scholarly journals The Intraocular Lens as a Drug Delivery Device: In Vitro Screening of Pharmacologic Substances for the Prophylaxis of Posterior Capsule Opacification

2017 ◽  
Vol 58 (14) ◽  
pp. 6408 ◽  
Author(s):  
Christian Wertheimer ◽  
Stefan Kassumeh ◽  
Nick P. Piravej ◽  
Olga Nilmayer ◽  
Christian Braun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intraocular Lens ◽  
Posterior Capsule Opacification ◽  
Posterior Capsule ◽  
In Vitro Screening ◽  
Delivery Device ◽  
Drug Delivery Device

DC Bead: In Vitro Characterization of a Drug-delivery Device for Transarterial Chemoembolization

2006 ◽  
Vol 17 (2) ◽  
pp. 335-342 ◽  
Author(s):  
Andrew L. Lewis ◽  
M. Victoria Gonzalez ◽  
Andrew W. Lloyd ◽  
Brenda Hall ◽  
Yiqing Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transarterial Chemoembolization ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
In Vitro Characterization

scholarly journals Evaluation of a chloroaluminium phthalocyanine-loaded magnetic nanoemulsion as a drug delivery device to treat glioblastoma using hyperthermia and photodynamic therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 9115-9122 ◽  
Author(s):  
L. B. de Paula ◽  
F. L. Primo ◽  
M. R. Pinto ◽  
P. C. Morais ◽  
A. C. Tedesco
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cell Lines ◽  
Maghemite Nanoparticles ◽  
Delivery Device ◽  
Drug Delivery Device

The study describes the development of magnetic nanoemulsion loaded with citrate-coated maghemite nanoparticles and photosensitizer and the in vitro studies using cell lines while combining the use of hyperthermia and photodynamic therapy therapies.

In Vitro–In Vivo Evaluation of an Oral Ghost Drug Delivery Device for the Delivery of Salmon Calcitonin

2018 ◽  
Vol 107 (6) ◽  
pp. 1605-1614 ◽  
Author(s):  
Angus R. Hibbins ◽  
Mershen Govender ◽  
Sunaina Indermun ◽  
Pradeep Kumar ◽  
Lisa C. du Toit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Salmon Calcitonin ◽  
Delivery Device ◽  
In Vivo Evaluation ◽  
Drug Delivery Device

scholarly journals Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

2013 ◽  
Vol 4 (1) ◽  
pp. 14-26 ◽  
Author(s):  
Nathan Gooch ◽  
Randon Burr ◽  
Dolly Holt ◽  
Bruce Gale ◽  
Balamurali Ambati
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
In Vitro Biocompatibility

scholarly journals A 3D Printed Self-Sustainable Cell-Encapsulation Drug Delivery Device for Periocular Transplant-Based Treatment of Retinal Degenerative Diseases

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 436 ◽  
Author(s):  
Hideto Kojima ◽  
Bibek Raut ◽  
Li-Jiun Chen ◽  
Nobuhiro Nagai ◽  
Toshiaki Abe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Retinal Pigment ◽  
Cell Encapsulation ◽  
Degenerative Diseases ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
3D Printed ◽  
Retinal Degenerative Diseases

Self-sustainable release of brain-derived neurotrophic factor (BDNF) to the retina using minimally invasive cell-encapsulation devices is a promising approach to treat retinal degenerative diseases (RDD). Herein, we describe such a self-sustainable drug delivery device with human retinal pigment epithelial (ARPE-19) cells (cultured on collagen coated polystyrene (PS) sheets) enclosed inside a 3D printed semi-porous capsule. The capsule was 3D printed with two photo curable polymers: triethylene glycol dimethacrylate (TEGDM) and polyethylene glycol dimethylacrylate (PEGDM). The capsule’s semi-porous membrane (PEGDM) could serve three functions: protecting the cells from body’s immune system by limiting diffusion (5.97 ± 0.11%) of large molecules like immunoglobin G (IgG)(150 kDa); helping the cells to survive inside the capsule by allowing diffusion (43.20 ± 2.16%) of small molecules (40 kDa) like oxygen and necessary nutrients; and helping in the treatment of RDD by allowing diffusion of cell-secreted BDNF to the outside environment. In vitro results showed a continuous BDNF secretion from the device for at least 16 days, demonstrating future potential of the cell-encapsulation device for the treatment of RDD in a minimally invasive and self-sustainable way through a periocular transplant.

Sign in / Sign up

Export Citation Format

Share Document