The combined action of omega-3 polyunsaturated fatty acids and grape proanthocyanidins on a rat model of diet-induced metabolic alterations

2016 ◽  
Vol 7 (8) ◽  
pp. 3516-3523 ◽  
Author(s):  
Sara Ramos-Romero ◽  
Eunice Molinar-Toribio ◽  
Jara Pérez-Jiménez ◽  
Núria Taltavull ◽  
Gabriel Dasilva ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Rat Model ◽  
Metabolic Changes ◽  
Omega 3 ◽  
Metabolic Alterations ◽  
Combined Action

A combination of ω-3 PUFAs (EPA/DHA 1 : 1) and proanthocyanidins reverts metabolic changes induced by an energy-dense diet, more effectively than either supplement individually.

scholarly journals MP63-01 PREVENTATIVE EFFECT OF OMEGA-3 POLYUNSATURATED FATTY ACIDS (N-3 PUFAS) AGAINST INDUCTION OF BLADDER CANCER (BC) IN A RAT MODEL

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Mohamed Fadallah* ◽  
EL Housseiny I. Ibrahiem ◽  
Ahmed M. El-Assmy ◽  
Nashwa M. Barakat ◽  
Sherry Khater ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Bladder Cancer ◽  
Polyunsaturated Fatty Acids ◽  
Rat Model ◽  
Omega 3

scholarly journals The Mechanisms of the Anti-Inflammatory and Anti-Apoptotic Effects of Omega-3 Polyunsaturated Fatty Acids during Methotrexate-Induced Intestinal Damage in Cell Line and in a Rat Model

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 888
Author(s):  
Tal Koppelmann ◽  
Yulia Pollak ◽  
Yoav Ben-Shahar ◽  
Gregory Gorelik ◽  
Igor Sukhotnik
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Cell Viability ◽  
Rat Model ◽  
Intestinal Damage ◽  
Omega 3 ◽  
Tnf Α ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Ht 29

Background: The aim of this study was to examine the anti-inflammatory and anti-apoptotic patterns of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during methotrexate (MTX) induced intestinal damage in cell culture and in a rat model. Methods: Non-treated and treated with MTX HT 29 and HCT116cells were exposed to increasing doses of n-3 PUFAs and cell viability was evaluated using PrestoBlue® assay. Male Sprague-Dawley rats were divided into 4 experimental groups: Control rats, CONTR+n-3 PUFA rats that were treated with oral n-3 PUFA, MTX rats were treated with MTX given IP, and MTX+n-3 PUFA rats were treated with oral n-3 PUFA before and following injection of MTX. Intestinal mucosal parameters and mucosal inflammation, enterocyte proliferation and apoptosis, TNF-α in mucosal tissue and plasma (ELISA), NF-κB, COX-2, TNF-α, Fas, FasL, Fadd, Bid, Bax and Bcl-2gene and protein levels were determined 72 h following MTX injection. Results: Exposure of HT 29 and HCT116cells to n-3 PUFA attenuated inhibiting effects of MTX on cell viability. MTX-n-3 PUFA rats demonstrated a lower intestinal injury score and enhanced intestinal repair. A significant decrease in enterocyte apoptosis in MTX+n-3 PUFA rats was accompanied by decreased TNF-α, FAS, FasL, FADD and BID mRNA levels. Decreased NF-κB, COX-2 and TNF-α levels in mucosa was accompanied by a decreased number of IELs and macrophages. Conclusions: n-3 PUFAs inhibit NF-κB/COX-2 induced production of pro-inflammatory cytokines and inhibit cell apoptosis mainly by extrinsic pathway in rats with MTX-induced intestinal damage.

A randomized, double-blind, placebo-controlled study of polyunsaturated fatty acids efficacy in adolescents with anorexia nervosa

2020 ◽  
Vol 36 (2) ◽  
pp. 95-106
Author(s):  
Agnieszka M. Piróg-Balcerzak ◽  
Anna K. Bażyńska ◽  
Katarzyna Biernacka ◽  
Joanna Brągoszewska ◽  
Lidia Popek ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Anorexia Nervosa ◽  
Polyunsaturated Fatty Acids ◽  
Small Sample Size ◽  
Small Sample ◽  
Female Adolescent ◽  
Eating Attitude ◽  
Controlled Study ◽  
Omega 3 ◽  
Eat 26

Objective. Omega–3 polyunsaturated fatty acids (PUFAs) were tested in adolescent depression and in several neurodevelopmental disorders with partial success. Anorexia nervosa (AN) is characterised by deficiencies in fatty food intake and frequent comorbidity, including depressive and cognitive symptoms. Thus supplementation with PUFAs may be beneficial in this group of patients. The aim of the study was to assess whether PUFAs as an add-on treatment is associated with better improvement of body mass index (BMI) and psychopathological symptoms than placebo in patients with AN. Method. 61 female adolescent inpatients with AN were randomly allocated to omega–3 PUFAs supplementation or placebo for 10 weeks. Patients also participated in the behavioural programme and eclectic psychotherapy (treatment as usual, TAU). At baseline and follow-up visits, patients’ BMI and psychopathology were assessed with Clinical Global Impression Scale (CGI), Patient Global Impression Scale (PGI), and Eating Attitude Test (EAT-26). Results. After 10 weeks, both groups showed improvement in all parameters. Improvement in CGI scores was observed greater in placebo vs. PUFA-s group (p = 0.015) while other differences were not statistically significant. Omega–3 PUFAs supplementation appears not to be effective as an add-on treatment in inpatient adolescent girls with anorexia nervosa. Conclusions. The results should be analysed with caution due to small sample size and heterogeneity in TAU. As the TAU turned out to be highly effective, additional therapeutic effect of PUFA might not be visible. Nevertheless, that does not explain the tendency for better improvement in the placebo group.

Omega-3 Polyunsaturated Fatty Acids and Cancer

2013 ◽  
Vol 13 (8) ◽  
pp. 1162-1177 ◽  
Author(s):  
Kaipeng Jing ◽  
Tong Wu ◽  
Kyu Lim
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Omega 3

scholarly journals Dietary soluble flaxseed oils as a source of omega-3 polyunsaturated fatty acids for laying hens

2021 ◽  
pp. 101276
Author(s):  
Sang Hyeok Lee ◽  
Yoo Bhin Kim ◽  
Da-Hye Kim ◽  
Dong-Won Lee ◽  
Hong-Gu Lee ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Laying Hens ◽  
Omega 3
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