scholarly journals Fixel-Based Analysis of Visual Pathway White Matter in Primary Open-Angle Glaucoma

2019 ◽  
Vol 60 (12) ◽  
pp. 3803 ◽  
Author(s):  
Shereif Haykal ◽  
Branislava Curcic-Blake ◽  
Nomdo M. Jansonius ◽  
Frans W. Cornelissen
Keyword(s):  
White Matter ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Pathway ◽  
Open Angle

Visual evoked potentials (VEP) studies in primary open glaucoma

2021 ◽  
Vol 19 (3) ◽  
pp. 28-31
Author(s):  
Bhagya V ◽  
Keyword(s):  
Optic Nerve ◽  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Pathway ◽  
Nerve Damage ◽  
Open Angle ◽  
Optic Nerve Damage ◽  
Visual Evoked

Background: With increasing prevalance of primary open angle glaucoma and optic nerve damage as a consequence of this, there is a need for early diagnosis and prevention of optic nerve damage. VEP, the potential recorded from the occipital region in response to the visual stimuli can be used for early detection of the primary open angle glaucoma. Visual evoked potential (VEP) is a non invasive method to assess the visual pathway. The present study was done to evaluate the impact of primary open angle glaucoma on central nervous system particularly, visual pathway. Methods: 30 primary open angle glaucoma patients attending outpatient department of ophthalmology department, SS hospital, Davanagere and 30 age matched controls selected randomly from general population were subjected to Visual evoked potential. Parameters for VEP such as latencies of waves N70, P100, and N155 peak-to-peak amplitudes of waves N70-P100 and P100-N155 were assessed and analyzed by using unpaired student-T test for comparison between cases and controls. Results: The present study observed that the there was a statistically significant increase in P100 latency in cases compared to the controls. And also there was a statistically significant decrease in N70 and P100 amplitude in cases compared to the controls. Conclusion: The present study correlates with earlier findings that visual pathway gets involved in primary open angle glaucoma even before the development of neuropathy which can be detected using VEP. Meticulous follow-up is a must to prevent the complications of primary open angle glaucoma, so that further damage can be prevented.

scholarly journals Automated Morphometry of the Visual Pathway in Primary Open-Angle Glaucoma

2011 ◽  
Vol 52 (5) ◽  
pp. 2758 ◽  
Author(s):  
Aditya T. Hernowo ◽  
Christine C. Boucard ◽  
Nomdo M. Jansonius ◽  
Johanna M. M. Hooymans ◽  
Frans W. Cornelissen
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Pathway ◽  
Open Angle ◽  
Automated Morphometry

scholarly journals Diffusional Kurtosis Imaging of White Matter Degeneration in Glaucoma

2020 ◽  
Vol 9 (10) ◽  
pp. 3122
Author(s):  
Carlo Nucci ◽  
Francesco Garaci ◽  
Simone Altobelli ◽  
Francesco Di Ciò ◽  
Alessio Martucci ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Primary Open Angle Glaucoma ◽  
Neurodegenerative Disorder ◽  
Open Angle Glaucoma ◽  
Diffusion Kurtosis Imaging ◽  
Open Angle ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri

Glaucoma is an optic neuropathy characterized by death of retinal ganglion cells and loss of their axons, progressively leading to blindness. Recently, glaucoma has been conceptualized as a more diffuse neurodegenerative disorder involving the optic nerve and also the entire brain. Consistently, previous studies have used a variety of magnetic resonance imaging (MRI) techniques and described widespread changes in the grey and white matter of patients. Diffusion kurtosis imaging (DKI) provides additional information as compared with diffusion tensor imaging (DTI), and consistently provides higher sensitivity to early microstructural white matter modification. In this study, we employ DKI to evaluate differences among healthy controls and a mixed population of primary open angle glaucoma patients ranging from stage I to V according to Hodapp–Parrish–Anderson visual field impairment classification. To this end, a cohort of patients affected by primary open angle glaucoma (n = 23) and a group of healthy volunteers (n = 15) were prospectively enrolled and underwent an ophthalmological evaluation followed by magnetic resonance imaging (MRI) using a 3T MR scanner. After estimating both DTI indices, whole-brain, voxel-wise statistical comparisons were performed in white matter using Tract-Based Spatial Statistics (TBSS). We found widespread differences in several white matter tracts in patients with glaucoma relative to controls in several metrics (mean kurtosis, kurtosis anisotropy, radial kurtosis, and fractional anisotropy) which involved localization well beyond the visual pathways, and involved cognitive, motor, face recognition, and orientation functions amongst others. Our findings lend further support to a causal brain involvement in glaucoma and offer alternative explanations for a number of multidomain impairments often observed in glaucoma patients.

Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

2020 ◽  
pp. 97-105
Author(s):  
E. N. Simakova ◽  
O. V. Stenkova
Keyword(s):  
Intraocular Pressure ◽  
Drug Therapy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Open Angle ◽  
Complex Treatment ◽  
Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

Detection of specific proteins in the aqueous humor in primary open-angle glaucoma

1990 ◽  
Vol 4 (1) ◽  
pp. 1 ◽  
Author(s):  
In Seop Lee ◽  
Young Suk Yu ◽  
Dong Myung Kim ◽  
Dong Ho Youn ◽  
Jin Q Kim
Keyword(s):  
Aqueous Humor ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Specific Proteins
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