Preservation of the Photoreceptor Layer Following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT

2014 ◽  
Vol 55 (5) ◽  
pp. 3054 ◽  
Author(s):  
Uri Soiberman ◽  
Michaella Goldstein ◽  
Pazit Pianka ◽  
Anat Loewenstein ◽  
Dafna Goldenberg
Keyword(s):  
Macular Edema ◽  
Laser Treatment ◽  
Diabetic Macular Edema ◽  
Photoreceptor Layer ◽  
Subthreshold Laser ◽  
Sd Oct

Photoreceptor Layer Regeneration is Detectable in the Human Retina Imaged by SD-OCT after Laser Treatment Using Subthreshold Laser Power

2012 ◽  
Vol 53 (11) ◽  
pp. 7019 ◽  
Author(s):  
Gábor György Deák ◽  
Matthias Bolz ◽  
Sonja Prager ◽  
Markus Ritter ◽  
Katharina Kriechbaum ◽  
...  
Keyword(s):  
Laser Treatment ◽  
Laser Power ◽  
Human Retina ◽  
Photoreceptor Layer ◽  
Subthreshold Laser ◽  
Sd Oct

scholarly journals Subthreshold lasercoagulation (810 nm) for diabetic macular edema

2018 ◽  
Vol 11 (4) ◽  
pp. 15-20
Author(s):  
Aleksandr S. Izmaylov ◽  
Tat’yana V. Kotsur
Keyword(s):  
Macular Edema ◽  
Laser Treatment ◽  
Diode Laser ◽  
Diabetic Macular Edema ◽  
High Density ◽  
Laser Coagulation ◽  
Retinal Edema ◽  
Grid Pattern ◽  
Significant Difference ◽  
Subthreshold Laser

Introduction. The threshold laser coagulation leads to irreversible damage of retinal structures, microscotomata appearance in the central visual field, contrast sensitivity decrease, and color vision impairment, being accompanied as well by the release of proinflammatory cytokines. For diabetic macular edema treatment, a method of high-density subthreshold laser coagulation (810 nm) was first developed, based on individualized choice of subthreshold parameters of laser irradiation, and permitting confluent application of laser impacts to the retina. Using multimodal diagnostic approach to the estimation of anatomic and functional treatment results, a minimally invasive character and safety of this DME treatment method were confirmed. Purpose. The aim of this study was to comparatively evaluate the efficacy of a diode laser (810 mn) subthreshold laser treatment using high-density laser impact application in diode laser coagulation (DLC) and diode microphotocoagulation (DMP) modes. Materials and methods. To compare the efficacy of subthreshold laser treatment methods (DLC and DMP), patients were divided into two groups, comparable in macular edema thickness and area. The first group (24 eyes) received a macular laser coagulation in grid pattern and MicroPulse diode laser (810 nm) regimen; biomicroscopically it was predominantly subthreshold high-density application of burns. The second group (29 eyes) received a macular laser coagulation in grid pattern and continuous diode laser (810 nm) regimen; biomicroscopically it was predominantly subthreshold high-density application of burns. Results. After DLC and DMP, there was no statistically significant difference between compared groups in best corrected visual acuity. There was also no significant difference in retinal edema maximal height dynamics, retinal edema area, and central thickness in 2 and 4 months. Conclusion. Subthreshold microphotocoagulation and laser coagulation methods at the same average power of laser exposure and other exposure parameters in the shortterm follow-up have comparable efficacy in the treatment of diabetic macular edema.

scholarly journals Comparison of different settings for yellow subthreshold laser treatment in diabetic macular edema

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Jay Chhablani ◽  
Rayan Alshareef ◽  
David Ta Kim ◽  
Raja Narayanan ◽  
Abhilash Goud ◽  
...  
Keyword(s):  
Macular Edema ◽  
Laser Treatment ◽  
Diabetic Macular Edema ◽  
Subthreshold Laser

Clinical efficacy of subthreshold laser treatment for focal diabetic macular edema using a navigation system (short-term results)

2021 ◽  
pp. 217-221
Author(s):  
P.L. Volodin ◽  
◽  
E.V. Ivanova ◽  
E. I. Polyakova ◽  
◽  
...  
Keyword(s):  
Macular Edema ◽  
Laser Treatment ◽  
Diabetic Macular Edema ◽  
Clinical Efficacy ◽  
Morphological Changes ◽  
Foveal Avascular Zone ◽  
Laser Exposure ◽  
Retinal Sensitivity ◽  
Subthreshold Laser

Purpose. To evaluate the clinical efficacy of subthreshold laser treatment for focal DME with continuous and micropulse mode based on navigated technology. Methods. We observed 17 patients (17 eyes) with DME at the age from 25 to 71 years (on average 44±1.6 years). After the stage of diagnostic search for morphological changes in the retina and preoperative planning all patients underwent navigational laser treatment in and continuous and micropulse mode. The study evaluated the retinal thickness in the foveal avascular zone and outside it, the area of retinal ischemia, microaneurysms and edema zones at the level of the superficial vascular plexus and deep vascular complex. Follow-up periods were 1 and 3 months. Results. One month after laser treatment, all patients had positive dynamics, expressed in a decrease of edema height. BCVA increased on average to 0.8±0.06; mean central retinal sensitivity – up to 24.65±0.47 dB. After 3 months, a further decrease in the height of the edema was observed. BCVA increased on average for the group to 0.85±0.06, mean central retinal sensitivity – 25.5±0.3 dB. Сonclusion. Our preliminary results indicate the effectiveness of navigational subthreshold laser treatment for DME, based on targeted topographically oriented laser exposure according to OCT-angiography. Keywords: diabetic macular edema, navigational laser treatment, subthreshold laser therapy.

Comparative efficacy of micropulse laser treatment of diabetic macular edema

2019 ◽  
pp. 24-27
Author(s):  
M.Y. Guro ◽  
◽  
Y.Y. Khzardzhan ◽  
V.N. Potapova ◽  
A.S. Balalin ◽  
...  
Keyword(s):  
Macular Edema ◽  
Laser Treatment ◽  
Diabetic Macular Edema ◽  
Comparative Efficacy ◽  
Micropulse Laser

scholarly journals Subthreshold Micropulse Laser Modulates Retinal Neuroinflammatory Biomarkers in Diabetic Macular Edema

2021 ◽  
Vol 10 (14) ◽  
pp. 3134
Author(s):  
Luisa Frizziero ◽  
Andrea Calciati ◽  
Giulia Midena ◽  
Tommaso Torresin ◽  
Raffaele Parrozzani ◽  
...  
Keyword(s):  
Macular Edema ◽  
Laser Treatment ◽  
Diabetic Macular Edema ◽  
Metabolic Pathways ◽  
Treatment Method ◽  
Micropulse Laser ◽  
Subthreshold Micropulse Laser ◽  
Inflammatory Processes ◽  
Standardized Parameters

Subthreshold micropulse laser treatment has become a recognized option in the therapeutic approach to diabetic macular edema. However, some yet undefined elements pertaining to its mechanism of action and most effective treatment method still limit its clinical diffusion. We reviewed the current literature on subthreshold micropulse laser treatment, particularly focusing on its effects on the modulation of retinal neuroinflammation. Subthreshold micropulse laser treatment seems to determine a long-term normalization of specific retinal neuroinflammatory metabolic pathways, contributing to the restoration of retinal homeostasis and the curtailing of local inflammatory processes. Optimized and standardized parameters ensure effective and safe treatment.

scholarly journals External limiting membrane: retinal structural barrier in diabetic macular edema

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sandeep Saxena ◽  
Levent Akduman ◽  
Carsten H. Meyer
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Barrier Effect ◽  
External Limiting Membrane ◽  
Ellipsoid Zone ◽  
Structural Barrier ◽  
Sd Oct

AbstractAdvances in spectral-domain optical coherence tomography (SD-OCT) technology have enhanced the understanding of external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema. An increase in VEGF has been demonstrated to be associated with sequential ELM and EZ disruption on SD-OCT. An intact ELM is a prerequisite for an intact EZ in DME. Anti-VEGF therapy leads to restoration of barrier effect of ELM. The ELM restores first followed by EZ restoration.

scholarly journals Repeatability of Bruch’s Membrane Opening-minimum Rim Width in Age-related Macular Degeneration and Diabetic Macular Edema

2021 ◽  
Vol 62 (11) ◽  
pp. 1490-1501
Author(s):  
Bum Jun Kim ◽  
Woo Hyuk Lee ◽  
Ki Yup Nam ◽  
Ji Hye Kim ◽  
Tae Seen Kang ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Macular Edema ◽  
Optic Disc ◽  
Diabetic Macular Edema ◽  
Age Related Macular Degeneration ◽  
Disc Membrane ◽  
Rnfl Thickness ◽  
Age Related ◽  
Bruch’S Membrane Opening ◽  
Sd Oct

Purpose: To evaluate the repeatability of retinal nerve fiber layer (RNFL) thickness and Bruch’s membrane opening-minimum rim width (BMO-MRW) measurements by spectral-domain optical coherence tomography (SD-OCT) in wet age-related macular degeneration (wAMD) and diabetic macular edema (DME).Methods: This was a prospective study. The RNFL thickness and BMO-MRW parameters for each sector and global average were measured twice by SD-OCT. Repeatability was evaluated using the intraclass correlation coefficient (ICC) and coefficient of variation (CV). If the optic disc membrane was confirmed, it was analyzed by dividing it into three groups based on severity.Results: A total of 99 eyes (48 with wAMD, 51 with DME) were included in the analysis. The ICCs of the global RNFL thickness and global BMO-MRW measurements were 0.996 and 0.997, respectively, in wAMD and 0.994 and 0.996, respectively, in DME eyes. The CV values of global RNFL thickness and BMO-MRW were 0.60% and 0.73%, respectively, in wAMD eyes and 1.10% and 1.21%, respectively, in DME eyes. The disc membrane on the optic nerve head significantly affected global BMO-MRW repeatability (B = 0.814, p < 0.001).Conclusions: Both RNFL thickness and BMO-MRW measurements showed good repeatability in eyes with wAMD and DME. The severity of the optic disc membrane significantly affected the repeatability of BMO-MRW measurements in eyes with wAMD and DME. Therefore, physicians should examine the BMO-MRW in eyes with severe optic disc membrane.

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