scholarly journals Application of In Vivo Confocal Microscopy in Dry Eye Disease

2018 ◽  
Vol 59 (14) ◽  
pp. DES41 ◽  
Author(s):  
Yukihiro Matsumoto ◽  
Osama M. A. Ibrahim
Keyword(s):  
Confocal Microscopy ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
In Vivo Confocal Microscopy

Alterations in corneal nerves in different subtypes of dry eye disease: An in vivo confocal microscopy study

2021 ◽  
Author(s):  
Stephanie M. Cox ◽  
Ahmad Kheirkhah ◽  
Shruti Aggarwal ◽  
Farshad Abedi ◽  
Bernardo M. Cavalcanti ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Dry Eye ◽  
Microscopy Study ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
In Vivo Confocal Microscopy ◽  
Corneal Nerves

Identification of Objective Morphometric Markers of Xerostomia in the Oral Mucosa Epithelium with In Vivo Confocal Microscopy

2017 ◽  
Vol 23 (1) ◽  
pp. 88-96
Author(s):  
Ida G. Fostad ◽  
Jon R. Eidet ◽  
Neil S. Lagali ◽  
Darlene A. Dartt ◽  
Sten Ræder ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Oral Mucosa ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Lower Lip ◽  
Gender And Age ◽  
And Gender ◽  
Mucosa Epithelium

AbstractThe purpose of this work was to determine whether the morphology of the oral mucosa epithelium (OME) of patients with xerostomia differ from patients without xerostomia. In total, 34 patients with dry eye disease (DED) with or without xerostomia were examined at The Norwegian Dry Eye Disease Clinic with in vivo confocal microscopy of the lower lip. In addition, age- and gender-matched healthy controls (HC) were included. DED patients with xerostomia had a higher superficial to deep backscatter ratio compared with DED patients without xerostomia (p=0.002) and HC (p=0.001). Regression analysis demonstrated that this ratio was related to xerostomia independently of gender and age (p<0.001). Sensitivity and specificity of detecting xerostomia were 0.78 and 0.85, respectively, when using a superficial to deep backscatter ratio cut-off value of 0.995 (p=0.004). The mean nucleus to cytosol backscatter ratio in the superficial OME was lower in patients with xerostomia than in those without xerostomia (p=0.034). In vivo confocal microscopy is a potential tool for evaluating the oral cavity and to assess changes in the OME associated with xerostomia, objectively and quantitatively. The cause of the increased backscatter in the superficial OME in xerostomia, however, remains to be elucidated.

scholarly journals Corneal Epithelial Immune Dendritic Cell Alterations in Subtypes of Dry Eye Disease: A Pilot In Vivo Confocal Microscopic Study

2015 ◽  
Vol 56 (12) ◽  
pp. 7179 ◽  
Author(s):  
Ahmad Kheirkhah ◽  
Raheleh Rahimi Darabad ◽  
Andrea Cruzat ◽  
Amir Reza Hajrasouliha ◽  
Deborah Witkin ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Microscopic Study ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Corneal Epithelial ◽  
Cell Alterations ◽  
Confocal Microscopic Study

scholarly journals Manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin, a superoxide dismutase mimetic, reduces disease severity in in vitro and in vivo models for dry-eye disease

2019 ◽  
Vol 17 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Agnė Žiniauskaitė ◽  
Symantas Ragauskas ◽  
Anita K. Ghosh ◽  
Rubina Thapa ◽  
Anne E. Roessler ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Disease Severity ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
In Vivo Models
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