scholarly journals Acetylation Preserves Retinal Ganglion Cell Structure and Function in a Chronic Model of Ocular Hypertension

2014 ◽  
Vol 55 (11) ◽  
pp. 7486 ◽  
Author(s):  
Oday Alsarraf ◽  
Jie Fan ◽  
Mohammad Dahrouj ◽  
C. James Chou ◽  
Phillip W. Yates ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Cell Structure ◽  
Structure And Function ◽  
Retinal Ganglion ◽  
Chronic Model ◽  
And Function

XIAP gene therapy effects on retinal ganglion cell structure and function in a mouse model of glaucoma

Gene Therapy ◽  
2021 ◽  
Author(s):  
Shagana Visuvanathan ◽  
Adam N. Baker ◽  
Pamela S. Lagali ◽  
Stuart G. Coupland ◽  
Garfield Miller ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Structure ◽  
Structure And Function ◽  
Retinal Ganglion ◽  
And Function

Development of Retinal Ganglion Cell Structure and Function

2001 ◽  
Vol 20 (2) ◽  
pp. 139-174 ◽  
Author(s):  
Evelyne Sernagor ◽  
Stephen J Eglen ◽  
Rachel O.L Wong
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Structure ◽  
Structure And Function ◽  
Retinal Ganglion ◽  
And Function

Gadd45α affects retinal ganglion cell injury in chronic ocular hypertension rats by regulating p38MAPK pathway

Gene ◽  
2020 ◽  
Vol 763 ◽  
pp. 145030
Author(s):  
Rui-Xue Sun ◽  
Zhao-Hui Sun ◽  
Qian Ren ◽  
Li Li ◽  
Li Yin ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion ◽  
P38mapk Pathway

scholarly journals Rac1 conditional deletion attenuates retinal ganglion cell apoptosis by accelerating autophagic flux in a mouse model of chronic ocular hypertension

2020 ◽  
Vol 11 (9) ◽  
Author(s):  
Meng-Lu Zhang ◽  
Guo-Li Zhao ◽  
Yu Hou ◽  
Shu-Min Zhong ◽  
Lin-Jie Xu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Conditional Knockout ◽  
Autophagic Flux ◽  
Retinal Ganglion ◽  
Conditional Deletion ◽  
New Strategy ◽  
Related Proteins

Abstract Autophagy has a fundamental role in maintaining cell homeostasis. Although autophagy has been implicated in glaucomatous pathology, how it regulates retinal ganglion cell (RGC) injury is largely unknown. In the present work, we found that biphasic autophagy in RGCs occurred in a mouse model of chronic ocular hypertension (COH), accompanied by activation of Rac1, a member of the Rho family. Rac1 conditional knockout (Rac1 cKO) in RGCs attenuated RGC apoptosis, in addition to blocking the increase in the number of autophagosomes and the expression of autophagy-related proteins (Beclin1, LC3-II/I, and p62) in COH retinas. Electron micrograph and double immunostaining of LAMP1 and LC3B showed that Rac1 cKO accelerated autolysosome fusion in RGC axons of COH mice. Inhibiting the first autophagic peak with 3-methyladenine or Atg13 siRNA reduced RGC apoptosis, whereas inhibiting the second autophagic peak with 3-MA or blocking autophagic flux by chloroquine increased RGC apoptosis. Furthermore, Rac1 cKO reduced the number of autophagosomes and apoptotic RGCs induced by rapamycin injected intravitreally, which suggests that Rac1 negatively regulates mTOR activity. Moreover, Rac1 deletion decreased Bak expression and did not interfere with the interaction of Beclin1 and Bcl-2 or Bak in COH retinas. In conclusion, autophagy promotes RGC apoptosis in the early stages of glaucoma and results in autophagic cell death in later stages. Rac1 deletion alleviates RGC damage by regulating the cross talk between autophagy and apoptosis through mTOR/Beclin1-Bak. Interfering with the Rac1/mTOR signaling pathway may provide a new strategy for treating glaucoma.

scholarly journals Mouse model of ocular hypertension with retinal ganglion cell degeneration

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0208713 ◽  
Author(s):  
Ryo Mukai ◽  
Dong Ho Park ◽  
Yoko Okunuki ◽  
Eiichi Hasegawa ◽  
Garrett Klokman ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Cell Degeneration

scholarly journals Independent modes of ganglion cell translocation ensure correct lamination of the zebrafish retina

2016 ◽  
Vol 215 (2) ◽  
pp. 259-275 ◽  
Author(s):  
Jaroslav Icha ◽  
Christiane Kunath ◽  
Mauricio Rocha-Martins ◽  
Caren Norden
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Light Sheet ◽  
Retinal Layer ◽  
Retinal Ganglion ◽  
Layer Formation ◽  
Neuronal Connectivity ◽  
Light Sheet Microscopy ◽  
And Function

The arrangement of neurons into distinct layers is critical for neuronal connectivity and function. During development, most neurons move from their birthplace to the appropriate layer, where they polarize. However, kinetics and modes of many neuronal translocation events still await exploration. In this study, we investigate retinal ganglion cell (RGC) translocation across the embryonic zebrafish retina. After completing their translocation, RGCs establish the most basal retinal layer where they form the optic nerve. Using in toto light sheet microscopy, we show that somal translocation of RGCs is a fast and directed event. It depends on basal process attachment and stabilized microtubules. Interestingly, interference with somal translocation induces a switch to multipolar migration. This multipolar mode is less efficient but still leads to successful RGC layer formation. When both modes are inhibited though, RGCs fail to translocate and induce lamination defects. This indicates that correct RGC translocation is crucial for subsequent retinal lamination.

scholarly journals Form and Function of the M4 Cell, an Intrinsically Photosensitive Retinal Ganglion Cell Type Contributing to Geniculocortical Vision

2012 ◽  
Vol 32 (39) ◽  
pp. 13608-13620 ◽  
Author(s):  
M. E. Estevez ◽  
P. M. Fogerson ◽  
M. C. Ilardi ◽  
B. G. Borghuis ◽  
E. Chan ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Cell Type ◽  
Form And Function ◽  
And Function

scholarly journals JUN is important for ocular hypertension-induced retinal ganglion cell degeneration

2017 ◽  
Vol 8 (7) ◽  
pp. e2945-e2945 ◽  
Author(s):  
Stephanie B Syc-Mazurek ◽  
Kimberly A Fernandes ◽  
Richard T Libby
Keyword(s):  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Cell Degeneration
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