scholarly journals Arrestin 1 and Cone Arrestin 4 Have Unique Roles in Visual Function in an All-Cone Mouse Retina

2015 ◽  
Vol 56 (13) ◽  
pp. 7618 ◽  
Author(s):  
Janise D. Deming ◽  
Joseph S. Pak ◽  
Jung-a Shin ◽  
Bruce M. Brown ◽  
Moon K. Kim ◽  
...  
PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e46155 ◽  
Author(s):  
Gerrit Hilgen ◽  
Antje K. Huebner ◽  
Naoyuki Tanimoto ◽  
Vithiyanjali Sothilingam ◽  
Christina Seide ◽  
...  
Keyword(s):  

2015 ◽  
Vol 56 (9) ◽  
pp. 5407 ◽  
Author(s):  
Janise D. Deming ◽  
Joseph S. Pak ◽  
Bruce M. Brown ◽  
Moon K. Kim ◽  
Moe H. Aung ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rui Guo ◽  
Kangkang Ge ◽  
Yuying Wang ◽  
Minxia Lu ◽  
Fei Li ◽  
...  

AbstractLIM homeobox 4 (LHX4) is expressed in the photoreceptors (PRs) of the outer nuclear layer (ONL) and bipolar cells (BCs) of the inner nuclear layer (INL) in mouse and chicken retina. It regulates the subtype-specific development of rod BCs and cone BCs in the mouse retina. However, no report has been published on its expression and function in the zebrafish retina. In this study, we assessed the expression of Lhx4 using in situ hybridization (ISH) technique and explored its role in zebrafish (Danio rerio) retinal development via morpholino (MO) technology. We found that the expression of lhx4 in the zebrafish retina begins 48 h post-fertilization (hpf) and is continuously expressed in the ONL and INL. A zebrafish model constructed with lhx4 knockdown in the eyes through vivo-MO revealed that: lhx4 knockdown inhibits the differentiation of Parvalbumin+ amacrine cells (ACs) and Rhodopsin+ rod photoreceptors (RPs), enhances the expression of visual system homeobox 2 (vsx2); and damages the responses of zebrafish to light stimulus, without affecting the differentiation of OFF-BCs and rod BCs, and apoptosis in the retina. These findings reveal that lhx4 regulates neural differentiation in the retina and visual function during zebrafish embryonic development.


2003 ◽  
Vol 23 (14) ◽  
pp. 6152-6160 ◽  
Author(s):  
Xuemei Zhu ◽  
Bruce Brown ◽  
Aimin Li ◽  
Alan J. Mears ◽  
Anand Swaroop ◽  
...  
Keyword(s):  

2009 ◽  
Vol 106 (35) ◽  
pp. 15043-15048 ◽  
Author(s):  
K. Baba ◽  
N. Pozdeyev ◽  
F. Mazzoni ◽  
S. Contreras-Alcantara ◽  
C. Liu ◽  
...  

2006 ◽  
Vol 47 (9) ◽  
pp. 3745 ◽  
Author(s):  
Shannon E. Haire ◽  
Jijing Pang ◽  
Sanford L. Boye ◽  
Izabel Sokal ◽  
Cheryl M. Craft ◽  
...  

2019 ◽  
Vol 56 (12) ◽  
pp. 8124-8135 ◽  
Author(s):  
Yoko Ozawa ◽  
Eriko Toda ◽  
Hirohiko Kawashima ◽  
Kohei Homma ◽  
Hideto Osada ◽  
...  

2005 ◽  
Vol 47 (11) ◽  
pp. 760 ◽  
Author(s):  
Teresa Randò ◽  
Giovanni Baranello ◽  
Daniela Ricci ◽  
Andrea Guzzetta ◽  
Francesca Tinelli ◽  
...  

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