Effects of Substance P and IGF-1 in Corneal Epithelial Barrier Function and Wound Healing in a Rat Model of Neurotrophic Keratopathy

2003 ◽  
Vol 44 (9) ◽  
pp. 3810 ◽  
Author(s):  
Takashi Nagano ◽  
Masatsugu Nakamura ◽  
Katsuhiko Nakata ◽  
Takeshi Yamaguchi ◽  
Kenji Takase ◽  
...  
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Rat Model ◽  
Barrier Function ◽  
Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Corneal Epithelial ◽  
Neurotrophic Keratopathy

Effect of Beta-Blocker Eyedrops on Corneal Epithelial Barrier Function

2000 ◽  
Vol 214 (5) ◽  
pp. 332-336 ◽  
Author(s):  
Akiko Niiya ◽  
Norihiko Yokoi ◽  
Yasuhiro Matsumoto ◽  
Aoi Komuro ◽  
Takeshi Ishibashi ◽  
...  
Keyword(s):  
Beta Blocker ◽  
Barrier Function ◽  
Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Corneal Epithelial

scholarly journals Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Naoto Tokuda ◽  
Yasushi Kitaoka ◽  
Akiko Matsuzawa ◽  
Ayaka Tsukamoto ◽  
Kana Sase ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Barrier Function ◽  
Benzalkonium Chloride ◽  
Tear Film ◽  
Ophthalmic Solution ◽  
Surface Characteristics ◽  
Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Corneal Epithelial ◽  
Preservative Free

Purpose. The aim of the present study was to examine the effects of switching from Latanoprost ophthalmic solution containing a preservative to preservative-free Tafluprost ophthalmic solution or Tafluprost containing a preservative on ocular surfaces. Materials and Methods. Forty patients (40 eyes) with glaucoma (mean age: 62.0 ± 10.9 years) using Latanoprost with preservative for six months or longer were assigned either to a Tafluprost-containing-preservative group (20 eyes) or preservative-free-Tafluprost group (20 eyes). The intraocular pressure, corneal epithelial barrier function (fluorescein uptake concentration with fluorophotometer FL-500), superficial punctate keratopathy (AD classification), and tear film breakup time (TBUT) were assessed before switching and at 12 weeks after switching. Results. No significant differences in intraocular pressure were noted after switching in either group. Corneal epithelial barrier function was improved significantly after switching in both the Tafluprost-containing-preservative and the preservative-free-Tafluprost groups. There were no significant differences in AD scores after switching in the Tafluprost-containing-preservative group, but significant improvements were noted in the preservative-free-Tafluprost group. No significant differences in TBUT were noted in the Tafluprost-containing-preservative or preservative-free-Tafluprost groups after switching. Conclusion. After switching from preservative Latanoprost to Tafluprost containing-preservative or preservative-free Tafluprost, corneal epithelial barrier function was improved while the intraocular pressure reduction was retained.

Protective effect of substance P on permeability of airway epithelial cells in culture

1996 ◽  
Vol 271 (6) ◽  
pp. L889-L895
Author(s):  
X. Y. Yu ◽  
B. J. Undem ◽  
E. W. Spannhake
Keyword(s):  
Substance P ◽  
Protective Effect ◽  
Barrier Function ◽  
Protective Role ◽  
Airway Epithelial Cells ◽  
Epithelial Barrier ◽  
Airway Epithelial ◽  
Bronchial Epithelial ◽  
Epithelial Barrier Function ◽  
Nk3 Receptor

Although substance P (SP) has been shown to mediate microvascular leakage in response to various stimuli, some data suggest that, in contrast, SP may play a protective role in the maintenance of airway epithelial integrity. To investigate the effect of SP on epithelial barrier function, we measured paracellular mannitol flux and the transepithelial potential difference (PD) of human bronchial epithelial (HBE) and canine bronchial epithelial (CBE) cells. Incubation of confluent cell cultures with SP had no effect on baseline flux. However, pretreatment inhibited the flux-enhancing effects of 0.5 ppm ozone by 50% in HBE cells and 40% in CBE cells and inhibited the ozone-induced decrease in PD in CBE cells by 54%. SP-afforded protection was reduced by the neurokinin (NK)-1 receptor antagonist CP-96,345.NK1 and NK3 receptor agonists also inhibited ozone-induced permeability, whereas an NK2 receptor agonist was without significant effect. These data indicate that SP exerts a protective effect on bronchial epithelial barrier function under conditions of challenge, which appears to be mediated in large part through NK1 receptors.

scholarly journals P 154 Effects of contact lens use to corneal epithelial barrier function by objective fluorophotometer

1995 ◽  
Vol 35 ◽  
pp. S180
Author(s):  
T. Takahashi ◽  
Y. Enomoto ◽  
M. Itoi ◽  
N. Itoh ◽  
K. Nakayasu ◽  
...  
Keyword(s):  
Contact Lens ◽  
Barrier Function ◽  
Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Corneal Epithelial

Impairment of corneal epithelial barrier function in diabetics

1989 ◽  
Vol 227 (2) ◽  
pp. 142-144 ◽  
Author(s):  
Martin Göbbels ◽  
Manfred Spitznas ◽  
Joachim Oldendoerp
Keyword(s):  
Barrier Function ◽  
Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Corneal Epithelial

Contact Lens Care Solutions and Corneal Epithelial Barrier Function: A Fluorophotometric Study

1994 ◽  
Vol 26 (3) ◽  
pp. 129-136 ◽  
Author(s):  
Ed.P.M. Boets ◽  
Martin J. Kerkmeer ◽  
Jaap A. van Best
Keyword(s):  
Contact Lens ◽  
Barrier Function ◽  
Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Corneal Epithelial
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