scholarly journals JUN is important for ocular hypertension-induced retinal ganglion cell degeneration

2017 ◽  
Vol 8 (7) ◽  
pp. e2945-e2945 ◽  
Author(s):  
Stephanie B Syc-Mazurek ◽  
Kimberly A Fernandes ◽  
Richard T Libby
Keyword(s):  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Cell Degeneration

scholarly journals Mouse model of ocular hypertension with retinal ganglion cell degeneration

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0208713 ◽  
Author(s):  
Ryo Mukai ◽  
Dong Ho Park ◽  
Yoko Okunuki ◽  
Eiichi Hasegawa ◽  
Garrett Klokman ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Cell Degeneration

Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration

2010 ◽  
Vol 90 (1) ◽  
pp. 168-183 ◽  
Author(s):  
Manuel Salinas-Navarro ◽  
Luis Alarcón-Martínez ◽  
Francisco J. Valiente-Soriano ◽  
Manuel Jiménez-López ◽  
Sergio Mayor-Torroglosa ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Axonal Transport ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Cell Degeneration

scholarly journals Human organotypic retinal cultures (HORCs) as a chronic experimental model for investigation of retinal ganglion cell degeneration

2016 ◽  
Vol 143 ◽  
pp. 28-38 ◽  
Author(s):  
Andrew Osborne ◽  
Marina Hopes ◽  
Phillip Wright ◽  
David C. Broadway ◽  
Julie Sanderson
Keyword(s):  
Ganglion Cell ◽  
Experimental Model ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Cell Degeneration ◽  
Retinal Cultures

scholarly journals Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michal Geva ◽  
Noga Gershoni-Emek ◽  
Luana Naia ◽  
Philip Ly ◽  
Sandra Mota ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Degeneration ◽  
Retinal Ganglion Cells ◽  
Retinal Ganglion Cell ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Cell Degeneration ◽  
Sigma 1 Receptor ◽  
Sigma 1

AbstractOptic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes retinal degeneration. Activation of the S1R exerts neuroprotective effects in models of retinal degeneration. Pridopidine is a highly selective and potent S1R agonist in clinical development. We show that pridopidine exerts neuroprotection of retinal ganglion cells in two different rat models of glaucoma. Pridopidine strongly binds melanin, which is highly expressed in the retina. This feature of pridopidine has implications to its ocular distribution, bioavailability, and effective dose. Mitochondria dysfunction is a key contributor to retinal ganglion cell degeneration. Pridopidine rescues mitochondrial function via activation of the S1R, providing support for the potential mechanism driving its neuroprotective effect in retinal ganglion cells.

Gadd45α affects retinal ganglion cell injury in chronic ocular hypertension rats by regulating p38MAPK pathway

Gene ◽  
2020 ◽  
Vol 763 ◽  
pp. 145030
Author(s):  
Rui-Xue Sun ◽  
Zhao-Hui Sun ◽  
Qian Ren ◽  
Li Li ◽  
Li Yin ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion ◽  
P38mapk Pathway
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