scholarly journals Light-Driven Cone Arrestin Translocation in Cones of Postnatal Guanylate Cyclase-1 Knockout Mouse Retina Treated with AAV-GC1

2006 ◽  
Vol 47 (9) ◽  
pp. 3745 ◽  
Author(s):  
Shannon E. Haire ◽  
Jijing Pang ◽  
Sanford L. Boye ◽  
Izabel Sokal ◽  
Cheryl M. Craft ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Knockout Mouse ◽  
Mouse Retina ◽  
Cone Arrestin

scholarly journals Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse

PLoS ONE ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. e11306 ◽  
Author(s):  
Shannon E. Boye ◽  
Sanford L. Boye ◽  
Jijing Pang ◽  
Renee Ryals ◽  
Drew Everhart ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Guanylate Cyclase ◽  
Knockout Mouse

scholarly journals GRK1-Dependent Phosphorylation of S and M Opsins and Their Binding to Cone Arrestin during Cone Phototransduction in the Mouse Retina

2003 ◽  
Vol 23 (14) ◽  
pp. 6152-6160 ◽  
Author(s):  
Xuemei Zhu ◽  
Bruce Brown ◽  
Aimin Li ◽  
Alan J. Mears ◽  
Anand Swaroop ◽  
...  
Keyword(s):  
Mouse Retina ◽  
Cone Arrestin

scholarly journals Arrestin 1 and Cone Arrestin 4 Have Unique Roles in Visual Function in an All-Cone Mouse Retina

2015 ◽  
Vol 56 (13) ◽  
pp. 7618 ◽  
Author(s):  
Janise D. Deming ◽  
Joseph S. Pak ◽  
Jung-a Shin ◽  
Bruce M. Brown ◽  
Moon K. Kim ◽  
...  
Keyword(s):  
Visual Function ◽  
Mouse Retina ◽  
Cone Arrestin

scholarly journals MICROGLIA MAY INSTRUCT SYNAPTIC FATE VIA SIRPα IN MOUSE RETINA

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S967-S967
Author(s):  
Danye Jiang ◽  
Melanie Samuel
Keyword(s):  
Knockout Mouse ◽  
Synapse Formation ◽  
Mouse Retina ◽  
Molecular Pathways ◽  
Lacz Reporter ◽  
Age Related ◽  
Neural Information ◽  
Neural Information Processing ◽  
Risk Of Disease ◽  
Sensory Functions

Abstract As we age, our nervous system undergoes many deleterious alterations: cognitive and sensory functions decrease while the risk of disease increases. Synapses are responsible for neural information processing, and the decline of these structures via microglia-mediated remodeling is thought to underline many age-related neural changes. However, the molecular pathways responsible for microglia-mediated synapses removal in development and old age remain unknown. To begin to elucidate these pathways, we leveraged the precisely organized murine retina where neurons form synapses in distinct lamina. Using this system, we screened 102 lacZ reporter lines available through the Knockout Mouse Project (KOMP) and uncovered a unique synapse regulatory candidate, SIRPα. We show that SIRPα is present in microglia prior to synapse formation but becomes selectively enriched in neural synapse terminals as these connections mature. Further, the levels of SIRPα decrease in the context of age-related neural decline. In ongoing studies, we are testing the hypothesis that neuronal SIRPα regulates its receptor CD47 to modulate refinement by microglial SIRPα. Together, these studies will resolve the molecular cues through which microglia prune synapses in development and dissect how these programs may go awry in the context of aging and disease.

scholarly journals Characterization of Ca2+-Binding Protein 5 Knockout Mouse Retina

2008 ◽  
Vol 49 (11) ◽  
pp. 5126 ◽  
Author(s):  
Fred Rieke ◽  
Amy Lee ◽  
Franc¸oise Haeseleer
Keyword(s):  
Knockout Mouse ◽  
Binding Protein ◽  
Mouse Retina

scholarly journals AAV-Mediated Gene Therapy in the Guanylate Cyclase (RetGC1/RetGC2) Double Knockout Mouse Model of Leber Congenital Amaurosis

2013 ◽  
Vol 24 (2) ◽  
pp. 189-202 ◽  
Author(s):  
Sanford L. Boye ◽  
Igor V. Peshenko ◽  
Wei Chieh Huang ◽  
Seok Hong Min ◽  
Issam McDoom ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Guanylate Cyclase ◽  
Knockout Mouse ◽  
Double Knockout ◽  
Knockout Mouse Model ◽  
Leber Congenital Amaurosis ◽  
Double Knockout Mouse

scholarly journals Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 602
Author(s):  
Raju V. S. Rajala ◽  
Austin McCauley ◽  
Rahul Rajala ◽  
Kenneth Teel ◽  
Ammaji Rajala
Keyword(s):  
Growth Factor ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Kinases ◽  
Knockout Mouse ◽  
Tyrosine Phosphatase ◽  
Growth Factor Receptor ◽  
Mouse Retina ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Growth Factor Receptor Bound

Protein tyrosine kinases and protein phosphatases play a critical role in cellular regulation. The length of a cellular response depends on the interplay between activating protein kinases and deactivating protein phosphatases. Protein tyrosine phosphatase 1B (PTP1B) and growth factor receptor-bound protein 14 (Grb14) are negative regulators of receptor tyrosine kinases. However, in the retina, we have previously shown that PTP1B inactivates insulin receptor signaling, whereas phosphorylated Grb14 inhibits PTP1B activity. In silico docking of phosphorylated Grb14 and PTP1B indicate critical residues in PTP1B that may mediate the interaction. Phosphoinositides (PIPs) are acidic lipids and minor constituents in the cell that play an important role in cellular processes. Their levels are regulated by growth factor signaling. Using phosphoinositide binding protein probes, we observed increased levels of PI(3)P, PI(4)P, PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 in PTP1B knockout mouse retina and decreased levels of these PIPs in Grb14 knockout mouse retina. These observations suggest that the interplay between PTP1B and Grb14 can regulate PIP metabolism.

Gene array and knockout mouse analysis of VP-16 induced apoptosis in the murine small intestine

2001 ◽  
Vol 120 (5) ◽  
pp. A660-A660
Author(s):  
D MCMICHAEL ◽  
A DAVIES ◽  
E MARSHMAN ◽  
P OTTEWELL ◽  
J JENKINS ◽  
...  
Keyword(s):  
Small Intestine ◽  
Knockout Mouse ◽  
Gene Array ◽  
Murine Small Intestine ◽  
Induced Apoptosis
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