scholarly journals Potential Role of Zinc Dyshomeostasis in Matrix Metalloproteinase-2 and -9 Activation and Photoreceptor Cell Death in Experimental Retinal Detachment

2018 ◽  
Vol 59 (7) ◽  
pp. 3058 ◽  
Author(s):  
Jeong A Choi ◽  
Yoon Jeon Kim ◽  
Bo-Ra Seo ◽  
Jae-Young Koh ◽  
Young Hee Yoon
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Matrix Metalloproteinase ◽  
Potential Role ◽  
Photoreceptor Cell ◽  
Matrix Metalloproteinase 2

scholarly journals Potential role of increased matrix metalloproteinase-2 (MMP2) transcription in impaired adipogenesis in type 2 diabetes mellitus

2008 ◽  
Vol 367 (4) ◽  
pp. 725-728 ◽  
Author(s):  
Severine G. Dubois ◽  
Yourka D. Tchoukalova ◽  
Leonie K. Heilbronn ◽  
Jeanine B. Albu ◽  
David E. Kelley ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Matrix Metalloproteinase ◽  
Potential Role ◽  
Matrix Metalloproteinase 2

Type I collagen from sea cucumber (Stichopus japonicus) and the role of matrix metalloproteinase-2 in autolysis

2021 ◽  
Vol 41 ◽  
pp. 100959
Author(s):  
Long-Jie Yan ◽  
Le-Chang Sun ◽  
Kai-Yuan Cao ◽  
Yu-Lei Chen ◽  
Ling-Jing Zhang ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Sea Cucumber ◽  
Type I Collagen ◽  
Matrix Metalloproteinase 2 ◽  
Type I ◽  
Stichopus Japonicus

scholarly journals Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment

2014 ◽  
Vol 5 (5) ◽  
pp. e1269-e1269 ◽  
Author(s):  
H Matsumoto ◽  
Y Murakami ◽  
K Kataoka ◽  
H Lin ◽  
K M Connor ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Photoreceptor Cell

scholarly journals Edaravone, an ROS Scavenger, Ameliorates Photoreceptor Cell Death after Experimental Retinal Detachment

2011 ◽  
Vol 52 (6) ◽  
pp. 3825 ◽  
Author(s):  
Mi In Roh ◽  
Yusuke Murakami ◽  
Aristomenis Thanos ◽  
Demetrios G. Vavvas ◽  
Joan W. Miller
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Photoreceptor Cell ◽  
Ros Scavenger

scholarly journals Piezo1 mediates angiogenesis through activation of MT1-MMP signaling

2019 ◽  
Vol 316 (1) ◽  
pp. C92-C103 ◽  
Author(s):  
Hojin Kang ◽  
Zhigang Hong ◽  
Ming Zhong ◽  
Jennifer Klomp ◽  
Kayla J. Bayless ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Sprouting Angiogenesis ◽  
Sphingosine 1 Phosphate ◽  
Wall Shear ◽  
Membrane Type

Angiogenesis is initiated in response to a variety of external cues, including mechanical and biochemical stimuli; however, the underlying signaling mechanisms remain unclear. Here, we investigated the proangiogenic role of the endothelial mechanosensor Piezo1. Genetic deletion and pharmacological inhibition of Piezo1 reduced endothelial sprouting and lumen formation induced by wall shear stress and proangiogenic mediator sphingosine 1-phosphate, whereas Piezo1 activation by selective Piezo1 activator Yoda1 enhanced sprouting angiogenesis. Similarly to wall shear stress, sphingosine 1-phosphate functioned by activating the Ca2+ gating function of Piezo1, which in turn signaled the activation of the matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase during sprouting angiogenesis. Studies in mice in which Piezo1 was conditionally deleted in endothelial cells demonstrated the requisite role of sphingosine 1-phosphate-dependent activation of Piezo1 in mediating angiogenesis in vivo. These results taken together suggest that both mechanical and biochemical stimuli trigger Piezo1-mediated Ca2+ influx and thereby activate matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase and synergistically facilitate sprouting angiogenesis.

scholarly journals Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling

2018 ◽  
Vol 9 ◽  
Author(s):  
Yu Kuwabara ◽  
Tetsu Kobayashi ◽  
Corina N. D'Alessandro-Gabazza ◽  
Masaaki Toda ◽  
Taro Yasuma ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Airway Remodeling ◽  
Matrix Metalloproteinase 2
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