scholarly journals In Vivo Confocal Microscopy in Dry Eye Disease Associated With Chronic Graft-Versus-Host Disease

2016 ◽  
Vol 57 (11) ◽  
pp. 4686 ◽  
Author(s):  
Ahmad Kheirkhah ◽  
Yureeda Qazi ◽  
Michael A. Arnoldner ◽  
Kunal Suri ◽  
Reza Dana
Keyword(s):  
Confocal Microscopy ◽  
Dry Eye ◽  
Graft Versus Host Disease ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
In Vivo Confocal Microscopy ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Reduced Efficacy of Low-dose Topical Steroids in Dry Eye Disease Associated With Graft-versus-Host Disease

2018 ◽  
Vol 190 ◽  
pp. 17-23 ◽  
Author(s):  
Jia Yin ◽  
Ahmad Kheirkhah ◽  
Thomas Dohlman ◽  
Ujwala Saboo ◽  
Reza Dana
Keyword(s):  
Dry Eye ◽  
Graft Versus Host Disease ◽  
Low Dose ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Topical Steroids ◽  
Host Disease ◽  
Graft Versus Host

Dry Eye Disease in Chronic Graft-Versus-Host Disease: Results From a Spanish Retrospective Cohort Study

2011 ◽  
Vol 43 (5) ◽  
pp. 1934-1938 ◽  
Author(s):  
P. de la Parra-Colín ◽  
A.L.D. Agahan ◽  
J.A. Pérez-Simón ◽  
A. López ◽  
D. Caballero ◽  
...  
Keyword(s):  
Cohort Study ◽  
Dry Eye ◽  
Graft Versus Host Disease ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Host Disease ◽  
Graft Versus Host

Corneal features in ocular graft-versus-host disease by in vivo confocal microscopy

2017 ◽  
Vol 255 (12) ◽  
pp. 2389-2397 ◽  
Author(s):  
Tudor C. Tepelus ◽  
Gloria B. Chiu ◽  
Jyotsna Maram ◽  
Jianyan Huang ◽  
Vikas Chopra ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Graft Versus Host Disease ◽  
In Vivo Confocal Microscopy ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Observation of Chronic Graft-Versus-Host Disease Mouse Model Cornea with In Vivo Confocal Microscopy

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1515
Author(s):  
Shota Shimizu ◽  
Shinri Sato ◽  
Hiroko Taniguchi ◽  
Eisuke Shimizu ◽  
Jingliang He ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Mouse Model ◽  
Graft Versus Host Disease ◽  
Pathological Condition ◽  
Inflammatory Cells ◽  
In Vivo Confocal Microscopy ◽  
Host Disease ◽  
Epithelial Damage ◽  
Graft Versus Host

Graft-versus-host disease (GVHD) is a major complication after hematopoietic stem cell transplantation (HSCT), and ocular GVHD can cause severe dry eye disease that can lead to visual impairment. Epithelial damage, vascular invasion, corneal fibrosis, and corneal perforation may occur in severe cases. It is generally accepted that inflammatory cells such as dendritic cells and T cells contribute to this pathological condition. However, it is still unknown what pathological condition occurs on the ocular surface after HSCT, and when. We therefore observed the dynamics of inflammatory cells in the cornea of chronic GVHD (cGVHD) model mice from 1 to 4 weeks after bone marrow transplantation (BMT) by in vivo confocal microscopy (IVCM) and considered the relationship with the pathophysiology of ocular GVHD (tear volume, corneal epithelial damage). In the allogeneic group, neovascularization occurred in all eyes at 1 week after BMT, although almost all vessels disappeared at 2 weeks after BMT. In addition, we revealed that infiltration of globular cells, and tortuosity and branching of nerves in the cornea occurred in both cGVHD mice and human cGVHD patients. Thus, we consider that cGVHD mouse model study by IVCM reproduces the state of ocular GVHD and may contribute to elucidating the pathological mechanism for ocular GVHD.

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