scholarly journals Corneal Neurotization Improves Ocular Surface Health in a Novel Rat Model of Neurotrophic Keratopathy and Corneal Neurotization

2018 ◽  
Vol 59 (11) ◽  
pp. 4345 ◽  
Author(s):  
Joseph Catapano ◽  
Kira Antonyshyn ◽  
Jennifer J. Zhang ◽  
Tessa Gordon ◽  
Gregory H. Borschel
Keyword(s):  
Rat Model ◽  
Ocular Surface ◽  
Ocular Surface Health ◽  
Neurotrophic Keratopathy

Topical cis-urocanic acid prevents ocular surface irritation in both IgE -independent and -mediated rat model

2017 ◽  
Vol 255 (12) ◽  
pp. 2357-2362 ◽  
Author(s):  
Hanna-Mari Jauhonen ◽  
Jarmo Laihia ◽  
Olli Oksala ◽  
Johanna Viiri ◽  
Reijo Sironen ◽  
...  
Keyword(s):  
Rat Model ◽  
Ocular Surface ◽  
Urocanic Acid

scholarly journals Trehalose for Ocular Surface Health

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 809
Author(s):  
Jarmo Laihia ◽  
Kai Kaarniranta
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Animal Models ◽  
Dry Eye ◽  
Ocular Surface ◽  
Stress Protein ◽  
Life Forms ◽  
Beneficial Effects ◽  
Protein Clearance ◽  
Ocular Surface Health

Trehalose is a natural disaccharide synthesized in various life forms, but not found in vertebrates. An increasing body of evidence demonstrates exceptional bioprotective characteristics of trehalose. This review discusses the scientific findings on potential functions of trehalose in oxidative stress, protein clearance, and inflammation, with an emphasis on animal models and clinical trials in ophthalmology. The main objective is to help understand the beneficial effects of trehalose in clinical trials and practice, especially in patients suffering from ocular surface disease. The discussion is supplemented with an overview of patents for the use of trehalose in dry eye and with prospects for the 2020s.

scholarly journals Influence of BAK-Preserved Prostaglandin Analog Treatment on the Ocular Surface Health in Patients with Newly Diagnosed Primary Open-Angle Glaucoma

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Martina Tomić ◽  
Snježana Kaštelan ◽  
Kata Metež Soldo ◽  
Jasminka Salopek-Rabatić
Keyword(s):  
Intraocular Pressure ◽  
Ocular Surface ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Final Visit ◽  
Open Angle ◽  
Newly Diagnosed ◽  
Prostaglandin Analog ◽  
Ocular Surface Health

Purpose. Primary open-angle glaucoma (POAG), a chronic, degenerative optic neuropathy, requires persistent decrease of intraocular pressure so as to prevent visual impairment and blindness. However, long-term use of topical ocular medications may affect ocular surface health. Purpose of this study was to evaluate the influence of BAK-preserved prostaglandin analog treatment on the ocular surface health in patients with newly diagnosed POAG.Methods. 40 newly diagnosed POAG patients were included in this prospective study. Intraocular pressure (IOP), tear break-up time (TBUT), and ocular surface disease index (OSDI) were assessed at baseline and 3-month after starting treatment with BAK-preserved travoprost 0.004%.Results. IOP decreased in all patients from baseline to 3-month final visit (23.80 ± 1.73 mmHg versus 16.78 ± 1.27 mmHg;P<0.001). Mean TBUT decreased from11.70±1.86seconds at baseline to 8.30 ± 1.29 seconds at 3-month final visit (<0.001). Mean OSDI score increased from 31.63 ± 18.48 to 44.41 ± 16.48 (P<0.001).Conclusions. This study showed that BAK-preserved travoprost 0.004% is an effective medication in newly diagnosed POAG patients, but its long-term use may negatively influence ocular surface health by disrupting the tear film stability. Further studies are needed to better understand the clinical effects of different preservative types and concentrations on the ocular surface.

Optimizing Refractive Outcomes in the Presence of Ocular Allergy—Toward a Comprehensive Approach to Ocular Surface Health

2012 ◽  
Vol 05 (01) ◽  
pp. 53
Author(s):  
Terrence P O’Brien ◽  
Keyword(s):  
Contact Lens ◽  
Ocular Surface ◽  
Allergic Conjunctivitis ◽  
Refractive Surgery ◽  
Ocular Allergy ◽  
Refractive Outcomes ◽  
Ocular Surface Health ◽  
Relationship Of ◽  
The Relationship

Seasonal and perennial allergic conjunctivitis are common conditions which, along with dry eye and other inflammatory disorders of the ocular surface, may present an underlying management challenge in refractive surgery. Optimizing the condition and health of the ocular surface is essential in contact lens wearers, refractive surgical candidates, and post-surgical patients alike. Achieving an optimal ocular surface demands a comprehensive understanding of ocular allergy and related ocular surface conditions, as well as a proactive therapeutic approach. Although ocular allergy has often been implicated in contact lens intolerance, research has now begun to document the potential impact of allergic conjunctivitis on refractive surgical outcomes as well. Additional studies are needed to understand the relationship of allergic conjunctivitis to concomitant ocular surface disease and long-term ocular surface health. Further investigation of the potential benefit of better management of chronic episodic ocular surface inflammation, particularly in refractive surgery, will assist with the identification of optimal therapies.

scholarly journals Enhanced ocular surface and intraoral nociception via a TRPV1 mechanism in a rat model of obstructive sleep apnea

Neuroscience ◽  
2021 ◽  
Author(s):  
Saki Kishimoto ◽  
Ayano Katagiri ◽  
Aiko Oyamaguchi ◽  
Hajime Sato ◽  
Hiroki Toyoda ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Rat Model ◽  
Ocular Surface ◽  
Obstructive Sleep

scholarly journals A comparative study of benzalkonium chloride-free latanoprost versus benzalkonium chloride-preserved latanoprost on ocular surface health in patients of primary open angle glaucoma

2017 ◽  
Vol 6 (5) ◽  
pp. 1110 ◽  
Author(s):  
Hema Chhabra ◽  
Anita Gupta ◽  
Gursatinder Singh
Keyword(s):  
Ocular Surface ◽  
Benzalkonium Chloride ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Tear Film ◽  
Ocular Surface Disease ◽  
Open Angle ◽  
Schirmer Test ◽  
Break Up ◽  
Ocular Surface Health

Background: Prolonged use of anti-glaucoma therapy leads to development of ocular surface disease (OSD). The purpose of this study was to compare the effect of Benzalkonium chloride (BKC)-free latanoprost and Benzalkonium chloride (BKC)-preserved latanoprost on ocular surface health in patients of primary open angle glaucoma (POAG).Methods: This was a prospective, open-label, randomized, interventional, switch trial. 30 established cases of POAG who were already on BKC-preserved latanoprost for atleast more than three months were enrolled. Their Schirmer test and Tear film break-up time (TBUT) were recorded at the baseline. They were required to answer an ocular surface disease index (OSDI) questionnaire from which an OSDI score was calculated. They were switched to BKC-free latanoprost for another three months. On their follow-up visit at 6 weeks and 12 weeks, Schirmer test and Tear film break up time were performed again and OSDI score was calculated.Results: Schirmer test increased from 6.73±3.77 mm at baseline to 9.53±3.67 mm at 6 weeks and 11.97±3.53 mm at 12 weeks (p=0.001). Mean TBUT improved significantly from 6.77±3.82 seconds at baseline to 8.63±3.91 seconds at 6 weeks to 10.47±3.76 seconds at 12 weeks (p=0.001). OSDI score decreased from 31.55±23.32 at baseline to 23.42±21.93 at 6 weeks to 15.82±20.10 at 12 weeks (p=0.001).Conclusions: BKC-free latanoprost led to improvement in tear film status or ocular surface health of glaucoma patients as compared to BKC-preserved latanoprost.

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