Foveal Sparing of Reticular Drusen in Eyes With Early and Intermediate Age-Related Macular Degeneration

2015 ◽  
Vol 56 (8) ◽  
pp. 4267 ◽  
Author(s):  
Julia S. Steinberg ◽  
Monika, Fleckenstein ◽  
Frank G. Holz ◽  
Steffen, Schmitz-Valckenberg
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Foveal Sparing ◽  
Reticular Drusen

scholarly journals Outer retinal tubulation formation and clinical course of advanced age-related macular degeneration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alessandro Arrigo ◽  
Emanuela Aragona ◽  
Ottavia Battaglia ◽  
Andrea Saladino ◽  
Alessia Amato ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Müller Cells ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Age Related ◽  
Dry Amd ◽  
Foveal Sparing ◽  
Wet Amd

AbstractOuter retinal tubulations (ORT) are a relatively new finding characterizing outer retinal atrophy. The main aim of the present study was to describe ORT development in advanced age-related macular degeneration (AMD) and to assess its relationship with disease’s severity. Patients with advanced AMD characterized either by macular neovascularization or geographic atrophy, showing signs of outer retinal disruption or retinal pigment epithelium atrophy on structural optical coherence tomography (OCT) at the inclusion examination were prospectively recruited. All the patients underwent complete ophthalmologic evaluation, structural OCT scans and fundus autofluorescence imaging. The planned follow-up was of 3-years. Main outcome measures were ORT prevalence, mechanism of ORT formation, mean time needed for complete ORT formation, best-corrected visual acuity (BCVA), definitely decreased autofluorescence (DDAF) area, questionably decreased autofluorescence (QDAF) area, retinal layer thickness, foveal sparing, number of intravitreal injections. We also assessed the possible role of external limiting membrane (ELM) and Müller cells in ORT pathogenesis. Seventy eyes (70 patients) were included; 43 showed dry AMD evolving to geographic atrophy, while 27 displayed the features of wet AMD. Baseline BCVA was 0.5 ± 0.5 LogMAR, decreasing to 0.9 ± 0.5 LogMAR at the 3-year follow-up (p < 0.01). We detected completely formed ORT in 26/70 eyes (37%), subdivided as follows: 20 eyes (77%) wet AMD and 6 eyes (23%) dry AMD (p < 0.01). ORT took 18 ± 8 months (range 3–35 months) to develop fully. We described the steps leading to ORT development, characterized by progressive involvement of, and damage to the photoreceptors, the ELM and the RPE. Eyes displaying ORT were associated with a smaller QDAF area, less retinal layers damage and lower rate of foveal sparing than eyes free of ORT (p < 0.01). We also described pigment accumulations simulating ORT, which were detected in 16/70 eyes (23%), associated with a greater loss of foveal sparing, increased DDAF area and smaller QDAF area at the 3-year follow-up (p < 0.01). In conclusion, this study provided a description of the steps leading to ORT development in AMD. ELM and Müller cells showed a role in ORT pathogenesis. Furthermore, we described a subtype of pigment hypertrophy mimicking ORT, evaluating its clinical utility.

scholarly journals Scotopic and Photopic Microperimetry in Patients With Reticular Drusen and Age-Related Macular Degeneration

2015 ◽  
Vol 133 (6) ◽  
pp. 690 ◽  
Author(s):  
Julia S. Steinberg ◽  
Fred W. Fitzke ◽  
Rolf Fimmers ◽  
Monika Fleckenstein ◽  
Frank G. Holz ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Reticular Drusen

Reticular Drusen Associated with Geographic Atrophy in Age-Related Macular Degeneration

2011 ◽  
Vol 52 (9) ◽  
pp. 5009 ◽  
Author(s):  
Steffen Schmitz-Valckenberg ◽  
Florian Alten ◽  
Julia S. Steinberg ◽  
Glenn J. Jaffe ◽  
Monika Fleckenstein ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Reticular Drusen

scholarly journals Percentage of Foveal versus Total Macular Geographic Atrophy as a Predictor of Visual Acuity in Age-related Macular Degeneration

2019 ◽  
Author(s):  
Saghar Bagheri ◽  
Ines Lains ◽  
Rebecca Silverman ◽  
Ivana Kim ◽  
Dean Eliott ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Fundus Autofluorescence ◽  
Cross Sectional Study ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Cross Sectional ◽  
Age Related ◽  
The Impact ◽  
Foveal Sparing

AbstractObjectivesTo investigate the relationship between visual acuity (VA), total area of geographic atrophy (GA) and percentage of foveal GA.MethodsMulticenter, retrospective cross-sectional study of patients with GA due to age-related macular degeneration. Demographics, VA, fundus autofluorescence (FAF) and optical coherence tomography (OCT) images were collected. Using FAF images aided by OCT, foveal sparing status, GA pattern, total GA size, and percentage of GA covering the foveal area - area within a 1.5 mm diameter circle centered on the fovea centralis - were assessed. Univariable and multiple linear regression analyses were performed.Results54 eyes (mean age 78.7 ±7.7 (SD), 60.0% female) were studied. Mean VA was 0.8 ± 0.6 logMAR, mean total GA 8.8 ± 6.7 mm2 and mean percentage of foveal GA was 71.5 ± 30.9%. Of all assessed eyes, 48.2% (n = 26) presented with multifocal GA, and 18.5% (n = 10) had foveal sparing. Multiple regression analysis revealed that, controlling for age and GA pattern, the percentage of foveal GA presented a statistically significant association with VA (ß = 0.41, P = 0.004). No significant associations were observed with mean total GA size, while controlling for the same variables (ß = 0.010, P = 0.440).ConclusionPercentage of foveal GA was significantly associated with VA impairment, while the same was not verified for total GA area. These findings suggest that percentage of foveal GA may represent a more useful tool for assessing the impact of GA on VA. Further validation is needed in larger cohorts.

In Vivo Imaging of Foveal Sparing in Geographic Atrophy Secondary to Age-Related Macular Degeneration

2009 ◽  
Vol 50 (8) ◽  
pp. 3915 ◽  
Author(s):  
Steffen Schmitz-Valckenberg ◽  
Monika Fleckenstein ◽  
Hans-Martin Helb ◽  
Peter Charbel Issa ◽  
Hendrik P. N. Scholl ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
In Vivo Imaging ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Foveal Sparing

scholarly journals Foveal-Sparing Scotomas in Advanced Dry Age-Related Macular Degeneration

2008 ◽  
Vol 102 (10) ◽  
pp. 600-610 ◽  
Author(s):  
Janet S. Sunness ◽  
Gary S. Rubin ◽  
Abraham Zuckerbrod ◽  
Carol A. Applegate
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Good Visual Acuity ◽  
Age Related ◽  
Foveal Sparing

Foveal-sparing scotomas are common in advanced dry macular degeneration (geographic atrophy). Foveal preservation may be present for a number of years. Despite good visual acuity, these patients have reduced reading rates. Magnification may not be effective if the text becomes too large to “fit” within the central spared area.

FOVEAL SPARING PHOTOCOAGULATION FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION

Retina ◽  
1994 ◽  
Vol 14 (2) ◽  
pp. 153-159 ◽  
Author(s):  
DAVID H. ORTH ◽  
JOHN P. ROSCULET ◽  
SERGE DE BUSTROS
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Foveal Sparing

Longitudinal Analysis of Reticular Drusen Associated With Geographic Atrophy in Age-Related Macular Degeneration

2013 ◽  
Vol 54 (6) ◽  
pp. 4054 ◽  
Author(s):  
Julia S. Steinberg ◽  
Jasmin Auge ◽  
Glenn J. Jaffe ◽  
Monika Fleckenstein ◽  
Frank G. Holz ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Longitudinal Analysis ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Reticular Drusen

scholarly journals Geographic Atrophy and Foveal-Sparing Changes Related to Visual Acuity in Patients With Dry Age-Related Macular Degeneration Over Time

2017 ◽  
Vol 179 ◽  
pp. 118-128 ◽  
Author(s):  
Ramzi Gilbert Sayegh ◽  
Stefan Sacu ◽  
Roman Dunavölgyi ◽  
Maria Elisabeth Kroh ◽  
Philipp Roberts ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Foveal Sparing ◽  
Over Time

Reticular drusen in eyes with high-risk characteristics for progression to late-stage age-related macular degeneration

2015 ◽  
Vol 99 (9) ◽  
pp. 1289-1294 ◽  
Author(s):  
Julia S Steinberg ◽  
Arno P Göbel ◽  
Monika Fleckenstein ◽  
Frank G Holz ◽  
Steffen Schmitz-Valckenberg
Keyword(s):  
High Risk ◽  
Macular Degeneration ◽  
Late Stage ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Risk Characteristics ◽  
Reticular Drusen
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