scholarly journals Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids in a Rat Model of Anterior Ischemic Optic Neuropathy

2017 ◽  
Vol 58 (3) ◽  
pp. 1603 ◽  
Author(s):  
Tassos Georgiou ◽  
Yao-Tseng Wen ◽  
Chung-Hsing Chang ◽  
Panagiotis Kolovos ◽  
Maria Kalogerou ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Optic Neuropathy ◽  
Rat Model ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Omega 3 ◽  
Neuroprotective Effects

The combined action of omega-3 polyunsaturated fatty acids and grape proanthocyanidins on a rat model of diet-induced metabolic alterations

2016 ◽  
Vol 7 (8) ◽  
pp. 3516-3523 ◽  
Author(s):  
Sara Ramos-Romero ◽  
Eunice Molinar-Toribio ◽  
Jara Pérez-Jiménez ◽  
Núria Taltavull ◽  
Gabriel Dasilva ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Rat Model ◽  
Metabolic Changes ◽  
Omega 3 ◽  
Metabolic Alterations ◽  
Combined Action

A combination of ω-3 PUFAs (EPA/DHA 1 : 1) and proanthocyanidins reverts metabolic changes induced by an energy-dense diet, more effectively than either supplement individually.

scholarly journals Protective Effects of Intravitreal Injection of the Rho-Kinase Inhibitor Y-27632 in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rAION)

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Zuohuizi Yi ◽  
Liao Chen ◽  
Xiaoling Wang ◽  
Changzheng Chen ◽  
Yiqiao Xing
Keyword(s):  
Intravitreal Injection ◽  
Optic Neuropathy ◽  
Visual Function ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Rodent Model ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Neuroprotective Effects ◽  
Rho Kinase Inhibitor

Purpose. We sought to explore the effects of intravitreal injection of the Rho-kinase inhibitor Y-27632 in a rodent model of nonarteritic anterior ischemic optic neuropathy (rAION). Methods. The rAION model was established by using laser-induced photoactivation of intravenously administered Rose Bengal in rats. The rats received intravitreal injections of Y-27632 or PBS 1, 3, and 6 days after rAION induction. Optical coherence tomography (OCT) was performed at 2 days and 4 weeks after induction. Visual evoked potential (VEP) was used to evaluate the visual function at 4 weeks. Brn3a immunofluorescence staining of surviving RGCs and apoptosis assays of RGCs were performed at 4 weeks. Results. Optic nerve head (ONH) width was significantly reduced in the Y-27632 group compared with that in the PBS group at 2 days after induction (p<0.05). At 4 weeks, the P1 amplitude of flash-VEP (FVEP) in the Y-27632 group was significantly higher than that of the PBS group (p<0.05). The RGC densities in the central and midperipheral retinas in the Y-27632 group were significantly higher than those in the PBS group (p<0.05). Furthermore, there was a significant decrease in apoptotic RGCs in the Y-27632 group than in the PBS group (p<0.05). Conclusions. Intravitreal injection of Y-27632 had neuroprotective effects on ONH edema, RGC survival, and visual function preservation in rAION.

scholarly journals MP63-01 PREVENTATIVE EFFECT OF OMEGA-3 POLYUNSATURATED FATTY ACIDS (N-3 PUFAS) AGAINST INDUCTION OF BLADDER CANCER (BC) IN A RAT MODEL

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Mohamed Fadallah* ◽  
EL Housseiny I. Ibrahiem ◽  
Ahmed M. El-Assmy ◽  
Nashwa M. Barakat ◽  
Sherry Khater ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Bladder Cancer ◽  
Polyunsaturated Fatty Acids ◽  
Rat Model ◽  
Omega 3
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