dividing it into three groups based on severity.Results: A total of 99 eyes (48 with wAMD, 51 with DME) were included in the analysis. The ICCs of the global RNFL thickness and global BMO-MRW measurements were 0.996 and 0.997, respectively, in wAMD and 0.994 and 0.996, respectively, in DME eyes. The CV values of global RNFL thickness and BMO-MRW were 0.60% and 0.73%, respectively, in wAMD eyes and 1.10% and 1.21%, respectively, in DME eyes. The disc membrane on the optic nerve head significantly affected global BMO-MRW repeatability (B = 0.814, p < 0.001).Conclusions: Both RNFL thickness and BMO-MRW measurements showed good repeatability in eyes with wAMD and DME. The severity of the optic disc membrane significantly affected the repeatability of BMO-MRW measurements in eyes with wAMD and DME. Therefore, physicians should examine the BMO-MRW in eyes with severe optic disc membrane.

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