scholarly journals Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion

2018 ◽  
Vol 59 (11) ◽  
pp. 4701 ◽  
Author(s):  
Anri Nishinaka ◽  
Yuki Inoue ◽  
Shinichiro Fuma ◽  
Yoshifumi Hida ◽  
Shinsuke Nakamura ◽  
...  
Keyword(s):  
Retinal Vein Occlusion ◽  
Retinal Edema ◽  
Vein Occlusion ◽  
Pathophysiological Role

Creation of retinal vein occlusion model in cynomolgusmonkeys and determination of its pathological features

2020 ◽  
Vol 17 ◽  
Author(s):  
Satoshi Inagaki ◽  
Masamitsu Shimazawa ◽  
Wataru Otsu ◽  
Tomoaki Araki ◽  
Yosuke Numata ◽  
...  
Keyword(s):  
Growth Factors ◽  
Retinal Vein Occlusion ◽  
Vascular System ◽  
Retinal Thickness ◽  
Chronic Phase ◽  
Vascular Leakage ◽  
Foveal Avascular Zone ◽  
Retinal Edema ◽  
Vein Occlusion ◽  
Angiopoietin 2

Objective: A retinal vein occlusion (RVO) is a relatively common retinal vascular disorder especially in the elder-ly. Many experiments have been performed on patients with a RVO but performing any type of experiments and especially longitudinal experiments on humans is difficult if not impossible on ethical grounds. Therefore, we have created a retinal vein occlusion (RVO) model by laser irradiation of cynomolgus monkeysafter an intravenous injection of rose bengal. Weevaluated the pathological changes of the retina, and the effects of ranibizumab, an anti-vascular endothelial growth factor (VEGF) antibody, on the characteristics of the RVO. Methods: The integrity of the vascular system was evaluated by fluorescein angiography (FA), and the retinal thickness and volume were determined by optical coherence tomography (OCT). The cytokines and growth factors in the aqueous humor were identified by multiplex profiling. Results: Our results showed that ranibizumab decreased the degree of vascular leakage and retinal edema at 1-3 days (acute phase) and 3-7 days (subacute phase), and suppressed foveal thinning at 28-42 days (chronic phase) after the laser irradia-tion. Ranibizumab also decreased the area of the foveal avascular zone, and the area was negatively and significantly corre-lated with the thickness of the ganglion cell layer (GCL) complex. Furthermore, ranibizumab reduced the increased expres-sion of VEGF in the aqueous humour, but did not affect the expressions of interleukin-6 (IL-6), monocyte chemotactic pro-tein-1 (MCP-1), angiopoietin-1 (ANG-1), or angiopoietin-2 (ANG-2).Thesefindings suggest that ranibizumab attenuates the retinal edema and subsequent retinal atrophy in partby neutralizing VEGF. However, other cytokines and growth factors were also affected by the ranibizumab which suggests that not only VEGF but also other unidentified agents might play a role in the pathogenesis of the RVO. Conclusion: We have created a non-human primate RVO model, which resembles the clinical RVO pathology. In this model, an injection of ranibizumab leads to a reduction in the vascular leakage and the retinal thickness and volume by blockingthe expression of VEGF. Our model might be useful for investigating the pathological mechanisms of RVOs and explore new therapeutic agents for RVO.

scholarly journals The role of coagulation disorders in patients with retinal vein occlusion

QJM ◽  
2015 ◽  
Vol 109 (2) ◽  
pp. 97-102 ◽  
Author(s):  
J.J. Napal ◽  
S. Neila ◽  
R. Pérez-Montes ◽  
I. Sierra ◽  
S. Ruiz ◽  
...  
Keyword(s):  
Retinal Vein Occlusion ◽  
Coagulation Disorders ◽  
Vein Occlusion

scholarly journals The Role of Inflammation in the Pathogenesis of Macular Edema Secondary to Retinal Vascular Diseases

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Francisco J. Ascaso ◽  
Valentín Huerva ◽  
Andrzej Grzybowski
Keyword(s):  
Macular Edema ◽  
Adhesion Molecules ◽  
Retinal Vein Occlusion ◽  
Diabetic Macular Edema ◽  
Inflammatory Mediators ◽  
Vascular Diseases ◽  
Vein Occlusion ◽  
Inflammatory Processes ◽  
Nonspecific Sign

Macular edema (ME) is a nonspecific sign of numerous retinal vascular diseases. This paper is an updated overview about the role of inflammatory processes in the genesis of both diabetic macular edema (DME) and ME secondary to retinal vein occlusion (RVO). We focus on the inflammatory mediators implicated, the effect of the different intravitreal therapies, the recruitment of leukocytes mediated by adhesion molecules, and the role of retinal Müller glial (RMG) cells.

scholarly journals Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice

2018 ◽  
Vol 59 (8) ◽  
pp. 3355 ◽  
Author(s):  
Michael J. Allingham ◽  
Nomingerel Tserentsoodol ◽  
Peter Saloupis ◽  
Priyatham S. Mettu ◽  
Scott W. Cousins
Keyword(s):  
Retinal Vein Occlusion ◽  
Retinal Edema ◽  
Vein Occlusion

The role of thrombophilia in patients with retinal vein occlusion and no systemic risk factors

2010 ◽  
Vol 45 (2) ◽  
pp. 171-175 ◽  
Author(s):  
Matus Rehak ◽  
Vera Krcova ◽  
Ludek Slavik ◽  
Evzen Fric ◽  
Katerina Langova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retinal Vein Occlusion ◽  
Systemic Risk ◽  
Vein Occlusion ◽  
Systemic Risk Factors

Role of the Vitreous and Macular Edema in Branch Retinal Vein Occlusion

1997 ◽  
Vol 28 (4) ◽  
pp. 294-299
Author(s):  
Masatoshi K Takihashi ◽  
Taiichi Hikichi ◽  
Jun Akiba ◽  
Akitoshi Yoshida ◽  
Clement L Trempe
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Vein Occlusion
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